3(S)-Hydroxymethyl-4-benzylmorpholine
- CAS No.
- 101376-25-4
- Chemical Name:
- 3(S)-Hydroxymethyl-4-benzylmorpholine
- Synonyms
- (S)-(4-benzylMorpholin-3-yl)Methanol;(3S)-4-benzylmorpholin-3-yl]methanol;(S)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE;(S)-4-(phenylmethyl)-3-Morpholinemethanol;(3S)-4-(Phenylmethyl)-3-morpholinemethanol;3-Morpholinemethanol, 4-(phenylmethyl)-, (3S)-;(3S)-4-(Phenylmethyl)-3-morpholinemethanol,99%e.e.;(4-Benzyl-3-Morpholinyl)Methanol (4Benzylmorpholin3yl)methanol
- CBNumber:
- CB31010241
- Molecular Formula:
- C12H17NO2
- Molecular Weight:
- 207.27
- MDL Number:
- MFCD06799482
- MOL File:
- 101376-25-4.mol
- MSDS File:
- SDS
| Melting point | 230-231 °C(Solv: ethanol (64-17-5); ethyl ether (60-29-7)) |
|---|---|
| Boiling point | 322.7±22.0 °C(Predicted) |
| Density | 1.117±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 14.85±0.10(Predicted) |
| color | Pale Yellow to Pale Beige |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| HS Code | 2934999090 |
3(S)-Hydroxymethyl-4-benzylmorpholine price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 160933 | (3S)-4-(Phenylmethyl)-3-morpholinemethanol | 101376-25-4 | 100mg | $531 | 2026-06-03 | Buy |
| AstaTech | 53729 | (S)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE 97% | 101376-25-4 | 0.25G | $49 | 2026-04-30 | Buy |
| AstaTech | 53729 | (S)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE 97% | 101376-25-4 | 1G | $103 | 2026-04-30 | Buy |
| Apolloscientific | OR451055 | (S)-(4-Benzylmorpholin-3-yl)methanol 97% | 101376-25-4 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR451055 | (S)-(4-Benzylmorpholin-3-yl)methanol 97% | 101376-25-4 | 250mg | $29 | 2026-06-04 | Buy |
3(S)-Hydroxymethyl-4-benzylmorpholine Chemical Properties, Uses, Production
Uses
(s)-(4-Benzylmorpholin-3-yl)methanol is used in the synthesis of a non-stimulant appetite suppressant. Different from conventional food suppressants as it does not release neurotransmitters.
Uses
(3S)-4-(Phenylmethyl)-3-morpholinemethanol is used in the synthesis of a non-stimulant appetite suppressant. Different from conventional food suppressants as it does not release neurotransmitters.
Synthesis
106973-36-8
101376-25-4
General procedure for the synthesis of (S)-(4-benzylmorpholin-3-yl)methanol from (R)-4-benzyl-5-oxo-3-morpholinecarboxylic acid: to a stirred solution of (R)-4-benzyl-5-oxo-3-morpholinecarboxylic acid (17.7 g, 75.3 mmol) in tetrahydrofuran (THF, 300 mL) was added triethylamine (NEt3, 7.3 g, 10.0 mL, 72.0 mmol). The reaction mixture was cooled to 0 °C and dimethyl sulfide borane complex (BH3-Me2S, 10 M THF solution, 45.0 mL, 450.0 mmol) was slowly added. After heating and refluxing the reaction mixture for 12 h, it was cooled to room temperature and the excess borane was quenched by slow addition of methanol (MeOH) at 0 °C. The reaction mixture was concentrated in vacuum and the resulting white solid was dissolved in ethyl acetate (EtOAc, 120 mL) and washed with aqueous sodium hydroxide (20% v/v, 2 x 100 mL). The organic phase was extracted with 2M aqueous hydrochloric acid (2 x 150mL). The acidic aqueous phases were combined, alkalized to pH 14 with solid sodium hydroxide, and back-extracted with ethyl acetate (2 × 150 mL). The organic phases were combined, washed with brine (150 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated in vacuum to give (S)-(4-benzylmorpholin-3-yl)methanol (13.5 g, 87% yield) as a clear oil, which did not need to be further purified. δH(CDCl3) 7.29-7.16 (5H, m), 4.05 (1H, d, J = 12.8 Hz), 3.88 (1H, dd, J=11.5 Hz and J=4.5 Hz), 3.78 (1H, m), 3.70-3.53 (2H, m), 3.51-3.40 (2H, m), 3.20 (1H, d, J=13.2 Hz), 2.68 (1H, dt, J=12.1 Hz and J=2.8 Hz). 2.48 (1H, m), 2.27 (1H, m), 2.20-2.15 (1H, br.s).
References
[1] Patent: WO2008/47109, 2008, A1. Location in patent: Page/Page column 40-41
[2] Patent: WO2009/1089, 2008, A1. Location in patent: Page/Page column 29
[3] Patent: WO2009/71895, 2009, A1. Location in patent: Page/Page column 110
[4] Patent: US2011/3785, 2011, A1. Location in patent: Page/Page column 11
[5] Patent: US2008/255114, 2008, A1. Location in patent: Page/Page column 31
3(S)-Hydroxymethyl-4-benzylmorpholine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Daicel Chiral Technologies (China)CO.,LTD | 021-50460086-9 15921403865 | han_yajun@dctc.daicel.com | China | 7909 | 65 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Acesys Pharmatech | 18860950986 | tangmanman@zenjipharma.com | China | 1731 | 55 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Xunteng International Trading Co.,Limited | China Hong Kong | 876 | 55 | ||
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
View Latest Price from 3(S)-Hydroxymethyl-4-benzylmorpholine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2020-01-10 | 3(S)-HYDROXYMETHYL-4-BENZYLMORPHOLINE
101376-25-4
|
$1.00 | 1KG | 99% | 100KG | Career Henan Chemical Co |
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- 3(S)-HYDROXYMETHYL-4-BENZYLMORPHOLINE
101376-25-4
- $1.00
- 99%
- Career Henan Chemical Co
