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3(S)-Hydroxymethylmorpholine

3(S)-Hydroxymethylmorpholine Structure
3(S)-Hydroxymethylmorpholine structure
CAS No.
211053-50-8
Chemical Name:
3(S)-Hydroxymethylmorpholine
Synonyms
(S)-morpholin-3-ylmethanol;(3S)-3-Morpholinemethanol;(3S)-morpholin-3-ylmethanol;3-Morpholinemethanol, (3S)-;3(S)-Hydroxymethylmorpholine;(S)-3-Hydroxymethylmorpholine;(3S)-3-(Hydroxymethyl)morpholine;(3S)-3-Morpholinemethanol,99%e.e.;(3S)-3-(Hydroxymethyl)morpholine,hydrochloride(1：1)
CBNumber:
CB9266263
Molecular Formula:
C5H11NO2
Molecular Weight:
117.15
MDL Number:
MFCD06799480
MOL File:
211053-50-8.mol
MSDS File:
SDS
Last updated:2026-09-12 18:56:20
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3(S)-Hydroxymethylmorpholine Properties

Melting point 112 °C
Boiling point 218.3±20.0 °C(Predicted)
Density 1.045±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 14.85±0.10(Predicted)
Appearance Off-white to brown Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H319-H302-H315-H335
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
RIDADR  3261
HazardClass  8
PackingGroup  Ⅲ

3(S)-Hydroxymethylmorpholine price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Biosynth FM154328 (S)-Morpholin-3-ylmethanol 211053-50-8 100mg $150 2026-06-04 Buy
Biosynth FM154328 (S)-Morpholin-3-ylmethanol 211053-50-8 250mg $157.5 2026-06-04 Buy
Biosynth FM154328 (S)-Morpholin-3-ylmethanol 211053-50-8 500mg $270 2026-06-04 Buy
Matrix Scientific 308556 (S)-Morpholin-3-ylmethanol 211053-50-8 250.00mg $69 2026-05-19 Buy
Matrix Scientific 308556 (S)-Morpholin-3-ylmethanol 211053-50-8 1.00g $86 2026-05-19 Buy
Product number Packaging Price Buy
FM154328 100mg $150 Buy
FM154328 250mg $157.5 Buy
FM154328 500mg $270 Buy
308556 250.00mg $69 Buy
308556 1.00g $86 Buy

3(S)-Hydroxymethylmorpholine Chemical Properties,Uses,Production

Uses

(S)-3-Hydroxymethylmorpholine is a chemical reagent used in the synthesis of Aurora kinase inhibitors, used for their anti-tumor activity. Also used in the preparation of human epidermal growth factor receptor 1 & 2 kinase inhbitors in the treatment of solid tumors.

Synthesis

3(S)-HYDROXYMETHYL-4-BENZYLMORPHOLINE

101376-25-4

3(S)-HYDROXYMETHYLMORPHOLINE

211053-50-8

To a solution of (S)-(4-benzylmorpholin-3-yl)methanol (10.0 g, 48.3 mmol) in methanol (300 mL) was added 10 wt% of carbon-loaded palladium catalyst (2.0 g), and the reaction mixture was transferred to a Parr reactor. The reaction was carried out for 18 hours at room temperature under hydrogen pressure of 50 psi. Upon completion of the reaction, the mixture was filtered through a Celite pad to remove the catalyst. The filtrate was concentrated under reduced pressure to afford (S)-3-hydroxymethylmorpholine (5.2 g, 92% yield) as a colorless oil.1H NMR (CDCl3) δ: 3.81-3.76 (2H, m), 3.58-3.43 (3H, m), 3.35-3.28 (1H, m), 2.99-2.91 (5H, br.m). Mass spectrum (ES+) m/z: 118.0 ([M + H]+).

References

[1] Patent: WO2008/47109, 2008, A1. Location in patent: Page/Page column 41
[2] Patent: WO2009/1089, 2008, A1. Location in patent: Page/Page column 29-30
[3] Patent: WO2009/71895, 2009, A1. Location in patent: Page/Page column 110
[4] Patent: US2011/3785, 2011, A1. Location in patent: Page/Page column 11
[5] Patent: WO2006/114606, 2006, A1. Location in patent: Page/Page column 78

3(S)-Hydroxymethylmorpholine synthesis

106973-36-8
211053-50-8
Synthesis of 3(S)-Hydroxymethylmorpholine from (R)-4-Benzyl-5-oxo-3-morpholinecarboxylic Acid

3(S)-Hydroxymethylmorpholine Preparation Products And Raw materials

Raw materials

Morpholine, 3-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-, (3R)- (R)-4-Benzyl-5-oxo-3-morpholinecarboxylic Acid 3(S)-Hydroxymethyl-4-benzylmorpholine Methanol Hydrogen

Preparation Products

3(S)-Hydroxymethylmorpholine Suppliers

Global( 89)Suppliers
Supplier Tel Email Country ProdList Advantage
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
ForeChem (Nantong) Technology Co.,Ltd. 513-85982855 18921614129 sales@xianxingpharm.com China 2712 61
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Shanghai Ennopharm Co., Ltd. +86 (21) 6435-5022 China 4263 65
Hangzhou Sage Chemical Co., Ltd. +86057186818502 13588463833 info@sagechem.com China 10265 58
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Shanghai Sheepchem Co., Ltd. +86 (21) 6715-7650 sheepchem@163.com China 993 60
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Chengdu Firster Pharmaceutical Co., Ltd. 028-87078428 028-87074958 chengzhenyong@cdfirster.com China 2580 60
Supplier Advantage
PharmaBlock Sciences (Nanjing),Inc. 55
ForeChem (Nantong) Technology Co.,Ltd. 61
Capot Chemical Co., Ltd 66
Shanghai Ennopharm Co., Ltd. 65
Hangzhou Sage Chemical Co., Ltd. 58
9ding chemical ( Shanghai) Limited 56
Shanghai Sheepchem Co., Ltd. 60
Shanghai Raise Chemical Technology Co.,Ltd 55
Bide Pharmatech Ltd. 60
Chengdu Firster Pharmaceutical Co., Ltd. 60

View Lastest Price from 3(S)-Hydroxymethylmorpholine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3(S)-HYDROXYMETHYLMORPHOLINE pictures 2019-12-20 3(S)-HYDROXYMETHYLMORPHOLINE
211053-50-8
 $1.00 1KG 97-99% 1000KGS Career Henan Chemical Co

3(S)-Hydroxymethylmorpholine Spectrum

3(S)-HYDROXYMETHYLMORPHOLINE(211053-50-8)1HNMR

211053-50-8(3(S)-Hydroxymethylmorpholine)Related Search:

4-Boc-3(R)-morpholinecarboxylic acid (R)-3-MORPHOLINECARBOXYLIC ACID HCL (S)-N-BOC-2-HYDROXYMETHYLMORPHOLINE,(S)-2-Hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester 2-HYDROXYMETHYLMORPHOLINE,2-HYDROXYMETHYLMORPHOLINE 95% (R)-N-Boc-2-Hydroxymethylmorpholine
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4-FMOC-3(R)-MORPHOLINECARBOXYLIC ACID (S)-N-BENZYL-2-HYDROXYMETHYLMORPHOLINE (R)-4-BENZYL-3-HYDROXYMETHYLMORPHOLINE 3-Hydroxymethyl-morpholine-4-carboxylic acid tert-butyl ester 3(S)-Hydroxymethylmorpholine
4-Benzyl-3-hydroxymethylmorpholine 3(S)-Hydroxymethyl-4-benzylmorpholine 4-Cbz-2-hydroxymethylmorpholine

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(3S)-3-Morpholinemethanol (3S)-3-Morpholinemethanol,99%e.e. (S)-3-Hydroxymethylmorpholine 3-Morpholinemethanol, (3S)- (3S)-morpholin-3-ylmethanol (3S)-3-(Hydroxymethyl)morpholine (3S)-3-(Hydroxymethyl)morpholine,hydrochloride(1：1) (S)-morpholin-3-ylmethanol 3(S)-Hydroxymethylmorpholine 211053-50-8 pharmacetical