4-Benzyl-3-hydroxymethylmorpholine
- CAS No.
- 110167-20-9
- Chemical Name:
- 4-Benzyl-3-hydroxymethylmorpholine
- Synonyms
- (4-Benzylmorpholin-3-yl);4-Benzyl-3-MorpholineMethanol;4-Bn-3-hydroxymethylmorpholine;4-Benzyl-3-hydroxymethylmorpholine;N-Benzyl-3-(hydroxymethyl)morpholine;3-Morpholinemethanol, 4-(phenylmethyl)-
- CBNumber:
- CB3846128
- Molecular Formula:
- C12H17NO2
- Molecular Weight:
- 207.27
- MDL Number:
- MFCD04038651
- MOL File:
- 110167-20-9.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319-H315-H335 |
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501 |
4-Benzyl-3-hydroxymethylmorpholine price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 53728 | 4-BENZYL-3-HYDROXYMETHYLMORPHOLINE 97% | 110167-20-9 | 0.25G | $46 | 2026-04-30 | Buy |
| AstaTech | 53728 | 4-BENZYL-3-HYDROXYMETHYLMORPHOLINE 97% | 110167-20-9 | 1G | $68 | 2026-04-30 | Buy |
| AstaTech | 53728 | 4-BENZYL-3-HYDROXYMETHYLMORPHOLINE 97% | 110167-20-9 | 5G | $365 | 2026-04-30 | Buy |
| Activate Scientific | AS21814 | N-Benzyl-3-(hydroxymethyl)morpholine 97% | 110167-20-9 | 1g | $54 | 2026-06-04 | Buy |
| Activate Scientific | AS21814 | N-Benzyl-3-(hydroxymethyl)morpholine 97% | 110167-20-9 | 5g | $183 | 2026-06-04 | Buy |
4-Benzyl-3-hydroxymethylmorpholine Chemical Properties, Uses, Production
Synthesis
106910-79-6
110167-20-9
General procedure for the synthesis of N-benzyl-3-hydroxymethylmorpholine from 4-benzyl-5-oxo-3-morpholinecarboxylic acid: triethylamine (7.29 g, 10.0 mL, 72 mmol) was added to a solution of intermediate 58 (17.7 g, 75.3 mmol) in tetrahydrofuran (THF, 300 mL). The reaction system was cooled to 0 °C and the borane dimethyl sulfide complex (~10 M solution of THF, 45 mL, 450 mmol) was slowly added. Subsequently, the reaction mixture was heated to reflux for 16 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the excess borane was carefully destroyed. The excess THF was evaporated under reduced pressure and the residue was adjusted to strong basicity with 2 M NaOH solution (250 mL) and subsequently extracted with ethyl acetate (EtOAc, 3 x 150 mL). The aqueous phase was acidified to pH 1 with concentrated hydrochloric acid and extracted again. The combined organic phases were washed with brine (150 mL), dried over anhydrous magnesium sulfate (MgSO4), and concentrated under reduced pressure to give N-benzyl-3-hydroxymethylmorpholine (13.5 g, 87% yield) as a clear oil.1H NMR (CDCl3) δ: 7.29-7.16 (5H, m), 4.05 (1H, d, J = 12.8 Hz), 3.88 (1H dd, J = 11.5, 4.5 Hz), 3.78 (1H, m), 3.70-3.53 (2H, m), 3.51-3.40 (2H, m), 3.20 (1H, d, J = 13.2 Hz), 2.68 (1H, dt, J = 12.1, 2.8 Hz), 2.48 (1H, m), 2.27 (1H, m). 2.20-2.15 (1H, bs).
References
[1] Patent: WO2006/114606, 2006, A1. Location in patent: Page/Page column 58-59
[2] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1985, p. 2577 - 2580
4-Benzyl-3-hydroxymethylmorpholine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Raise Chemical Technology Co.,Ltd | +86-021-50935922 | China | 7854 | 55 | |
| Amatek Scientific Co. Ltd. | 0512-56316828 4008675858 | sales@amateksci.com | China | 9848 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Chengdu Firster Pharmaceutical Co., Ltd. | 028-87078428 028-87074958 | chengzhenyong@cdfirster.com | China | 2580 | 60 |
| Shanghai Balmxy Pharmaceutical Co., Ltd | 021-24206007 13764915196 | sales@balmxy.com | China | 6959 | 55 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 86-574-27787657 | info@dearchem.com | China | 4607 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Accela ChemBio Inc. | +1(858) 699-3322 | marketing@accelachem.com | United States | 6022 | 65 |
View Latest Price from 4-Benzyl-3-hydroxymethylmorpholine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 4-BENZYL-3-HYDROXYMETHYLMORPHOLINE
110167-20-9
|
500g | 98%; 99% | 500g；1kg； 10kg; 25kg | Career Henan Chemical Co |
-
- 4-BENZYL-3-HYDROXYMETHYLMORPHOLINE
110167-20-9
- $0.01
- 98%; 99%
- Career Henan Chemical Co
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