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1,4-BIS(2-HYDROXYETHYL)PIPERAZINE

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE structure

CAS No.: 122-96-3

Chemical Name:: 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE

Synonyms: 2-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]ETHANOL;AKOS BB-4936;1,4-BIS(2-HYDROXYETH;1,4-PIPERAZINEDIETHANOL;N,N'-PIPERAZINDIETHANOL;N,N'-PIPERAZINEDIETHANOL;piperazine-1,4-diethanol;Piperazine-1,4-bisethanol;DI(HYDROXYETHYL)PIPERAZINE;N,N'-Dihydroxyethylpiperazine

CBNumber:: CB3115114

Molecular Formula:: C8H18N2O2

Molecular Weight:: 174.24

MDL Number:: MFCD00006157

MOL File:: 122-96-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:56:05

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1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Properties

Melting point	133.5-136 °C(lit.)
Boiling point	215-220 °C50 mm Hg(lit.)
Density	1.097
vapor pressure	0.004Pa at 20℃
refractive index	1.4540 (estimate)
Flash point	166℃
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	powder to crystal
pka	14.66±0.10(Predicted)
color	White to Almost white
Water Solubility	Soluble in water.
InChI	1S/C8H18N2O2/c11-7-5-9-1-2-10(4-3-9)6-8-12/h11-12H,1-8H2
InChIKey	VARKIGWTYBUWNT-UHFFFAOYSA-N
SMILES	OCCN1CCN(CCO)CC1
LogP	-1.92 at 20℃
CAS DataBase Reference	122-96-3(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	EQ349PKX8Y
EPA Substance Registry System	1,4-Piperazinediethanol (122-96-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

37/39-26

WGK Germany

RTECS

TL3675000

TSCA

TSCA listed

HS Code

2933.59.9500

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Dam. 1

REACH Registrations

Active

NFPA 704

	1
2		0

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE price More Price(51)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B45402	1,4-Bis(2-hydroxyethyl)piperazine 99%	122-96-3	5g	$66.3	2026-04-30	Buy
Sigma-Aldrich	B45402	1,4-Bis(2-hydroxyethyl)piperazine 99%	122-96-3	25g	$201	2026-04-30	Buy
TCI Chemical	B4903	1,4-Bis(2-hydroxyethyl)piperazine >98.0%(GC)(T)	122-96-3	5g	$32	2026-04-30	Buy
TCI Chemical	B4903	1,4-Bis(2-hydroxyethyl)piperazine >98.0%(GC)(T)	122-96-3	25g	$110	2026-04-30	Buy
Usbiological	263838	1,4-Bis(2-hydroxyethyl)piperazine Asreported	122-96-3	5g	$382	2026-06-03	Buy

Product number	Packaging	Price	Buy
B45402	5g	$66.3	Buy
B45402	25g	$201	Buy
B4903	5g	$32	Buy
B4903	25g	$110	Buy
263838	5g	$382	Buy

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

1,4-Piperazinediethanol is useful in the synthesis of salt-inducible kinase inhibitors for the treatment of diseases.

Flammability and Explosibility

Not classified

Synthesis

111-42-2

122-96-3

The general procedure for the synthesis of N,N'-bis(2-hydroxyethyl)piperazine from diethanolamine is as follows: Example 2: Preparation of 1,4-bis(hydroxyethyl)piperazine from diethanolamine under solvent-free conditions Operational steps: 1. 100 g of diethanolamine (II) and 10 g of Catalyst A were added in the same reaction setup described in Example 1 . 2. Upon completion of the reaction, the reaction product was detected by gas chromatography analysis (GC column: 30m RTX Amin). 3. The analytical results showed that the content of 1,4-bis(hydroxyethyl)piperazine in the reaction product was 79% under the condition of complete conversion of diethanolamine.

References

[1] Patent: US2012/108816, 2012, A1. Location in patent: Page/Page column 6
[2] Patent: US2868791, 1954,
[3] Patent: US2636033, 1950,
[4] Patent: DE917784, 1952,

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE synthesis

Synthesis of 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE from Diethanolamine

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Ethanol Sodium sulfate Potassium carbonate Piperazine 2-Chloroethanol

Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide 3-(2-HYDROXYETHYL)-2-OXAZOLIDINONE

ETHYLENE OXIDE 2-Bromoethanol Carbon dioxide

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Preparation Products

1-(2-Hydroxyethyl)piperazine

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Suppliers

Global( 241)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Beijing Isomersyn Technology CO;LTD	010-82954736 13391601435	sales@isomersyn.com	China	3294	57
Syntechem Co.,Ltd		info@syntechem.com	China	12973	57
Tangshan Moneide Trading Co., Ltd.	0315-8309571 15633399667	sales@moneidechem.com	China	703	57

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
Beijing Ouhe Technology Co., Ltd	60
Pure Chemistry Scientific Inc.	62
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Beijing Isomersyn Technology CO;LTD	57
Syntechem Co.,Ltd	57
Tangshan Moneide Trading Co., Ltd.	57

View Lastest Price from 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 122-96-3	$1.10	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2021-07-02	1,4-Bis(2-hydroxyethyl)piperazine 122-96-3	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 122-96-3	$1.00	1KG	99%		Career Henan Chemical Co

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
122-96-3
$1.10
99.9%
Dideu Industries Group Limited

1,4-Bis(2-hydroxyethyl)piperazine
122-96-3
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
122-96-3
$1.00
99%
Career Henan Chemical Co

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Spectrum

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)MS 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)¹HNMR 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)¹³CNMR 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)IR1 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)IR2 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)Raman

122-96-3(1,4-BIS(2-HYDROXYETHYL)PIPERAZINE)Related Search:

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6(1H)-Purinone, 2,3-dihydro-3,7-dimethyl-1-(2-hydroxy-3-(4-(2-hydroxye thyl)piperazinyl)propyl)- 1,4-BIS(2-HYDROXYPROPYL)-2-METHYLPIPERAZINE 2-PHENOXY-1-[4-(2-PHENOXY-ACETYL)-PIPERAZIN-1-YL]-ETHANONE

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DI(HYDROXYETHYL)PIPERAZINE AKOS BB-4936 1,4'-BIS(2-HYDROXYETHYL)PIPERAZINE 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 1,4-PIPERAZINEDIETHANOL 1,4-Bis(beta-hydroxyethyl)piperazine 1,4-Di(2-hydroxyethyl)piperazine n,n’-bis(2-hydroxyethyl)-piperazin n,n’-bis(beta-hydroxyethyl)piperazine n,n’-di(2-hydroxyethyl)piperazine N,N'-Bis(beta-hydroxyethyl)piperazine N,N'-Di(2-hydroxyethyl)piperazine N,N'-Dihydroxyethylpiperazine Piperazine, N,N'-bis(2-hydroxyethyl)- N,N'-PIPERAZINDIETHANOL N,N'-PIPERAZINEDIETHANOL piperazine,N,N’-bis(2-hydroxyethyl)- piperazine-1,4-diethanol 1,4-Piperazinediethanol(6CI,7CI,8CI,9CI) 2,2''-PIPERAZINE-1,4-DIYLDIETHANOL 2,2'-(1,4-Piperazinediyl)diethanol Piperazine-1,4-bisethanol N,N'-Bis(2-hydroxyethyl)piperazine,99% 1,4-Bis(2-hydroxyethyl)piperazine,1,4-Piperazinediethanol 1,4-BIS(2-HYDROXYETH 1,4-Bis(2-hydroxyethyl)piperazine 1,4-Bis(2-hydroxyethyl)piperazine 99% 1,4-Bis(2-hydroxyethyl)piperazine > 1,4-Bis(2-hydroxyethyl)piperazine,98% 4-BIS(2-HYDROXYETHYL)PIPERAZINE TIANFU CHEM 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 1,4-Piperazinediethanol (6CI, 7CI, 8CI, 9CI, ACI) n,n'-bis(2-hydroxyethyl)piperazine 2,2'-(Piperazine-1,4-diyl)diethanol N,N'-Bis(2-hydroxyethyl)piperazine 2-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]ETHANOL 122-96-3 Building Blocks Piperazines Heterocyclic Building Blocks PIPERIDINE