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1,4-BIS(2-HYDROXYETHYL)PIPERAZINE

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE structure

CAS No.: 122-96-3

Chemical Name:: 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE

Synonyms: 2-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]ETHANOL;AKOS BB-4936;1,4-BIS(2-HYDROXYETH;1,4-PIPERAZINEDIETHANOL;N,N'-PIPERAZINDIETHANOL;N,N'-PIPERAZINEDIETHANOL;piperazine-1,4-diethanol;Piperazine-1,4-bisethanol;DI(HYDROXYETHYL)PIPERAZINE;N,N'-Dihydroxyethylpiperazine

CBNumber:: CB3115114

Molecular Formula:: C8H18N2O2

Molecular Weight:: 174.24

MDL Number:: MFCD00006157

MOL File:: 122-96-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 00:56:05

Product description	Number	Pack Size	Price
1,4-Bis(2-hydroxyethyl)piperazine 99%	B45402	5g	$66.3
1,4-Bis(2-hydroxyethyl)piperazine 99%	B45402	25g	$201
1,4-Bis(2-hydroxyethyl)piperazine >98.0%(GC)(T)	B4903	5g	$32
1,4-Bis(2-hydroxyethyl)piperazine >98.0%(GC)(T)	B4903	25g	$110
1,4-Bis(2-hydroxyethyl)piperazine Asreported	263838	5g	$382
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1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Properties

Melting point	133.5-136 °C(lit.)
Boiling point	215-220 °C50 mm Hg(lit.)
Density	1.097
vapor pressure	0.004Pa at 20℃
refractive index	1.4540 (estimate)
Flash point	166℃
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	powder to crystal
pka	14.66±0.10(Predicted)
color	White to Almost white
Water Solubility	Soluble in water.
InChI	1S/C8H18N2O2/c11-7-5-9-1-2-10(4-3-9)6-8-12/h11-12H,1-8H2
InChIKey	VARKIGWTYBUWNT-UHFFFAOYSA-N
SMILES	OCCN1CCN(CCO)CC1
LogP	-1.92 at 20℃
CAS DataBase Reference	122-96-3(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	EQ349PKX8Y
EPA Substance Registry System	1,4-Piperazinediethanol (122-96-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319

Precautionary statements

P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

PPE

Eyeshields, Gloves, type N95 (US)

Hazard Codes

Risk Statements

36/37/38

Safety Statements

37/39-26

WGK Germany

RTECS

TL3675000

TSCA

TSCA listed

HS Code

2933.59.9500

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Dam. 1

REACH Registrations

Active

NFPA 704

	1
2		0

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE price More Price(57)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B45402	1,4-Bis(2-hydroxyethyl)piperazine 99%	122-96-3	5g	$66.3	2026-04-30	Buy
Sigma-Aldrich	B45402	1,4-Bis(2-hydroxyethyl)piperazine 99%	122-96-3	25g	$201	2026-04-30	Buy
TCI Chemical	B4903	1,4-Bis(2-hydroxyethyl)piperazine >98.0%(GC)(T)	122-96-3	5g	$32	2026-04-30	Buy
TCI Chemical	B4903	1,4-Bis(2-hydroxyethyl)piperazine >98.0%(GC)(T)	122-96-3	25g	$110	2026-04-30	Buy
Usbiological	263838	1,4-Bis(2-hydroxyethyl)piperazine Asreported	122-96-3	5g	$382	2026-06-03	Buy

Product number	Packaging	Price	Buy
B45402	5g	$66.3	Buy
B45402	25g	$201	Buy
B4903	5g	$32	Buy
B4903	25g	$110	Buy
263838	5g	$382	Buy

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

1,4-Piperazinediethanol is useful in the synthesis of salt-inducible kinase inhibitors for the treatment of diseases.

Flammability and Explosibility

Not classified

Synthesis

111-42-2

122-96-3

The general procedure for the synthesis of N,N'-bis(2-hydroxyethyl)piperazine from diethanolamine is as follows: Example 2: Preparation of 1,4-bis(hydroxyethyl)piperazine from diethanolamine under solvent-free conditions Operational steps: 1. 100 g of diethanolamine (II) and 10 g of Catalyst A were added in the same reaction setup described in Example 1 . 2. Upon completion of the reaction, the reaction product was detected by gas chromatography analysis (GC column: 30m RTX Amin). 3. The analytical results showed that the content of 1,4-bis(hydroxyethyl)piperazine in the reaction product was 79% under the condition of complete conversion of diethanolamine.

References

[1] Patent: US2012/108816, 2012, A1. Location in patent: Page/Page column 6
[2] Patent: US2868791, 1954,
[3] Patent: US2636033, 1950,
[4] Patent: DE917784, 1952,

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE synthesis

Synthesis of 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE from Diethanolamine

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Ethanol Sodium sulfate Potassium carbonate Piperazine 2-Chloroethanol

Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide 3-(2-HYDROXYETHYL)-2-OXAZOLIDINONE

ETHYLENE OXIDE 2-Bromoethanol Carbon dioxide

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Preparation Products

1-(2-Hydroxyethyl)piperazine

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Suppliers

Global( 239)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1059@dideu.com	China	29094	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21585	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29812	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19936	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49979	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	sales@tnjchem.com	China	34563	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81139210 +86-17392587031	1059@dideu.com	China	9996	58

Supplier	Advantage
Dideu Industries Group Limited	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
BOC Sciences	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
SIMAGCHEM CORP	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
ANHUI WITOP BIOTECH CO., LTD	58
Shaanxi Dideu Medichem Co. Ltd	58

View Lastest Price from 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-11-18	1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 122-96-3	$1.10	1g	99.9%	100 Tons Min	Dideu Industries Group Limited
2021-07-02	1,4-Bis(2-hydroxyethyl)piperazine 122-96-3	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
2019-07-06	1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 122-96-3	$1.00	1KG	99%		Career Henan Chemical Co

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
122-96-3
$1.10
99.9%
Dideu Industries Group Limited

1,4-Bis(2-hydroxyethyl)piperazine
122-96-3
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
122-96-3
$1.00
99%
Career Henan Chemical Co

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Spectrum

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)MS 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)¹HNMR 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)¹³CNMR 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)IR1 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)IR2 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE(122-96-3)Raman

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DI(HYDROXYETHYL)PIPERAZINE AKOS BB-4936 1,4'-BIS(2-HYDROXYETHYL)PIPERAZINE 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 1,4-PIPERAZINEDIETHANOL 1,4-Bis(beta-hydroxyethyl)piperazine 1,4-Di(2-hydroxyethyl)piperazine n,n’-bis(2-hydroxyethyl)-piperazin n,n’-bis(beta-hydroxyethyl)piperazine n,n’-di(2-hydroxyethyl)piperazine N,N'-Bis(beta-hydroxyethyl)piperazine N,N'-Di(2-hydroxyethyl)piperazine N,N'-Dihydroxyethylpiperazine Piperazine, N,N'-bis(2-hydroxyethyl)- N,N'-PIPERAZINDIETHANOL N,N'-PIPERAZINEDIETHANOL piperazine,N,N’-bis(2-hydroxyethyl)- piperazine-1,4-diethanol 1,4-Piperazinediethanol(6CI,7CI,8CI,9CI) 2,2''-PIPERAZINE-1,4-DIYLDIETHANOL 2,2'-(1,4-Piperazinediyl)diethanol Piperazine-1,4-bisethanol N,N'-Bis(2-hydroxyethyl)piperazine,99% 1,4-Bis(2-hydroxyethyl)piperazine,1,4-Piperazinediethanol 1,4-BIS(2-HYDROXYETH 1,4-Bis(2-hydroxyethyl)piperazine 1,4-Bis(2-hydroxyethyl)piperazine 99% 1,4-Bis(2-hydroxyethyl)piperazine > 1,4-Bis(2-hydroxyethyl)piperazine,98% 4-BIS(2-HYDROXYETHYL)PIPERAZINE TIANFU CHEM 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 1,4-Piperazinediethanol (6CI, 7CI, 8CI, 9CI, ACI) n,n'-bis(2-hydroxyethyl)piperazine 2,2'-(Piperazine-1,4-diyl)diethanol N,N'-Bis(2-hydroxyethyl)piperazine 2-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]ETHANOL 122-96-3 Building Blocks Piperazines Heterocyclic Building Blocks PIPERIDINE