6-Amino-3-methyluracil
- CAS No.
- 21236-97-5
- Chemical Name:
- 6-Amino-3-methyluracil
- Synonyms
- Urapidil Impurity 73;3-Methyl-6-aMinouracil;6-Amino-3-methyluracil ,97%;6-Amino-3-methyluracil 95+%;6-Amino-3-methylpyrimidine-2,4(1H,3H);6-Amino-3-methyl-1H-pyrimidine-2,4-dione;Urapidil Impurity 15（6-Amino-3-methyluracil）;2,4(1H,3H)-Pyrimidinedione, 6-amino-3-methyl-;6-amino-3-methyldihydropyrimidine-2,4(1H,3H)-dione
- CBNumber:
- CB31176013
- Molecular Formula:
- C5H7N3O2
- Molecular Weight:
- 141.13
- MDL Number:
- MFCD02091062
- MOL File:
- 21236-97-5.mol
- MSDS File:
- SDS
| Melting point | 350-352°C |
|---|---|
| Density | 1.339±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly), Water |
| form | Solid |
| pka | 8.94±0.40(Predicted) |
| color | Off-White to Pale Yellow |
| InChI | InChI=1S/C5H7N3O2/c1-8-4(9)2-3(6)7-5(8)10/h2H,6H2,1H3,(H,7,10) |
| InChIKey | JGAVPFNFAUWIJY-UHFFFAOYSA-N |
| SMILES | C1(=O)NC(N)=CC(=O)N1C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338-P302+P352-P321-P405-P501 |
| Risk Statements | 20/21/22 |
| Safety Statements | 24/25-36/37 |
| HS Code | 29335990 |
6-Amino-3-methyluracil price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | TRC-A618275-1G | 6-Amino-3-methyluracil | 21236-97-5 | 1g | $690 | 2026-06-03 | Buy |
| Apolloscientific | OR301307 | 6-Amino-3-methyluracil >97% | 21236-97-5 | 250mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR301307 | 6-Amino-3-methyluracil >97% | 21236-97-5 | 1g | $24 | 2026-06-04 | Buy |
| Apolloscientific | OR301307 | 6-Amino-3-methyluracil >97% | 21236-97-5 | 5g | $113 | 2026-06-04 | Buy |
| Apolloscientific | OR301307 | 6-Amino-3-methyluracil >97% | 21236-97-5 | 25g | $546 | 2026-06-04 | Buy |
6-Amino-3-methyluracil Chemical Properties, Uses, Production
Chemical Properties
Off-White to Yellow Solid
Synthesis
873-83-6
74-88-4
21236-97-5
4-Amino-2,6-dihydroxypyrimidine (5.18 g, 40.7 mmol) was suspended in hexamethyldisilazane (HMDS, 25 mL) and concentrated sulfuric acid (H2SO4, 0.1 mL) was added. The reaction mixture was heated to reflux for 3 h and subsequently concentrated under vacuum. The residue was dissolved in N,N-dimethylformamide (DMF, 30 mL), iodomethane (MeI, 8.5 mL, 136.5 mmol) was added and stirred continuously for 72 hours at room temperature. Upon completion of the reaction, the mixture was cooled to 0°C and sodium bicarbonate (NaHCO3) was slowly added to neutralize the reaction. Stirring was continued at 0°C until no further gas production was observed. The precipitate was collected by filtration, washed sequentially with methanol (MeOH) and water (H2O), and dried to afford 6-amino-3-methylpyrimidine-2,4(1H,3H)-dione (4.49 g, 78% yield) as a yellow solid, which could be used in the subsequent reaction without further purification. The Rf value of thin layer chromatography (TLC) was 0.23 (Expanding agent: ethyl acetate-methanol-ammonia, 7:2.7:0.3). Nuclear magnetic resonance hydrogen spectrum (1H NMR, 400 MHz, DMSO-d6) δ 10.36 (1H, single peak, NH), 6.16 (2H, single peak, NH2), 4.56 (1H, single peak, H-5), 3.04 (3H, single peak, NCH3). Nuclear magnetic resonance carbon spectrum (13C NMR, 100 MHz, DMSO-d6) δ 163.3 (C-4), 153.5 (C-6), 151.1 (C-2), 74.0 (C-5), 25.9 (NCH3). Melting point (MP): literature value 327°C, measured value 320-323°C.
References
[1] Journal of Agricultural and Food Chemistry, 2016, vol. 64, # 24, p. 5079 - 5084
[2] Patent: WO2017/99612, 2017, A1. Location in patent: Page/Page column 8; 28
[3] Patent: WO2014/143799, 2014, A2. Location in patent: Page/Page column 372
[4] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 5, p. 2001 - 2009
6-Amino-3-methyluracil Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Jingjinchem Co., Ltd. | 021-13817626287 13817626287 | 1094777898@qq.com | China | 110 | 55 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| Suzhou Guide Fine Material Co.Ltd. | 0512-66627360 13914021065 | 706938434@qq.com | China | 202 | 60 |
| Shanghai SynFarm Pharmaceutical Technology Co., Ltd. | 021-50793966 18917198199 | info@synfarm.com | China | 280 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
View Latest Price from 6-Amino-3-methyluracil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-06-30 | Titanium dioxide
21236-97-5
|
1kg | 98% | 1000kg | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2020-05-15 | 6-Amino-3-methyluracil
21236-97-5
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2019-07-06 | 6-Amino-3-methyluracil
21236-97-5
|
$1.00 | 1KG | 99% | Career Henan Chemical Co |
-
- Titanium dioxide
21236-97-5
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 6-Amino-3-methyluracil
21236-97-5
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 6-Amino-3-methyluracil
21236-97-5
- $1.00
- 99%
- Career Henan Chemical Co
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