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PROTAC HPK1 Degrader-1

PROTAC HPK1 Degrader-1 Structure
PROTAC HPK1 Degrader-1 structure
CAS No.
3034182-97-0
Chemical Name:
PROTAC HPK1 Degrader-1
Synonyms
PROTAC HPK1 Degrader-1;1H-Isoindole-1,3(2H)-dione, 4-[[2-[3-[4-[4-[3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-
CBNumber:
CB314286596
Molecular Formula:
C43H43N7O8
Molecular Weight:
785.85
MDL Number:
MOL File:
3034182-97-0.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:03
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PROTAC HPK1 Degrader-1 Properties

Density 1.378±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka 10.74±0.40(predicted)

PROTAC HPK1 Degrader-1 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-1010552 PROTAC HPK1 Degrader-1 99.70% 3034182-97-0 5mg $406 2026-06-04 Buy
ChemScene CS-1010552 PROTAC HPK1 Degrader-1 99.70% 3034182-97-0 10mg $650 2026-06-04 Buy
ChemScene CS-1010552 PROTAC HPK1 Degrader-1 99.70% 3034182-97-0 25mg $1219 2026-06-04 Buy
ChemScene CS-1010552 PROTAC HPK1 Degrader-1 99.70% 3034182-97-0 50mg $1950 2026-06-04 Buy
Arctom HY-163372 PROTAC HPK1 Degrader-1 99.70% 3034182-97-0 5mg $357 2026-05-26 Buy
Product number Packaging Price Buy
CS-1010552 5mg $406 Buy
CS-1010552 10mg $650 Buy
CS-1010552 25mg $1219 Buy
CS-1010552 50mg $1950 Buy
HY-163372 5mg $357 Buy

PROTAC HPK1 Degrader-1 Chemical Properties, Uses, Production

Uses

PROTAC HPK1 Degrader-1 (Compound B1) is a potent HPK1 degrader with DC50 value of 1.8 nM. PROTAC HPK1 Degrader-1 inhibits phosphorylation of the SLP76 protein with IC50 value of 496.1 nM. PROTAC HPK1 Degrader-1 is a bona fide HPK1-PROTAC degrader, which provided a potential tool for further HPK1 investigation in TCR signaling[1].

References

[1] Zeng S, et al. Discovery of highly efficient CRBN-recruiting HPK1-PROTAC as a potential chemical tool for investigation of scaffolding roles in TCR signaling. Bioorg Chem. 2024 Feb;143:107016. DOI:10.1016/j.bioorg.2023.107016

PROTAC HPK1 Degrader-1 Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC HPK1 Degrader-1 Suppliers

Global Suppliers ( 1)
Supplier Tel Email Country ProdList Advantage
19011298796 19011298796 17816380947@139.com China 472 58
Supplier Advantage
58

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PROTAC HPK1 Degrader-1 1H-Isoindole-1,3(2H)-dione, 4-[[2-[3-[4-[4-[3-(3,4-dimethoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)- 3034182-97-0 PROTACs-Please select