Dimethyl itaconate
- CAS No.
- 617-52-7
- Chemical Name:
- Dimethyl itaconate
- Synonyms
- DIMETHYL 2-METHYLENESUCCINATE;DIMETHYL METHYLENESUCCINATE;Butanedioic acid, methylene-, dimethyl ester;C7H10O4;109533-100G;ized with HQ);METHYL ITACONATE;Dimethylitaconat;Itaconate (stabiL;DIMETHYL ITACONATE
- CBNumber:
- CB3147485
- Molecular Formula:
- C7H10O4
- Molecular Weight:
- 158.15
- MDL Number:
- MFCD00008446
- MOL File:
- 617-52-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 37-41 °C (lit.) |
|---|---|
| Boiling point | 208 °C (lit.) |
| Density | 1.124 g/mL at 25 °C (lit.) |
| vapor pressure | 4.05Pa at 20℃ |
| refractive index | 1.4457 (estimate) |
| Flash point | 213 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
| form | Crystalline Low Melting Mass or Liquid |
| Specific Gravity | 1.124 |
| color | White |
| Water Solubility | slightly soluble |
| BRN | 386674 |
| Cosmetics Ingredients Functions |
HAIR CONDITIONING SKIN PROTECTING SKIN CONDITIONING - MISCELLANEOUS ANTIOXIDANT |
| InChI | 1S/C7H10O4/c1-5(7(9)11-3)4-6(8)10-2/h1,4H2,2-3H3 |
| InChIKey | ZWWQRMFIZFPUAA-UHFFFAOYSA-N |
| SMILES | COC(=O)CC(=C)C(=O)OC |
| LogP | 0.86 at 25℃ |
| CAS DataBase Reference | 617-52-7(CAS DataBase Reference) |
| FDA UNII | 11JIB0YI93 |
| NIST Chemistry Reference | Butanedioic acid, methylene-, dimethyl ester(617-52-7) |
| EPA Substance Registry System | Butanedioic acid, 2-methylene-, 1,4-dimethyl ester (617-52-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29171900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Skin Irrit. 2 Skin Sens. 1B |
|||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Dimethyl itaconate price More Price(70)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 109533 | Dimethyl itaconate 97% | 617-52-7 | 100g | $76.3 | 2026-04-30 | Buy |
| Sigma-Aldrich | 109533 | Dimethyl itaconate 97% | 617-52-7 | 500g | $182 | 2026-04-30 | Buy |
| TCI Chemical | I0206 | Dimethyl Itaconate (stabilized with HQ) >98.0%(GC) | 617-52-7 | 25g | $26 | 2026-04-30 | Buy |
| TCI Chemical | I0206 | Dimethyl Itaconate (stabilized with HQ) >98.0%(GC) | 617-52-7 | 500g | $110 | 2026-04-30 | Buy |
| TRC | TRC-D474205-5G | Dimethyl Itaconate | 617-52-7 | 5g | $84 | 2026-06-03 | Buy |
Dimethyl itaconate Chemical Properties, Uses, Production
Chemical Properties
white crystalline low melting mass or liquid
Uses
Dimethyl Itaconate is a chemical reagent used in the synthesis of functionalized 2-isoxazolines used in fragment-based drug discovery.
Uses
Dimethyl itaconate may be used in functionalization of isotactic poly(propylene). It was used in crosslinking of polyesters: poly(isosorbide itaconate)and poly(isosorbide itaconate-co-succinate).
Uses
Dimethyl itaconate can be used for the rhodium catalyzed asymmetric hydrogenation of (S)-dimethyl-2-methylsuccinate and (R)-methyl succinic acid dimethyl ester.
General Description
Dimethyl itaconate undergoes enantioselective Rh(I)-catalyzed hydrogenation which can be enhanced by appropriate choice of substituents on aromatic ring of (1,2-diarylphosphinoxy)cyclohexane.
Flammability and Explosibility
Non flammable
Synthesis
67-56-1
97-65-4
617-52-7
1. Itaconic acid, methanol and catalyst were mixed in a certain ratio and transferred to a 100 mL autoclave. 2. The reaction mixture was continuously stirred at 120 °C. 3. Optimization of the reaction conditions was carried out by adjusting the parameters such as the molar ratio of methanol to itaconic acid, the catalyst dosage and the reaction time. 4. Upon completion of the reaction, the catalyst was separated and recovered through a filtration operation.
Purification Methods
Crystallise the ester from MeOH by cooling to -78o. [Beilstein 2 IV 2229.]
References
[1] Journal of Molecular Catalysis A: Chemical, 2013, vol. 368-369, p. 24 - 30
[2] Heterocycles, 1988, vol. 27, # 8, p. 1887 - 1898
[3] Tetrahedron Letters, 2015, vol. 56, # 27, p. 4119 - 4123
[4] Chemistry and physics of lipids, 2002, vol. 120, # 1-2, p. 9 - 20
[5] Russian Chemical Bulletin, 2005, vol. 54, # 2, p. 348 - 353
Dimethyl itaconate Preparation Products And Raw materials
Raw materials
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shandong Vantage Specialty Chemicals Biotechnology Co., Ltd. | 13396369453 18678026865 | sdfantai@163.com | China | 904 | 58 |
| Shandong Xibang Biological Technology Development Co. LTD | 0536-3611186 15063661551 | 196056703@qq.com | China | 59 | 58 |
| Weifang Siyuan Chemical Co., Ltd. | 0536-8888106 17663601818 | 2354379876@qq.com | China | 244 | 58 |
| Shijiazhuang Ruitian Biochemical Co. Ltd | 15831127780 | 52714113@qq.com | China | 2361 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| HanerChem | 020-82488509,13928734585 | China | 41 | 55 | |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
View Latest Price from Dimethyl itaconate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-10-14 | Dimethyl itaconate
617-52-7
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2026-08-14 | Dimethyl itaconate
617-52-7
|
$29.00 | 98.36% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-06-30 | Dimethyl itaconate
617-52-7
|
1kg | 99% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- Dimethyl itaconate
617-52-7
- $0.00
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Dimethyl itaconate
617-52-7
- $29.00
- 98.36%
- TargetMol Chemicals Inc.
-
- Dimethyl itaconate
617-52-7
- $0.00
- 99%
- Shaanxi Dideu New Materials Co. Ltd
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