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Z-Tyr(Bzl)-OH

Z-Tyr(Bzl)-OH Structure
Z-Tyr(Bzl)-OH structure
CAS No.
16677-29-5
Chemical Name:
Z-Tyr(Bzl)-OH
Synonyms
Cbz-Tyr(bzl);Z-Tyr(Bzl)-OH;CBZ-TYR(BZL)-OH;Z-L-Tyr(Bzl)-OH;Cbz-L-Tyr(Bzl)-OH;CBZ-O-BENZYL-L-TYR;Z-TYROSINE(BZL)-OH;Z-O-BENZYL-L-TYROSINE;CBZ-O-BENZYL-L-TYROSINE;Z-O-Benzyl-L-tyrosine, 98%+
CBNumber:
CB3175990
Molecular Formula:
C24H23NO5
Molecular Weight:
405.44
MDL Number:
MFCD00037819
MOL File:
16677-29-5.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:51:45
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Z-Tyr(Bzl)-OH Properties

Melting point 128-130 °C
Boiling point 624.4±55.0 °C(Predicted)
Density 1.249±0.06 g/cm3(Predicted)
storage temp. Store at 0°C
solubility Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form Solid
pka 2.98±0.10(Predicted)

SAFETY

Risk and Safety Statements

WGK Germany  3
NFPA 704
1
0 0

Z-Tyr(Bzl)-OH price More Price(51)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 264675 Z-O-benzyl-L-tyrosine Asreported 16677-29-5 5g $360 2026-06-03 Buy
Usbiological 264675 Z-O-benzyl-L-tyrosine Asreported 16677-29-5 10g $498 2026-06-03 Buy
Usbiological 264675 Z-O-benzyl-L-tyrosine Asreported 16677-29-5 25g $666 2026-06-03 Buy
Usbiological 264675 Z-O-benzyl-L-tyrosine Asreported 16677-29-5 50g $1020 2026-06-03 Buy
Usbiological 264675 Z-O-benzyl-L-tyrosine Asreported 16677-29-5 100g $1427 2026-06-03 Buy
Product number Packaging Price Buy
264675 5g $360 Buy
264675 10g $498 Buy
264675 25g $666 Buy
264675 50g $1020 Buy
264675 100g $1427 Buy

Z-Tyr(Bzl)-OH Chemical Properties,Uses,Production

Synthesis

H-TYR(BZL)-OH

16652-64-5

Benzyl chloroformate

501-53-1

Tyrosine, N-[(phenylmethoxy)carbonyl]-O-(phenylmethyl)-

86827-18-1

General procedure for the synthesis of the compound (CAS: 86827-18-1) from O-benzyl-L-tyrosine and benzyl chloroformate: (S)-O-benzyl-tyrosine (8.14 g, 30 mmol) was dissolved in THF (60 mL) and cooled to 0 °C. Subsequently, an aqueous solution of NaOH (3 g, 75 mmol) was added (60 mL). A solution of benzyl chloroformate (4.65 mL, 5.63 g, 33 mmol) in THF (30 mL) was slowly added dropwise at 0 °C. The reaction mixture was stirred at 0 °C for 2 h, then gradually warmed to room temperature and continued stirring overnight. After the reaction was completed, water (50 mL) was added and the pH was adjusted to 1-2 with 10% HCl, then the aqueous phase was extracted with EtOAc (3 × 100 mL). The organic phases were combined, washed with brine (2 × 100 mL) and dried over Na2SO4. The solvent was removed by concentration under reduced pressure to give pure (S)-N-Benzyloxycarbonyl-O-benzyl-tyrosine (11.57 g, 95% yield) as a pale yellow solid, melting point: 128-130°C. The product could be used in the next reaction without further purification.1H NMR (400 MHz, CDCl3) δ: 2.85 (dd, J = 13.2, 8.4 Hz, 1H, CH2), 3.10 (dd, J = 13.2, 12.0 Hz, 1H, CH2), 4.43 (dd, J = 12.0, 8.4 Hz, 1H, CH). 4.80 (d, J = 12.4 Hz, 1H, CH2O), 4.82 (s, 2H, CH2O), 5.00 (d, J = 12.4 Hz, 1H, CH2O), 5.60 (d, J = 4.8 Hz, 1H, NH), 6.65-7.35 (m, 14H, ArH).13C NMR (100 MHz, CDCl3) δ : 36.9, 56.2, 66.8, 69.8, 114.8, 127.5, 127.83, 127.89, 127.93, 128.4, 128.5, 128.9, 130.3, 136.2, 137.0, 156.6, 157.7, 177.5. HRMS (ESI) C24H24NO5 [M + H ]+ m/z calculated value: 406.1649; measured value: 406.1641.

References

[1] Tetrahedron, 2014, vol. 70, # 34, p. 5197 - 5206
[2] Chemische Berichte, 1958, vol. 91, p. 542,546
[3] Monatshefte fuer Chemie, 1974, vol. 105, p. 1110 - 1135

Z-Tyr(Bzl)-OH Preparation Products And Raw materials

Raw materials

Z-Tyr-OH H-Tyr(Bzl)-OH Benzyl chloroformate Benzyl bromide Water
Sodium hydroxide Tetrahydrofuran

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Preparation Products

Z-Tyr(Bzl)-OH Suppliers

Global( 164)Suppliers
Supplier Tel Email Country ProdList Advantage
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
GL Biochem (Shanghai) Ltd 21-61263452 13641803416 ymbetter@glbiochem.com China 9981 64
Capot Chemical Co., Ltd +86 (0) 571 85 58 67 18 China 18187 66
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Chemsky (shanghai) International Co.,Ltd 021-50135380 shchemsky@sina.com China 15350 60
ChemPep, Inc. +1 (888) 615-9178 / (561) 791-8787 service@chempep.com United States 2138 57
Beijing HuaMeiHuLiBiological Chemical 010-56205725 waley188@sohu.com China 12323 58
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 22497 55
Supplier Advantage
Alfa Aesar 84
Energy Chemical 61
GL Biochem (Shanghai) Ltd 64
Capot Chemical Co., Ltd 66
Adamas Reagent, Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Chemsky (shanghai) International Co.,Ltd 60
ChemPep, Inc. 57
Beijing HuaMeiHuLiBiological Chemical 58
9ding chemical ( Shanghai) Limited 55

View Lastest Price from Z-Tyr(Bzl)-OH manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Z-TYR(BZL)-OH pictures 2019-07-06 Z-TYR(BZL)-OH
16677-29-5
 $1.00 1KG 99% 20kg Career Henan Chemical Co
Z-TYR(BZL)-OH pictures 2019-07-06 Z-TYR(BZL)-OH
16677-29-5
 $7.00 1KG 99% 100KG Career Henan Chemical Co

16677-29-5(Z-Tyr(Bzl)-OH)Related Search:

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N-ALPHA-CBZ-O-BENZYL-L-TYROSINE N-ALPHA-CARBOBENZOXY-O-BENZYL L-TYROSINE N-CARBOBENZOXY-O-BENZYL-L-TYROSINE Z-O-BENZYL-L-TYROSINE Z-TYROSINE(BZL)-OH CBZ-(S)-2-AMINO-3-(4'-BENZYLOXYPHENYL)PROPANOIC ACID CBZ-O-BENZYL-L-TYR CBZ-O-BENZYL-L-TYROSINE CBZ-TYR(BZL)-OH BENZYLOXYCARBONYL-O-BENZYL-L-TYROSINE (2S)-2-{[(benzyloxy)carbonyl]aMino}-3-[4-(benzyloxy)phenyl]propanoic acid N-Benzyloxycarbonyl-O-benzyl-L-tyrosine N-CBZ-O-BENZYL-L-TYROSINE CRYSTALLINE N-alpha-Benzyloxycarbonyl-O-benzyl-L-tyrosine Z-L-Tyr(Bzl)-OH (S)-3-(4-(benzyloxy)phenyl)-2-(benzyloxycarbonylamino)propanoic acid Cbz-L-Tyr(Bzl)-OH Z-O-benzyl-L-tyrosine≥ 98% (HPLC) (S)-2-(((Benzyloxy)carbonyl)aMino)-3-(4-(benzyloxy)phenyl)propanoic acid 2-(phenylmethoxycarbonylamino)-3-(4-phenylmethoxyphenyl)propanoic acid L-Tyrosine, N-[(phenylmethoxy)carbonyl]-O-(phenylmethyl)- Z-O-Benzyl-L-tyrosine, 98%+ Z-O-Benzyl-L-Tyrosine extrapure, 98% Z-O-Benzyl-L-Tyrosine, Extra Pure, 98% Cbz-Tyr(bzl) Z-Tyr(Bzl)-OH 16677-29-5 Amino Acid Derivatives Peptide Synthesis Specialty Synthesis Tyrosine