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Z-Trp-Trp-OH

Z-Trp-Trp-OH structure

CAS No.: 57850-17-6

Chemical Name:: Z-Trp-Trp-OH

Synonyms: Z-Trp-Trp-OH;Cbz-Trp-Trp-OH;Z-Trp-Trp-OH≥ 98% (HPLC);L-Tryptophan, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-;(S)-2-[(S)-2-(Cbz-amino)-3-(3-indolyl)propanamido]-3-(3-indolyl)propanoic Acid;(2S)-3-(1H-indol-3-yl)-2-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoic acid

CBNumber:: CB6309406

Molecular Formula:: C30H28N4O5

Molecular Weight:: 524.57

MDL Number:: MFCD00022760

MOL File:: 57850-17-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:11

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Z-Trp-Trp-OH Properties

storage temp.	Sealed in dry,2-8°C

Z-Trp-Trp-OH price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	291164	Z-Trp-Trp-OH Asreported	57850-17-6	250mg	$382	2026-06-03	Buy
Usbiological	291164	Z-Trp-Trp-OH Asreported	57850-17-6	500mg	$581	2026-06-03	Buy
Usbiological	291164	Z-Trp-Trp-OH Asreported	57850-17-6	1g	$819	2026-06-03	Buy
Usbiological	242924	Z-Trp-Trp-OH 99+% ≥99%	57850-17-6	100mg	$200	2026-06-03	Buy
Usbiological	242924	Z-Trp-Trp-OH 99+% ≥99%	57850-17-6	250mg	$252	2026-06-03	Buy

Product number	Packaging	Price	Buy
291164	250mg	$382	Buy
291164	500mg	$581	Buy
291164	1g	$819	Buy
242924	100mg	$200	Buy
242924	250mg	$252	Buy

Z-Trp-Trp-OH Chemical Properties, Uses, Production

Chemical Properties

White to off-white powder

Synthesis

L-Tryptophan, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-, methyl ester

17689-58-6

57850-17-6

Cbz-tryptophanyl-tryptophan was synthesized from the compound (CAS: 17689-58-6) using the saponification method of McDermott et al. (Journal of the American Chemical Society 1982, 104, 3002-3007). The procedure is as follows: the di-protected dipeptide (0.425 g, 0.79 mmol) is dissolved in methanol (20 mL), followed by the addition of 1N NaOH (5 mL) to the solution. The reaction scale could be expanded to twofold or threefold as required without affecting the progress of the reaction. The progress of the reaction was monitored by TLC during the reaction. After 2 hours of reaction, water (20 mL) was added and washed with ether (2 x 20 mL) to remove unreacted material. Subsequently, the aqueous layer was acidified with concentrated hydrochloric acid to pH 2. Hydrochloric acid and ethyl acetate (20 mL) were added rapidly to separate the ethyl acetate layer, and the aqueous layer was then extracted with two parts of ethyl acetate (20 mL). The organic phases were combined, dried over magnesium sulfate and concentrated, and the resulting oil was recrystallized by ethyl acetate/hexane and subsequently recrystallized again from methanol/water. The final white solid obtained was dried under vacuum. The product was Cbz-Trp-Trp-OH (Cbz-L-Trp-L-Trp-OH) as a white solid (0.257 g, 87.3% yield) with a melting point of 207-210 °C (literature value 209-210 °C) and [α]D25 +19.2 (c 0.8 in acetic acid; literature value +23.7, c 0.8 in acetic acid).TLC analysis showed Rf values A: 0.74, B: 0.69. IR spectrum (vmax) showed characteristic absorption peaks: 3412 (NH), 3372 (NH), 3334 (NH), 3054 (aromatic CH), 2921 (CH), 1729 (COOH), 1695 (C=O), 1659 (C=O), 1515 (aromatic C=C) cm -1. Nuclear magnetic resonance hydrogen (1H NMR) and carbon (13C NMR) spectral data were consistent with the structure. The mass spectrum (FAB) showed the molecular ion peak m/z: 525.2 [M+H]+.

References

[1] Patent: WO2006/125324, 2006, A1. Location in patent: Page/Page column 128-129
[2] Tetrahedron Letters, 1982, vol. 23, # 19, p. 1985 - 1988

Z-Trp-Trp-OH Preparation Products And Raw materials

Raw materials

L-Tryptophan, N-[(phenylmethoxy)carbonyl]-L-tryptophyl-, methyl ester Hydrochloric acid

Preparation Products

Z-Trp-Trp-OH Suppliers

Global Suppliers ( 44)

Supplier	Tel	Email	Country	ProdList	Advantage
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
Wuxi Asia Peptide Biotechnology Limited Company	0510-83583050 13771062561	willsun@peptide-search.com	China	6713	58
Nanjing Peptide Biotech Ltd.	025-58361106-805 15951641583	zhao.xu@njpeptide.com	China	9976	55
Chengdu Youngshe Chemical Co., Ltd.	+86-17380623303	Caroline@youngshechem.com	China	4726	58
Aikon International Limited	025-58851090 13913916777	sales01@aikonchem.com	China	15947	58
Shanghai Jizhi Biochemical Technology Co. Ltd.	021-4009004166/18616739031 18616739031	3007523370@qq.com	China	40000	58
Shanghai Jifeng Biotechnology Co., Ltd.	021-61263377 15023907684	15800684150@163.com	China	7994	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19904	58

Supplier	Advantage
GL Biochem (Shanghai) Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
Wuxi Asia Peptide Biotechnology Limited Company	58
Nanjing Peptide Biotech Ltd.	55
Chengdu Youngshe Chemical Co., Ltd.	58
Aikon International Limited	58
Shanghai Jizhi Biochemical Technology Co. Ltd.	58
Shanghai Jifeng Biotechnology Co., Ltd.	58
Nextpeptide Inc	58

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Z-Trp-Trp-OH≥ 98% (HPLC) (2S)-3-(1H-indol-3-yl)-2-[[(2S)-3-(1H-indol-3-yl)-2-(phenylmethoxycarbonylamino)propanoyl]amino]propanoic acid L-Tryptophan, N-[(phenylmethoxy)carbonyl]-L-tryptophyl- Cbz-Trp-Trp-OH (S)-2-[(S)-2-(Cbz-amino)-3-(3-indolyl)propanamido]-3-(3-indolyl)propanoic Acid Z-Trp-Trp-OH 57850-17-6 C30H28N4O5