2-Hydroxy-4-methyl-5-nitropyridine
- CAS No.
- 21901-41-7
- Chemical Name:
- 2-Hydroxy-4-methyl-5-nitropyridine
- Synonyms
- 4-Methyl-5-nitropyridin-2(1H)-one;2-HYDROXY-5-NI;5-NITRO-4-PICOLIN-2-OL;4-METHYL-5-NITRO-2-PYRIDONE;4-METHYL-5-NITRO-2-PYRIDINOL;2-HYDROXY-5-NITRO-4-PICOLINE;4-Methyl-5-nitro-2-pyridinone;2-Hydroxy-4-Methyl-5-Nitropyri;4-METHYL-5-NITRO-2(1H)-PYRIDINONE;4-methyl-5-nitro-1H-pyridin-2-one
- CBNumber:
- CB3193376
- Molecular Formula:
- C6H6N2O3
- Molecular Weight:
- 154.12
- MDL Number:
- MFCD00010690
- MOL File:
- 21901-41-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 186-190 °C (lit.) |
|---|---|
| Boiling point | 277.46°C (rough estimate) |
| Density | 1.4564 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | Crystalline Powder |
| pka | 8.10±0.10(Predicted) |
| color | Yellow to orange |
| BRN | 136900 |
| InChI | 1S/C6H6N2O3/c1-4-2-6(9)7-3-5(4)8(10)11/h2-3H,1H3,(H,7,9) |
| InChIKey | AIEHUZHKFUNHCJ-UHFFFAOYSA-N |
| SMILES | Cc1cc(O)ncc1[N+]([O-])=O |
| CAS DataBase Reference | 21901-41-7(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi,Xn | |||||||||
| Risk Statements | 36/37/38-20/21/22 | |||||||||
| Safety Statements | 26-37/39-36/37/39-36 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29337900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
2-Hydroxy-4-methyl-5-nitropyridine price More Price(55)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 290106 | 2-Hydroxy-4-methyl-5-nitropyridine 98% | 21901-41-7 | 5g | $185 | 2023-01-07 | Buy |
| TCI Chemical | H1050 | 2-Hydroxy-4-methyl-5-nitropyridine >98.0%(GC)(T) | 21901-41-7 | 1g | $25 | 2026-04-30 | Buy |
| TCI Chemical | H1050 | 2-Hydroxy-4-methyl-5-nitropyridine >98.0%(GC)(T) | 21901-41-7 | 5g | $78 | 2026-04-30 | Buy |
| AstaTech | 25840 | 2-HYDROXY-4-METHYL-5-NITROPYRIDINE 97% | 21901-41-7 | 25G | $93 | 2026-04-30 | Buy |
| AstaTech | 25840 | 2-HYDROXY-4-METHYL-5-NITROPYRIDINE 97% | 21901-41-7 | 100G | $233 | 2026-04-30 | Buy |
2-Hydroxy-4-methyl-5-nitropyridine Chemical Properties, Uses, Production
Chemical Properties
Orange plates
Uses
The conformational stability and the vibartional analysis of 2-hydroxy-4-methyl-5-nitropyridine was studied.
General Description
The conformational stability and the vibartional analysis of 2-hydroxy-4-methyl-5-nitropyridine was studied.
Synthesis
21901-40-6
21901-41-7
General procedure for the synthesis of 2-hydroxy-4-methyl-5-nitropyridine from 2-amino-4-methyl-5-nitropyridine: 2-amino-4-methyl-5-nitropyridine (10 g, 23 mmol) was weighed and placed in a 250 ml round-bottomed flask, and 70 ml of concentrated sulphuric acid was added to dissolve it until the raw material was completely dissolved. The reaction flask was placed in a cold bath at a low temperature of -5 °C, and a pre-configured aqueous solution of sodium nitrite (NaNO2, 6.76 g) was slowly added dropwise through a constant pressure dropping funnel. A large number of bubbles were generated during the addition, and the rate of titration needed to be controlled to avoid a rapid increase in temperature and to ensure that the reaction temperature did not exceed 0 °C. The reaction was carried out at a constant pressure. A solid was gradually precipitated during the reaction. After dropwise addition, stirring was continued for 10 minutes, and the reaction solution turned orange and clarified. The reaction was continued at 0 °C and the progress of the reaction was monitored by thin layer chromatography (TLC).The reaction was stopped after 3 hours when the TLC showed that the reaction was complete. The reaction solution was slowly poured into a beaker containing about 300 mL of water and a large amount of yellow solid precipitated. After leaving to crystallize for 3 h at room temperature, the solid was collected by filtration and dried under infrared lamp to give 6.72 g of yellow solid product in 67.2% yield.
References
[1] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0045
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 13
[3] Journal of the Chemical Society, 1954, p. 2448,2455
[4] Journal of Organic Chemistry, 1955, vol. 20, p. 1729,1731
[5] Patent: WO2007/53394, 2007, A1. Location in patent: Page/Page column 12
2-Hydroxy-4-methyl-5-nitropyridine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Latest Price from 2-Hydroxy-4-methyl-5-nitropyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Hydroxy-4-methyl-5-nitropyridine
21901-41-7
|
$5.00 | 1KG | 98% | Henan Fengda Chemical Co., Ltd | ||
 |
2026-08-20 | 2-Hydroxy-4-methyl-5-nitropyridine
21901-41-7
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2026-06-30 | 2-Hydroxy-4-methyl-5-nitropyridine
21901-41-7
|
1KG | 98.0% | 10000KGS | Shaanxi Dideu New Materials Co. Ltd |
-
- 2-Hydroxy-4-methyl-5-nitropyridine
21901-41-7
- $5.00
- 98%
- Henan Fengda Chemical Co., Ltd
-
- 2-Hydroxy-4-methyl-5-nitropyridine
21901-41-7
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Hydroxy-4-methyl-5-nitropyridine
21901-41-7
- 98.0%
- Shaanxi Dideu New Materials Co. Ltd
