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2-Hydroxy-4-methyl-5-nitropyridine

2-Hydroxy-4-methyl-5-nitropyridine Structure
2-Hydroxy-4-methyl-5-nitropyridine structure
CAS No.
21901-41-7
Chemical Name:
2-Hydroxy-4-methyl-5-nitropyridine
Synonyms
2-HYDROXY-5-NI;5-NITRO-4-PICOLIN-2-OL;4-METHYL-5-NITRO-2-PYRIDONE;4-METHYL-5-NITRO-2-PYRIDINOL;2-HYDROXY-5-NITRO-4-PICOLINE;4-Methyl-5-nitro-2-pyridinone;2-Hydroxy-4-Methyl-5-Nitropyri;4-METHYL-5-NITRO-2(1H)-PYRIDINONE;4-Methyl-5-nitropyridin-2(1H)-one;4-methyl-5-nitro-1H-pyridin-2-one
CBNumber:
CB3193376
Molecular Formula:
C6H6N2O3
Molecular Weight:
154.12
MDL Number:
MFCD00010690
MOL File:
21901-41-7.mol
MSDS File:
SDS
Last updated:2026-01-13 13:16:52
Product description Number Pack Size Price
2-Hydroxy-4-methyl-5-nitropyridine 98% 290106 5g $185
2-Hydroxy-4-methyl-5-nitropyridine >98.0%(GC)(T) H1050 1g $25
2-Hydroxy-4-methyl-5-nitropyridine >98.0%(GC)(T) H1050 5g $78
4-Methyl-5-nitro-1,2-dihydropyridin-2-one M218915 100mg $75
2-Hydroxy-4-methyl-5-nitropyridine 98% 024735 100g $178
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2-Hydroxy-4-methyl-5-nitropyridine Properties

Melting point 186-190 °C (lit.)
Boiling point 277.46°C (rough estimate)
Density 1.4564 (rough estimate)
refractive index 1.5100 (estimate)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
pka 8.10±0.10(Predicted)
form Crystalline Powder
color Yellow to orange
BRN 136900
InChI 1S/C6H6N2O3/c1-4-2-6(9)7-3-5(4)8(10)11/h2-3H,1H3,(H,7,9)
InChIKey AIEHUZHKFUNHCJ-UHFFFAOYSA-N
SMILES Cc1cc(O)ncc1[N+]([O-])=O
CAS DataBase Reference 21901-41-7(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  26-37/39-36/37/39-36
RIDADR  2811
WGK Germany  3
HazardClass  6.1
PackingGroup  III
HS Code  29337900
Storage Class 11 - Combustible Solids
Hazard Classifications Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

2-Hydroxy-4-methyl-5-nitropyridine price More Price(28)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 290106 2-Hydroxy-4-methyl-5-nitropyridine 98% 21901-41-7 5g $185 2023-01-07 Buy
TCI Chemical H1050 2-Hydroxy-4-methyl-5-nitropyridine >98.0%(GC)(T) 21901-41-7 1g $25 2026-03-19 Buy
TCI Chemical H1050 2-Hydroxy-4-methyl-5-nitropyridine >98.0%(GC)(T) 21901-41-7 5g $78 2026-03-19 Buy
TRC M218915 4-Methyl-5-nitro-1,2-dihydropyridin-2-one 21901-41-7 100mg $75 2021-12-16 Buy
Matrix Scientific 024735 2-Hydroxy-4-methyl-5-nitropyridine 98% 21901-41-7 100g $178 2021-12-16 Buy
Product number Packaging Price Buy
290106 5g $185 Buy
H1050 1g $25 Buy
H1050 5g $78 Buy
M218915 100mg $75 Buy
024735 100g $178 Buy

2-Hydroxy-4-methyl-5-nitropyridine Chemical Properties,Uses,Production

Chemical Properties

Orange plates

Uses

The conformational stability and the vibartional analysis of 2-hydroxy-4-methyl-5-nitropyridine was studied.

General Description

The conformational stability and the vibartional analysis of 2-hydroxy-4-methyl-5-nitropyridine was studied.

Synthesis

2-Amino-5-nitro-4-picoline

21901-40-6

2-Hydroxy-4-methyl-5-nitropyridine

21901-41-7

General procedure for the synthesis of 2-hydroxy-4-methyl-5-nitropyridine from 2-amino-4-methyl-5-nitropyridine: 2-amino-4-methyl-5-nitropyridine (10 g, 23 mmol) was weighed and placed in a 250 ml round-bottomed flask, and 70 ml of concentrated sulphuric acid was added to dissolve it until the raw material was completely dissolved. The reaction flask was placed in a cold bath at a low temperature of -5 °C, and a pre-configured aqueous solution of sodium nitrite (NaNO2, 6.76 g) was slowly added dropwise through a constant pressure dropping funnel. A large number of bubbles were generated during the addition, and the rate of titration needed to be controlled to avoid a rapid increase in temperature and to ensure that the reaction temperature did not exceed 0 °C. The reaction was carried out at a constant pressure. A solid was gradually precipitated during the reaction. After dropwise addition, stirring was continued for 10 minutes, and the reaction solution turned orange and clarified. The reaction was continued at 0 °C and the progress of the reaction was monitored by thin layer chromatography (TLC).The reaction was stopped after 3 hours when the TLC showed that the reaction was complete. The reaction solution was slowly poured into a beaker containing about 300 mL of water and a large amount of yellow solid precipitated. After leaving to crystallize for 3 h at room temperature, the solid was collected by filtration and dried under infrared lamp to give 6.72 g of yellow solid product in 67.2% yield.

References

[1] Patent: CN105906621, 2016, A. Location in patent: Paragraph 0045
[2] Patent: EP2366691, 2011, A1. Location in patent: Page/Page column 13
[3] Journal of the Chemical Society, 1954, p. 2448,2455
[4] Journal of Organic Chemistry, 1955, vol. 20, p. 1729,1731
[5] Patent: WO2007/53394, 2007, A1. Location in patent: Page/Page column 12

2-Hydroxy-4-methyl-5-nitropyridine Preparation Products And Raw materials

Raw materials

2-Amino-5-nitro-4-picoline 2-METHOXY-5-NITRO-4-PICOLINE

Preparation Products

3-AMINO-6-CHLORO-4-PICOLINE 2-Bromo-5-nitro-4-picoline 3-Fluoropyridine-4-carboxylic acid 2-METHOXY-5-NITRO-4-PICOLINE 4-{5-nitro-4-methyl-2-pyridinyl}morpholine

2-Hydroxy-4-methyl-5-nitropyridine Suppliers

Global( 316)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652 info@fdachem.com China 20124 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718; +8613336195806 sales@capot.com China 29640 60
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29822 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10404 58
Alchem Pharmtech,Inc. 		8485655694 sales@alchempharmtech.com United States 63687 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49977 58
Antai Fine Chemical Technology Co.,Limited 		18503026267 info@antaichem.com CHINA 9636 58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		+8613580539051 joe@yuhengpharm.com CHINA 21142 58
Supplier Advantage
Hebei Chuanghai Biotechnology Co., Ltd 		58
Henan Fengda Chemical Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Alchem Pharmtech,Inc. 		58
CONIER CHEM AND PHARMA LIMITED 		58
Antai Fine Chemical Technology Co.,Limited 		58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd 		58

View Lastest Price from 2-Hydroxy-4-methyl-5-nitropyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Hydroxy-4-methyl-5-nitropyridine pictures 2026-03-20 2-Hydroxy-4-methyl-5-nitropyridine
21901-41-7
 US $10.00 / KG 1KG 99% 10 mt Hebei Chuanghai Biotechnology Co., Ltd
2-Hydroxy-4-methyl-5-nitropyridine pictures 2025-12-01 2-Hydroxy-4-methyl-5-nitropyridine
21901-41-7
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Hydroxy-4-methyl-5-nitropyridine pictures 2025-11-18 2-Hydroxy-4-methyl-5-nitropyridine
21901-41-7
 US $1.10 / g 1g 99.00% 100 Tons Min Dideu Industries Group Limited

2-Hydroxy-4-methyl-5-nitropyridine Spectrum

2-Hydroxy-4-methyl-5-nitropyridine(21901-41-7)1HNMR2-Hydroxy-4-methyl-5-nitropyridine(21901-41-7)IR2-Hydroxy-4-methyl-5-nitropyridine(21901-41-7)FT-IR2-Hydroxy-4-methyl-5-nitropyridine(21901-41-7)Raman

21901-41-7(2-Hydroxy-4-methyl-5-nitropyridine)Related Search:

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4-METHYL-5-NITRO-2(1H)-PYRIDINONE 4-METHYL-5-NITRO-2-PYRIDINOL 4-METHYL-5-NITRO-2-PYRIDONE 5-NITRO-4-PICOLIN-2-OL 2-Hydroxy-4-Methyl-5-Nitropyri 2-HYDROXY-5-NITRO-4-METHYL PYRIDINE 2-HYDROXY-5-NITRO-4-PICOLINE 2-HYDROXY-4-METHYL-5-NITROPYRIDINE 2-HYDROXY-5-NITRO-4-PICOLINE (2-HYDROXY-4-METHYL-5-NITROPYRIDINE) 2(1H)-Pyridinone, 4-methyl-5-nitro- 4-Methyl-5-nitro-2-pyridinone 2-Hydroxy-5-nitro-4-picoline 4-Methyl-5-nitro-2-pyridinol 4-Methyl-5-nitro-2(1H)-pyridinone 4-Methyl-5-nitro-2-pyridone 5-Nitro-4-picolin-2-ol 4-Methyl-5-nitropyridin-2(1H)-one 2-Hydroxy-4-Methyl-5-nitropyridine, 97+% 2-HYDROXY-5-NI 4-methyl-5-nitro-1H-pyridin-2-one 2-Hydroxy-4-methyl-5-nitropyridine 95+% 2-Hydroxy-4-methyl-5-nitropyridine> 2-Hydroxy-4-methyl-5-nitropyridine ISO 9001：2015 REACH 4-Methyl-5-nitro-1,2-dihydropyridin-2-one 2-hydro-4-methyl-5-nitro pyridine 2-hydroxy 4-methyl 5-nitro pyridne 21901-41-7 21901-47-7 2101-41-7 Building Blocks Heterocyclic Building Blocks Pyridines C6 Heterocycle-Pyridine series Building Blocks Chemical Synthesis Heterocyclic Building Blocks Pyridines Miscellaneous alcohol| nitro-compound Pyridine C6