ChemicalBook >> CAS DataBase List >>(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide structure

CAS No.: 80751-65-1

Chemical Name:: (+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Synonyms: Cl-apb;Chloro-AP;SK&F 82958;SKF82958 HBr;SKF82958,SKF 82958;6H-Benzo[cd]pyren-7-one;(±)-SKF 82958;CHLORO-APB;(+/-)-SKF-82958 HYDROBROMIDE;(+/-)-Chloro-apbhydrobromide;(+/-)-CHLORO-APB HYDROBROMIDE

CBNumber:: CB3251102

Molecular Formula:: C19H20ClNO2

Molecular Weight:: 329.82

MDL Number:: MFCD00069235

MOL File:: 80751-65-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:51:54

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(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Properties

Boiling point	473.7±45.0 °C(Predicted)
Density	1.234±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H₂O: 3.7 mg/mL
form	solid
pka	8.73±0.40(Predicted)
color	tan
Water Solubility	H2O: 3.7mg/mL aqueous base: unstable ethanol: soluble
InChI	1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H
InChIKey	WLXGFAVTAAQOFH-UHFFFAOYSA-N
SMILES	Br.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3
EWG's Food Scores	1
FDA UNII	7W60FE897Q
UNSPSC Code	12352200
NACRES	NA.77

SAFETY

Risk and Safety Statements

PPE	Eyeshields, Gloves, type N95 (US)
WGK Germany	3
Storage Class	11 - Combustible Solids

(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	C130	Chloro-APB hydrobromide solid	80751-65-1	5mg	$196	2026-04-30	Buy
Sigma-Aldrich	C130	Chloro-APB hydrobromide solid	80751-65-1	25mg	$674	2026-04-30	Buy
Biosynth	FDA75165	Chloro-apb hydrobromide	80751-65-1	25mg	$1138	2026-06-04	Buy
Biosynth	FDA75165	Chloro-apb hydrobromide	80751-65-1	50mg	$1583.5	2026-06-04	Buy
Biosynth	FDA75165	Chloro-apb hydrobromide	80751-65-1	100mg	$2535	2026-06-04	Buy

Product number	Packaging	Price	Buy
C130	5mg	$196	Buy
C130	25mg	$674	Buy
FDA75165	25mg	$1138	Buy
FDA75165	50mg	$1583.5	Buy
FDA75165	100mg	$2535	Buy

(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Chemical Properties, Uses, Production

Uses

Chloro-APB hydrobromide has been used to pharmacologically stimulate D1 dopamine receptors and study its influence on locomotor response in fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice.

Definition

ChEBI: 9-chloro-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol is a benzazepine.

Biochem/physiol Actions

Chloro-APB hydrobromide, also known as SKF 82958, is a D1 dopamine receptor agonist. D1 receptor agonists prevent and reverse fentanyl-induced respiratory depression, without impairing opioid analgesia, in cats.

in vivo

SKF-82958 ((±)-SKF 82958) (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 training dose 0.03 mg/kg. Increasing the dose of SKF-82958 also results in a significant reduction in response rate^[2].
SKF-82958 (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements^[3].

Animal Model:	Male Sprague-Dawley rats^[3]
Dosage:	0.5-2.0 mg/kg
Administration:	I.p
Result:	Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.

(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Preparation Products And Raw materials

Raw materials

Preparation Products

(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Suppliers

Global Suppliers ( 39)

Supplier	Tel	Email	Country	ProdList	Advantage
T&W GROUP	021-61551611 13296011611	contact@trustwe.com	China	9884	58
Shanghai T&W Pharmaceutical Co., Ltd.	+86 21 61551611		China	9874	58
SynAsst Chemical.	021-60343070		China	12731	55
Finetech Industry Limited	027-87465837 19945049750	sales@finetechnology-ind.com	China	9331	58
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51389	80
Birdo (Shanghai) Medical Technology Co., Ltd.	021-58099077	sales@birdochem.com	China	185	55
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Musechem	+1-800-259-7612	info@musechem.com	United States	4648	60
Finetech Industry Limited	+86-27-8746-5837 +86-18627785180	info@finetechnology-ind.com	China	9533	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58

Supplier	Advantage
T&W GROUP	58
Shanghai T&W Pharmaceutical Co., Ltd.	58
SynAsst Chemical.	55
Finetech Industry Limited	58
Sigma-Aldrich	80
Birdo (Shanghai) Medical Technology Co., Ltd.	55
Amadis Chemical Company Limited	58
Musechem	60
Finetech Industry Limited	58
TargetMol Chemicals Inc.	58

View Latest Price from (+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-05-11	SKF-82958 80751-65-1	$1520.00-2500.00			10g	TargetMol Chemicals Inc.

SKF-82958
80751-65-1
$1520.00-2500.00
TargetMol Chemicals Inc.

80751-65-1 ((+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide) Related Search:

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Dopamine 2-(3-Chlorophenyl)ethylamine 2,3,4,5-Tetrahydro-1H-benzo[d]azepin-7-ol (+/-)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

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N-Isobutyl-2-propen-1-amine [2-(3-Chloro-phenyl)-ethyl]-ethyl-amine (+/-)-7,8-Dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

1of4

(±)-SKF 82958;CHLORO-APB (+/-)-SKF-82958 HYDROBROMIDE 6-CHLORO-N-ALLYL-SKF-38393 HYDROBROMIDE SK&F 82958 (±)-SKF-82958 hydrobromide, 6-Chloro-N-allyl-SKF-38393 hydrobromide, (±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide 6-Chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)- 6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine Cl-apb SKF82958 HBr 3-allyl-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol (+/-)-CHLORO-APB HYDROBROMIDE (+/-)-CHLORO-APB HYDROBROMIDE ((+/-)-SKF -82958 HBR) 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)- (+/-)-Chloro-apbhydrobromide Chloro-AP 6H-Benzo[cd]pyren-7-one SKF82958,SKF 82958 (+/-)-6-CHLORO-7,8-DIHYDROXY-3-ALLYL-1-P... (+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide 80751-65-1 C19H20ClNO2HBr