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(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

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(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide manufacturers

  • SKF-82958
  • SKF-82958 pictures
  • $1980.00
  • 2026-05-11
  • CAS:80751-65-1
  • Purity:
  • Supply Ability: 10g
(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Basic information
Product Name:(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
Synonyms:(±)-SKF 82958;CHLORO-APB;(+/-)-SKF-82958 HYDROBROMIDE;6-CHLORO-N-ALLYL-SKF-38393 HYDROBROMIDE;SK&F 82958;(±)-SKF-82958 hydrobromide, 6-Chloro-N-allyl-SKF-38393 hydrobromide, (±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide;6-Chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol;1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-;6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
CAS:80751-65-1
MF:C19H20ClNO2
MW:329.82
EINECS:
Product Categories:
Mol File:80751-65-1.mol
(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Structure
(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Chemical Properties
Boiling point 473.7±45.0 °C(Predicted)
density 1.234±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility H2O: 3.7 mg/mL
form solid
pka8.73±0.40(Predicted)
color tan
Water Solubility H2O: 3.7mg/mL
aqueous base: unstable
ethanol: soluble
InChI1S/C19H20ClNO2.BrH/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13;/h2-7,11,16,22-23H,1,8-10,12H2;1H
InChIKeyWLXGFAVTAAQOFH-UHFFFAOYSA-N
SMILESBr.Oc1cc2C(CN(CCc2c(Cl)c1O)CC=C)c3ccccc3
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
ProviderLanguage
SigmaAldrich English
(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Usage And Synthesis
UsesChloro-APB hydrobromide has been used to pharmacologically stimulate D1 dopamine receptors and study its influence on locomotor response in fat mass and obesity-associated protein (FTO) deficient dopamine D1 receptor-expressing medium spiny neurons (D1 MSNs) of mice.
DefinitionChEBI: 9-chloro-5-phenyl-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol is a benzazepine.
Biochem/physiol ActionsChloro-APB hydrobromide, also known as SKF 82958, is a D1 dopamine receptor agonist. D1 receptor agonists prevent and reverse fentanyl-induced respiratory depression, without impairing opioid analgesia, in cats.
in vivo

SKF-82958 ((±)-SKF 82958) (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 training dose 0.03 mg/kg. Increasing the dose of SKF-82958 also results in a significant reduction in response rate[2].
SKF-82958 (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3].

Animal Model:Male Sprague-Dawley rats[3]
Dosage:0.5-2.0 mg/kg
Administration:I.p
Result:Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide Preparation Products And Raw materials
Tag:(+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide(80751-65-1) Related Product Information
N,N-BIS(2-PHENYL-ETHYL)-N-METHYL-AMINE Hordenine hydrochloride Dopamine 3-CHLORO-5-METHYLPHENOL 3-CHLORO-4-METHYLPHENOL 2-(3-Chlorophenyl)ethylamine 3-CHLOROCATECHOL ethyl(1-phenylethyl)benzene 6-CHLORO-2,3,4,5-TETRAHYDRO-1-(3-METHYLPHENYL)-3-(2-PROPENYL)-1H-3-BENZAZEPINE-7,8-DIOL HYDROBROMIDE [2-(3-CHLORO-PHENYL)-ETHYL]-METHYL-AMINE N,beta-Dimethylphenethylamine hydrochloride 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPINE (+/-)-6-Chloro-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (+/-)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide 2,3,4,5-TETRAHYDRO-1H-BENZO[D]AZEPIN-7-OL 2-phenyl-4-azabicyclo[5.4.0]undeca-7,9,11-triene-9,10-diol (+/-)-7,8-Dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide [2-(3-Chloro-phenyl)-ethyl]-ethyl-amine