Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>4-Cyano-2-methoxypyridine

4-Cyano-2-methoxypyridine

4-Cyano-2-methoxypyridine Structure
4-Cyano-2-methoxypyridine structure
CAS No.
72716-86-0
Chemical Name:
4-Cyano-2-methoxypyridine
Synonyms
2-METHOXYISONICOTINONITRILE;4-Cyano-2-methoxypyridine;4-Cyano-2-methoxypyridine 98%;2-Methoxyisonicotinonitrile 98%;2-Methoxy-4-Pyridinecarbonitrile;4-Pyridinecarbonitrile, 2-methoxy-;2-cyano-2-Methoxy-1,2-dihydropyridine-4-carboxylic acid
CBNumber:
CB3308231
Molecular Formula:
C7H6N2O
Molecular Weight:
134.14
MDL Number:
MFCD06659893
MOL File:
72716-86-0.mol
MSDS File:
SDS
Last updated:2026-09-12 18:51:59
Request For Quotation

4-Cyano-2-methoxypyridine Properties

Melting point 88-92
Boiling point 207.1±25.0 °C(Predicted)
Density 1.16±0.1 g/cm3(Predicted)
storage temp. Inert atmosphere,Room Temperature
form solid
pka 0.04±0.10(Predicted)
color White

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P280-P305+P351+P338-P310
Hazard Codes  Xi
Hazard Note  Irritant
HS Code  2933399990

4-Cyano-2-methoxypyridine price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
AstaTech 30042 2-METHOXYISONICOTINONITRILE 97% 72716-86-0 5G $43 2026-04-30 Buy
Activate Scientific AS143821 2-Methoxyisonicotinonitrile 98% 72716-86-0 1g $27 2026-06-04 Buy
Activate Scientific AS143821 2-Methoxyisonicotinonitrile 98% 72716-86-0 5g $85 2026-06-04 Buy
Activate Scientific AS143821 2-Methoxyisonicotinonitrile 98% 72716-86-0 25g $277 2026-06-04 Buy
Activate Scientific AS143821 2-Methoxyisonicotinonitrile 98% 72716-86-0 100g $693 2026-06-04 Buy
Product number Packaging Price Buy
30042 5G $43 Buy
AS143821 1g $27 Buy
AS143821 5g $85 Buy
AS143821 25g $277 Buy
AS143821 100g $693 Buy

4-Cyano-2-methoxypyridine Chemical Properties,Uses,Production

Uses

4-Cyano-2-methoxypyridine is a reagent used in the synthesis of hydroxypyridone derivatives which are bioisosters of capsain.

Synthesis

2-Chloro-4-cyanopyridine

33252-30-1

Sodium Methoxide

124-41-4

4-CYANO-2-METHOXYPYRIDINE

72716-86-0

General procedure for the synthesis of 4-cyano-2-methoxypyridine from 2-chloro-4-cyanopyridine and sodium methanol: To a solution of 2-chloro-4-cyanopyridine (1.38 g, 10 mmol) in dioxane (10 mL) was added a methanolic solution of sodium methanol (25%, 2.27 g, 10.5 mmol). The reaction mixture was heated to reflux for 5 h, followed by cooling to room temperature and standing overnight in a refrigerator. The precipitate was collected by filtration and washed with methanol. The filtrate was concentrated to about 10 mL and water (100 mL) was added. The precipitate was collected by filtration again and washed with water to give 4-cyano-2-methoxypyridine (1.93 g, 72% yield) as a white solid. Mass spectrum (electrospray positive ion mode) m/z 135 [M + H]+.

References

[1] Journal of Medicinal Chemistry, 2008, vol. 51, # 21, p. 6631 - 6634
[2] Patent: WO2006/9889, 2006, A1. Location in patent: Page/Page column 54
[3] Patent: WO2006/33011, 2006, A1. Location in patent: Page/Page column 28
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 7, p. 2669 - 2684
[5] European Journal of Medicinal Chemistry, 1993, vol. 28, # 7-8, p. 601 - 608

4-Cyano-2-methoxypyridine synthesis

33252-30-1
72716-86-0
Synthesis of 4-Cyano-2-methoxypyridine from 2-Chloro-4-cyanopyridine

4-Cyano-2-methoxypyridine Preparation Products And Raw materials

Raw materials

4-Amino-2-methoxypyridine 2-Chloro-4-cyanopyridine POTASSIUM CYANIDE Methanol Lithium methoxide
Sodium Methoxide

1of2

Preparation Products

2-Methoxy-4-pyridinecarboxylic acid 4-Pyridinemethanamine,2-methoxy-(9CI) tert-butyl N-[(2-oxo-1,2-dihydropyridin-4-yl)methyl]carbamate

4-Cyano-2-methoxypyridine Suppliers

Global( 104)Suppliers
Supplier Tel Email Country ProdList Advantage
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
JinYan Chemicals(ShangHai) Co.,Ltd. 13817811078 sales@jingyan-chemical.com China 9963 60
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Jinan Trio PharmaTech Co., Ltd. 0531-88811783 sales@trio-pharmatech.com China 1856 62
Chiba Pharmaceutical Science and technology Co, Ltd. 0531-81313138 13066006660 chibapharm@foxmail.com China 3996 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66113011 13913916777 cfzhang@aikonchem.com China 19902 55
9ding chemical ( Shanghai) Limited 4009209199 sales@9dingchem.com China 18201 56
Shanghai Raise Chemical Technology Co.,Ltd +86-021-50935922 China 7854 55
Supplier Advantage
J & K SCIENTIFIC LTD. 76
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
JinYan Chemicals(ShangHai) Co.,Ltd. 60
Adamas Reagent, Ltd. 59
Jinan Trio PharmaTech Co., Ltd. 62
Chiba Pharmaceutical Science and technology Co, Ltd. 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 55
9ding chemical ( Shanghai) Limited 56
Shanghai Raise Chemical Technology Co.,Ltd 55

View Lastest Price from 4-Cyano-2-methoxypyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-CYANO-2-METHOXYPYRIDINE pictures 2020-01-13 4-CYANO-2-METHOXYPYRIDINE
72716-86-0
 $1.00 1KG 98%-99.9% 100kg Career Henan Chemical Co

4-Cyano-2-methoxypyridine Spectrum

4-CYANO-2-METHOXYPYRIDINE(72716-86-0)1HNMR

72716-86-0(4-Cyano-2-methoxypyridine)Related Search:

2-Cyano-6-methoxypyridine 2-Amino-3-cyano-4-methoxypyridine 2-Amino-5-bromo-3-cyano-4-methoxypyridine 2-Methoxypyridine 4-Cyano-2-methoxypyridine
2-Methoxypyridine-5-carbonitrile 3-Cyano-2-methoxypyridine 4-Methoxypyridine-2-carbonitrile 3-IODO-2-METHOXYISONICOTINONITRILE 2-Amino-5-bromo-4-methoxypyridine-3-carbonitrile, 2-Amino-5-bromo-3-cyano-4-methoxypyridine
2-CYANO-3-METHOXYPYRIDINE tert-butyl 4-[(4-cyano-2-pyridinyl)oxy]tetrahydro-1(2H)-pyridinecarboxylate 2-(benzyloxy)isonicotinonitrile 3-Cyano-5-methoxypyridine 2-METHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)NICOTINONITRILE
2-[4-(cyanomethyl)phenoxy]isonicotinonitrile 2-(2H-1,3-benzodioxol-5-yloxy)pyridine-4-carbonitrile 2-HYDROXY-3-CYANO-4-METHOXYPYRIDINE

1of4

4-Cyano-2-methoxypyridine 98% 2-cyano-2-Methoxy-1,2-dihydropyridine-4-carboxylic acid 2-Methoxy-4-Pyridinecarbonitrile 4-Pyridinecarbonitrile, 2-methoxy- 2-Methoxyisonicotinonitrile 98% 2-METHOXYISONICOTINONITRILE 4-Cyano-2-methoxypyridine 72716-86-0 blocks Carboxes Pyridines