ChemicalBook >> CAS DataBase List >>3-BROMO-4-FORMYLPYRIDINE

3-BROMO-4-FORMYLPYRIDINE

CAS No.
70201-43-3
Chemical Name:
3-BROMO-4-FORMYLPYRIDINE
Synonyms
3-BROMOISONICOTINALDEHYDE;CHEMBRDG-BB 4003258;3-BROMO-4-FORMYLPYRIDI;3-BROMO-4-FORMYLPYRIDINE;3-Bromoisonicotinaldehyde 95%;3-Bromo-4-pyridinecarbaldehyde;3-Bromoisonicotinaldehyde ,98%;3-BROMO-PYRIDINE-4-CARBALDEHYDE;3-BROMO-4-PYRIDINECARBOXALDEHYDE;5-BroMopyridine-4-carboxaldehyde
CBNumber:
CB3351242
Molecular Formula:
C6H4BrNO
Molecular Weight:
186.01
MDL Number:
MFCD05864506
MOL File:
70201-43-3.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-20 23:19:27
Product description Number Pack Size Price
3-Bromo-4-pyridinecarboxaldehyde 97% 638285 5g $222
3-Bromo-4-pyridinecarboxaldehyde 97% 638285 1g $77.8
3-Bromopyridine-4-carboxaldehyde B2624 1G $32
3-Bromopyridine-4-carboxaldehyde B2624 5G $126
3-Bromo-4-pyridinecarboxaldehyde Asreported 264417 1g $408
More product size

3-BROMO-4-FORMYLPYRIDINE Properties

Melting point 81-82 °C(lit.)
Boiling point 246.2±20.0 °C(Predicted)
Density 1.683±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility Acetonitrile (Slightly), Chloroform (Slightly)
form Solid
pka 0.90±0.18(Predicted)
color Light Brown
InChI 1S/C6H4BrNO/c7-6-3-8-2-1-5(6)4-9/h1-4H
InChIKey NOBDKWLIAQKADB-UHFFFAOYSA-N
SMILES [H]C(=O)c1ccncc1Br
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H317-H319
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338
PPE dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes  Xn,Xi
Risk Statements  22-36/38-43
Safety Statements  26-36/37
WGK Germany  3
Hazard Note  Irritant
HS Code  29333990
Storage Class 11 - Combustible Solids
Hazard Classifications Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
Skin Sens. 1
NFPA 704
0
2 0

3-BROMO-4-FORMYLPYRIDINE price More Price(103)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 638285 3-Bromo-4-pyridinecarboxaldehyde 97% 70201-43-3 5g $222 2026-04-30 Buy
Sigma-Aldrich 638285 3-Bromo-4-pyridinecarboxaldehyde 97% 70201-43-3 1g $77.8 2023-01-07 Buy
TCI Chemical B2624 3-Bromopyridine-4-carboxaldehyde 70201-43-3 1G $32 2026-04-30 Buy
TCI Chemical B2624 3-Bromopyridine-4-carboxaldehyde 70201-43-3 5G $126 2026-04-30 Buy
Usbiological 264417 3-Bromo-4-pyridinecarboxaldehyde Asreported 70201-43-3 1g $408 2026-06-03 Buy
Product number Packaging Price Buy
638285 5g $222 Buy
638285 1g $77.8 Buy
B2624 1G $32 Buy
B2624 5G $126 Buy
264417 1g $408 Buy

3-BROMO-4-FORMYLPYRIDINE Chemical Properties,Uses,Production

Chemical Properties

Off-white solid

Uses

3-Bromo-4-pyridinecarboxaldehyde acts as a reagent in the synthesis of 3,4,5-trisubstituted 4,5-dihydro-1,2,4-oxadiazoles agonists which interact with the G-protein-coupled bile acid receptor 1 (TGR5) inducing insulin secretion which may be used as a potential treatment for diabetus mellitus.

Synthesis

3-Pyridyl bromide

626-55-1

N,N-Dimethylformamide

68-12-2

3-BROMO-4-FORMYLPYRIDINE

70201-43-3

Diisopropylamine (27.6 g, 273.0 mmol) was dissolved in tetrahydrofuran (300 mL) under nitrogen protection and cooled to -78 °C. A tetrahydrofuran solution of n-butyllithium (91 mL, 228.0 mmol, 2.5 M) was slowly added dropwise and stirred at -78 °C for 1 hour. Subsequently, 3-bromopyridine (30.0 g, 190.0 mmol) was added dropwise and stirring was continued at -78 °C for 20 min. Next, N,N-dimethylformamide (55.0 g, 760.0 mmol) was added dropwise and stirred at -78 °C for 1 hour. After completion of the reaction, the mixture was slowly warmed to room temperature and the reaction was quenched with saturated aqueous ammonium chloride solution (150 mL). The aqueous layer was extracted with ethyl acetate (200 mL x 3), and the organic layers were combined and concentrated in vacuum. The residue was purified by silica gel column chromatography to afford 3-bromopyridine-4-aldehyde (12.0 g, 34.0% yield). The product was confirmed by 1H NMR (400 MHz, CD3OD): δ 10.37 (s, 1H), 8.91 (s, 1H), 8.80-8.61 (m, 1H), 7.78-7.63 (m, 1H).LCMS (m/z): 187.0 (M + 1).

References

[1] Tetrahedron, 2000, vol. 56, # 3, p. 397 - 406
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 11, p. 3146 - 3151
[3] Patent: WO2015/200677, 2015, A2. Location in patent: Paragraph 00504; 00505
[4] Tetrahedron Letters, 1983, vol. 24, # 32, p. 3291 - 3294
[5] Synthesis, 1999, # 2, p. 306 - 311

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View Lastest Price from 3-BROMO-4-FORMYLPYRIDINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-BROMO-4-FORMYLPYRIDINE pictures 2026-07-21 3-BROMO-4-FORMYLPYRIDINE
70201-43-3
1kg 98% 1000kgs Shaanxi Dideu New Materials Co. Ltd
3-BROMO-4-FORMYLPYRIDINE pictures 2025-11-18 3-BROMO-4-FORMYLPYRIDINE
70201-43-3
$1.10 1g 99.00% 100 Tons min Dideu Industries Group Limited
3-Bromopyridine-4-carboxaldehyde pictures 2020-05-13 3-Bromopyridine-4-carboxaldehyde
70201-43-3
1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd

3-BROMO-4-FORMYLPYRIDINE Spectrum

3-Bromoisonicotinaldehyde ,98% 3-Bromopyridine-4-carboxaldehyde ,98% 3-Bromoisonicotinaldehyde 95% 5-BroMopyridine-4-carboxaldehyde CHEMBRDG-BB 4003258 3-BROMO-4-PYRIDINECARBOXALDEHYDE 3-BROMO-4-FORMYLPYRIDINE 3-BROMO-PYRIDINE-4-CARBALDEHYDE 3-BROMOPYRIDINE-4-CARBOXALDEHYDE 3-Bromopyridine-4-carboxaldehyde 95% 3-Bromo-4-pyridinecarbaldehyde 4-Pyridinecarboxaldehyde, 3-bromo- 3-BROMO-4-FORMYLPYRIDINE ISO 9001:2015 REACH 3-BROMO-4-FORMYLPYRIDI 3-BROMOISONICOTINALDEHYDE 70201-43-3 70201-43-2 Pyridines Heterocyclic Building Blocks Halogenated Heterocycles Building Blocks C1 to C6 C5 to C6 C6 to C7 Carbonyl Compounds Chemical Synthesis Halogenated Heterocycles Heterocyclic Building Blocks pharmacetical Aldehydes Pyridines Pyridine Building Blocks Halogenated C6Heterocyclic Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks Organic Building Blocks