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2-Bromo-3-formylpyridine

2-Bromo-3-formylpyridine structure

CAS No.: 128071-75-0

Chemical Name:: 2-Bromo-3-formylpyridine

Synonyms: 2-BROMONICOTINALDEHYDE;CAS:128071-75-0;2-Bromopyridine-3-ca;2-Bromo-3-formylpyridine;2-Bromonicotinaldehyde 97%;2-Bromonicotinaldehyde >2-broMopyridin-3-carbaldehyde;-Bromopyridine-3-carbaldehyde;2-bromopyridine-3-formaldehyde;2-Bromo-3-pyridinecarbaldehyde

CBNumber:: CB3710744

Molecular Formula:: C6H4BrNO

Molecular Weight:: 186.01

MDL Number:: MFCD04966945

MOL File:: 128071-75-0.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:52:10

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2-Bromo-3-formylpyridine Properties

Melting point	73 °C
Boiling point	100 °C / 3mmHg
Density	1.683±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	powder to crystal
pka	-1.01±0.10(Predicted)
color	White to Orange to Green
InChI	InChI=1S/C6H4BrNO/c7-6-5(4-9)2-1-3-8-6/h1-4H
InChIKey	GNFWMEFWZWXLIN-UHFFFAOYSA-N
SMILES	C1(Br)=NC=CC=C1C=O
CAS DataBase Reference	128071-75-0(CAS DataBase Reference)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H317-H319

Precautionary statements

P280-P301+P312+P330-P302+P352-P305+P351+P338

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Xn,Xi

Risk Statements

22-36-43

Safety Statements

26-36/37

WGK Germany

Hazard Note

Irritant

HS Code

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
Skin Sens. 1

NFPA 704

	0
2		0

2-Bromo-3-formylpyridine price More Price(88)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	632147	2-Bromo-3-pyridinecarboxaldehyde 96%	128071-75-0	1g	$28.5	2026-04-30	Buy
Sigma-Aldrich	632147	2-Bromo-3-pyridinecarboxaldehyde 96%	128071-75-0	5g	$50.3	2026-04-30	Buy
TCI Chemical	B2625	2-Bromonicotinaldehyde >98.0%(GC)	128071-75-0	1g	$32	2026-04-30	Buy
TCI Chemical	B2625	2-Bromonicotinaldehyde >98.0%(GC)	128071-75-0	5g	$106	2026-04-30	Buy
Usbiological	264453	2-Bromopyridine-3-carbaldehyde Asreported	128071-75-0	2g	$319	2026-06-03	Buy

Product number	Packaging	Price	Buy
632147	1g	$28.5	Buy
632147	5g	$50.3	Buy
B2625	1g	$32	Buy
B2625	5g	$106	Buy
264453	2g	$319	Buy

2-Bromo-3-formylpyridine Chemical Properties, Uses, Production

Uses

2-Bromo-3-pyridinecarboxaldehyde is a pyridine heterocyclic compound mainly used in laboratory organic synthesis processes.

Chemical Properties

Yellow solid

Uses

It is well known that many heterocyclic compounds play an important role as a basic unit for drug design. 2-Bromopyridine-3-carbaldehyde may undergo palladium-catalyzed carbonylative cyclization with carboxylic acids to synthesize furo[3,4-b]pyridine derivatives, which are bioactive phthalide analogs.^[6]

Synthesis

109-04-6

68-12-2

128071-75-0

To a cooled solution of diisopropylamine (20.4 g, 28.0 mL, 0.202 mol) in anhydrous THF (400 mL) at -78 °C was slowly added n-BuLi (0.192 mol, 58.0 mL, 3.3 M hexane solution). The reaction mixture was stirred at -78 °C for 1 h, followed by the dropwise addition of anhydrous THF (150 mL) solution of 2-bromopyridine (25.3 g, 0.160 mol) over 20 min. After keeping the reaction at -78 °C for 90 min, an anhydrous THF (25 mL) solution of DMF (35.0 g, 0.480 mol) cooled to -78 °C was quickly added. Stirring was continued at -78 °C for 80 min, and upon completion of the reaction, the reaction was quenched with NaH2PO4 (27.6 g, 0.230 mol, dissolved in H2O (120 mL)), slowly warmed to room temperature, and diluted with MeOt-Bu (500 mL). The organic phase was separated, washed with brine (2100 mL), dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude product was ground with pentane and after decantation, the remaining solid was recrystallized from hexane to give 16.7 g of 2-bromo-3-pyridinecarboxaldehyde as a pale yellow solid in 56% yield, melting point 67-69 °C. 1H NMR (400 MHz, CDCl3) δ: 10.35 (s, 1H), 8.57 (dd, J=4.7,2.1 Hz, 1H), 8.17 (dd, J= 7.6,2.1Hz, 1H), 7.44 (dd, J=7.6,4.7,0.6Hz, 1H).13C NMR (101MHz, CDCl3) δ: 190.4,154.0,144.9,137.5,130.1,123.0. Calculated values for elemental analyses (C6H4BrNO): C, 38.74; H. 2.17; N, 7.53; Br, 42.96. Measured values: C, 38.58; H, 2.08; N, 7.57; Br, 42.69.

References

[1] Tetrahedron Letters, 2008, vol. 49, # 17, p. 2839 - 2843
[2] Chemical Communications, 2011, vol. 47, # 23, p. 6635 - 6637
[3] Organic Letters, 2007, vol. 9, # 5, p. 891 - 894
[4] Tetrahedron Letters, 2017, vol. 58, # 20, p. 1989 - 1991
[5] Synthesis (Germany), 2018, vol. 50, # 1, p. 155 - 169
[1] Journal of Heterocyclic Chemistry, 2009, 45 5: 1397-1399. DOI:10.1002/jhet.5570450523.

2-Bromo-3-formylpyridine Preparation Products And Raw materials

Raw materials

N,N-Dimethylformamide 2-Bromopyridine Sodium borohydride Tetrahydrofuran Ammonium chloride

Isopropylamine n-Butyllithium 2-bromo-3-dibromomethyl-pyridine Ethyl formate Hexane

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Preparation Products

Methyl (2E)-3-(2-bromopyridin-3-yl)prop-2-enoate 2-(4-Fluorophenyl)nicotinaldehyde 2-Pyridinecarboxylic acid, 3-forMyl-, ethyl ester Pyridine, 2-bromo-3-(1,3-dioxolan-2-yl)-

2-Bromo-3-formylpyridine Suppliers

Global Suppliers ( 276)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Raise Pharmatech Co., Ltd.	025-58649566 15005191108	sales@njboyuanchem.com	China	113	60
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
Beijing Ouhe Technology Co., Ltd	13552068683 13522913783	2355560935@qq.com	China	11777	60
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Jia Xing Isenchem Co.,Ltd	0573-85285100 18627885956	isenchem@163.com	China	9389	66

Supplier	Advantage
Nanjing Raise Pharmatech Co., Ltd.	60
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
TCI (Shanghai) Development Co., Ltd.	81
Energy Chemical	61
Capot Chemical Co., Ltd	66
Beijing Ouhe Technology Co., Ltd	60
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Jia Xing Isenchem Co.,Ltd	66

View Latest Price from 2-Bromo-3-formylpyridine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-02	2-BROMO-3-FORMYLPYRIDINE 128071-75-0	$5.00	1KG	98%		Henan Fengda Chemical Co., Ltd
2026-08-20	2-BROMO-3-FORMYLPYRIDINE 128071-75-0	$1.10	1g	99.00%	100 Tons Min	Dideu Industries Group Limited
2026-06-30	2-BROMO-3-FORMYLPYRIDINE 128071-75-0		1KG	98.0%	10000KGS	Shaanxi Dideu New Materials Co. Ltd

2-BROMO-3-FORMYLPYRIDINE
128071-75-0
$5.00
98%
Henan Fengda Chemical Co., Ltd

2-BROMO-3-FORMYLPYRIDINE
128071-75-0
$1.10
99.00%
Dideu Industries Group Limited

2-BROMO-3-FORMYLPYRIDINE
128071-75-0
98.0%
Shaanxi Dideu New Materials Co. Ltd

2-Bromo-3-formylpyridine Spectrum

2-BROMO-3-FORMYLPYRIDINE(128071-75-0)¹HNMR

128071-75-0 (2-Bromo-3-formylpyridine) Related Search:

5-Bromo-3-pyridinecarboxaldehyde ,5-Dihydro-5-methyl-6-[4-(4-oxo-1(4H)-pyridinyl)phenyl]-1,2,4-triazin-3(2H)-one 2-BROMO-4-FORMYLPYRIDINE 6-BROMO-2-FORMYLPYRIDINE,2-BROMO-6-FORMYLPYRIDINE 3,5-Dibromopyridine-4-carboxaldehyde

2-Bromo-5-chloronicotinic acid 2-Bromonicotinic acid 3-Acetyl-2-bromopyridine 2-Bromo-3-formylpyridine 2-Bromopyridine-5-carbaldehyde

5-Bromopyridine-2-carbaldehyde 2-Bromonicotinic acid ethyl ester 2-Bromo-6-trufluoromethyl-3-pyridinecarboxylic acid 2,5-Dibromonicotinic acid 3-Bromo-4-formylpyridine

2-Bromo-5-nitronicotinic acid 2,5-Dibromonicotinaldehyde 2-Bromonicotinamide

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2-BROMO-PYRIDINE-3-CARBALDEHYDE 2-BROMOPYRIDINE-3-CARBOXALDEHYDE 2-BROMO-3-PYRIDINECARBOXALDEHYDE 2-Bromo-3-pyridinecarboxaldehyde ,96% 2-Bromopyridine-3-carboxaldehyde 97% 2-Bromopyridine-3-carboxaldehyde, 2-Bromo-3-formylpyridine 2-Bromo-3-pyridinecarboxaldehyde,2-Bromo-3-formylpyridine 2-Bromonicotinaldehyde 97% 2-bromonicotinaldehyde(SALTDATA: FREE) 2-broMopyridin-3-carbaldehyde 2-Bromo-3-pyridinecarboxaldehyde 96% 2-Bromopyridine-3-ca 2-Bromonicotinaldehyde > 3-Pyridinecarboxaldehyde, 2-bromo- 2-BROMO-3-FORMYLPYRIDINE ISO 9001：2015 REACH -Bromopyridine-3-carbaldehyde 2-bromopyridine-3-formaldehyde 2-Bromo-3-pyridinecarbaldehyde CAS:128071-75-0 2-BROMONICOTINALDEHYDE 2-Bromo-3-formylpyridine 128071-75-0 Halogenated Heterocycles Bromopyridines Halopyridines Pyridines Heterocyclic Building Blocks Building Blocks Heterocycle-Pyridine series Heterocycles Halogenated Organohalides Bromopyridines Halopyridines pharmacetical Aldehydes Pyridines Pyridine Pyridines derivates