TYRPHOSTIN AG 126
- CAS No.
- 118409-62-4
- Chemical Name:
- TYRPHOSTIN AG 126
- Synonyms
- ag127;AG 126;A -126;TYRPHOSTIN A10;Tyrphostin 126;TYRPHOSTIN AG 126;RARECHEM AL BX 0673;AG126, 10 mM in DMSO;AG 126; AG126; AG-126;TYRPHOSTIN AG 126 USP/EP/BP
- CBNumber:
- CB3407273
- Molecular Formula:
- C10H5N3O3
- Molecular Weight:
- 215.16
- MDL Number:
- MFCD00236448
- MOL File:
- 118409-62-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
|---|---|
| solubility | ≤0.15mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide |
| form | Yellow solid |
| color | Light yellow to yellow |
| Sensitive | Light Sensitive |
| InChI | 1S/C10H5N3O3/c11-5-8(6-12)3-7-1-2-9(13(15)16)10(14)4-7/h1-4,14H |
| InChIKey | DUQADSPERJRQBW-UHFFFAOYSA-N |
| SMILES | [N+](=O)([O-])c1c(cc(cc1)C=C(C#N)C#N)O |
| FDA UNII | 7YA4AMD1JC |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H312-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 23/24/25 | |||||||||
| Safety Statements | 26-36-45 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2926907090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
TYRPHOSTIN AG 126 price More Price(49)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 658452 | AG 126 | 118409-62-4 | 5mg | $175 | 2026-04-30 | Buy |
| TCI Chemical | A3345 | AG-126 min. 98.0 % | 118409-62-4 | 5MG | $79 | 2026-04-30 | Buy |
| TCI Chemical | A3345 | AG-126 min. 98.0 % | 118409-62-4 | 25MG | $238 | 2026-04-30 | Buy |
| Cayman Chemical | 13297 | AG-126 ≥95% | 118409-62-4 | 1mg | $31 | 2026-04-30 | Buy |
| Cayman Chemical | 13297 | AG-126 ≥95% | 118409-62-4 | 5mg | $93 | 2026-04-30 | Buy |
TYRPHOSTIN AG 126 Chemical Properties, Uses, Production
Uses
AG126 is a tyrosine kinase inhibitor, can inhibit the phosphorylation of ERK1 and ERK2 at 25-50 μM. AG126 can be used in meiosis, mitosis, and postmitotic research[1][2][3][4].
Definition
ChEBI: 2-[(3-hydroxy-4-nitrophenyl)methylidene]propanedinitrile is a nitrophenol.
Biological Activity
ag-126 is an erk1 and erk2 inhibitor.extracellular signal-regulated kinases (erks) are widely expressed intracellular signalling molecules that are involved in functions including the regulation of meiosis, mitosis, and postmitotic functions. many different stimuli, such as growth factors, cytokines, transforming agents, and carcinogens, can activate the erk pathway.
in vitro
previous study found that r ag126 ould potently inhibit the pcw-evoked release and this effect was rather selective with respect to the stimulus. ag126 was found to be less potent in attenuating lps-triggered release. moreover, it was found that ag126 was able to prevent the pcw-inducible erk phosphorylation, which could relate to the ag126-mediated inhibition of pcw-evoked cytokine release [1].
in vivo
ag126 was tested in a model of pcw-induced meningitis, in which rats underwent intracisternal injection of pcw with and without ag126 pretreatment. pcw injection led to a dramatic leukocyte influx into the csf. ag126 treatment could significantly attenuate such invasion, without changing the number of circulating leukocytes. in addition, ag126 treatment showed beneficial effects on other parameters, such as intracranial pressure. furthermore, ag126 had no adverse effect on several physiological parameters including mean arterial blood pressure, arterial pao2, paco2 as well as ph [1].
IC 50
inhibits the phosphorylation of erk1 and erk2 at 25-50 μm
References
[1] hanisch, u. k.,prinz, m.,angstwurm, k., et al. the protein tyrosine kinase inhibitor ag126 prevents the massive microglial cytokine induction by pneumococcal cell walls. european journal of immunology 31, 2104-2115 (2001).
TYRPHOSTIN AG 126 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Spectrum Chemical Manufacturing Corp. | 021-021-021-67601398-809-809-809 15221380277 | marketing_china@spectrumchemical.com | China | 9643 | 60 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
| Nanjing Dulai Biotechnology Co., Ltd. | 025-84699383-8003;025-846993838003-8003 18013301590 | njduly@126.com | China | 3293 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9792 | 55 |
| ShangHai Biochempartner Co.,Ltd | 177-54423994 17754423994 | 2853530910@QQ.com | China | 8000 | 62 |
View Latest Price from TYRPHOSTIN AG 126 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | AG126
118409-62-4
|
$40.00-140.00 | 98.72% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-12-25 | TYRPHOSTIN AG 126
118409-62-4
|
$1.00 | 1g | 99.99% | 200kg | Career Henan Chemical Co |
-
- AG126
118409-62-4
- $40.00-140.00
- 98.72%
- TargetMol Chemicals Inc.
-
- TYRPHOSTIN AG 126
118409-62-4
- $1.00
- 99.99%
- Career Henan Chemical Co
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