1-Benzofuran-5-carbaldehyde
- CAS No.
- 10035-16-2
- Chemical Name:
- 1-Benzofuran-5-carbaldehyde
- Synonyms
- Benzofuran-5-carbaldehyde;5-Formylbenzofuran;5-Formyl-1-benzofuran;5-FORMYLBENZO(B)FURAN;Benzofurancarbaldehyde;5-Benzofurancarbaldehyde;5-FORMYLBENZO[BETA]FURAN;5-Benzofurancarboxaldehyde;Benzofuran-5-carboxaldehyde;1-BENZOFURAN-5-CARBALDEHYDE
- CBNumber:
- CB3437146
- Molecular Formula:
- C9H6O2
- Molecular Weight:
- 146.14
- MDL Number:
- MFCD03411182
- MOL File:
- 10035-16-2.mol
- MSDS File:
- SDS
| Melting point | 50.5 |
|---|---|
| Boiling point | 70-74°C 0,15mm |
| Density | 1.238±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | low melting solid |
| color | Light yellow crystalline |
| InChI | InChI=1S/C9H6O2/c10-6-7-1-2-9-8(5-7)3-4-11-9/h1-6H |
| InChIKey | LLLBDLDNTMMZHL-UHFFFAOYSA-N |
| SMILES | O1C2=CC=C(C=O)C=C2C=C1 |
| CAS DataBase Reference | 10035-16-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314-H341-H290 |
| Precautionary statements | P501-P260-P202-P234-P201-P264-P280-P390-P308+P313-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36/37/39-37/39 |
| HazardClass | IRRITANT |
| HS Code | 2932990090 |
1-Benzofuran-5-carbaldehyde price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 24019 | 5-FORMYLBENZOFURAN 95% | 10035-16-2 | 1G | $99 | 2026-04-30 | Buy |
| AstaTech | 24019 | 5-FORMYLBENZOFURAN 95% | 10035-16-2 | 5G | $237 | 2026-04-30 | Buy |
| AstaTech | 24019 | 5-FORMYLBENZOFURAN 95% | 10035-16-2 | 25G | $710 | 2026-04-30 | Buy |
| Biosynth | FB10743 | 1-Benzofuran-5-carbaldehyde | 10035-16-2 | 10g | $687.5 | 2026-06-04 | Buy |
| Biosynth | FB10743 | 1-Benzofuran-5-carbaldehyde | 10035-16-2 | 25g | $962.5 | 2026-06-04 | Buy |
1-Benzofuran-5-carbaldehyde Chemical Properties, Uses, Production
Chemical Properties
Colorless to light yellow liqui
Uses
1-Benzofuran-5-carbaldehyde is a building block used as a reactant in the synthetic preparation of benzofuranyl oxadiazoles as inhibitors of glycogen synthase kinase-3β with good brain permeability. It is also used in the synthesis of pyrroloquinolone PDE5 inhibitors used for clinical studies on erectile dysfunction.
Synthesis
![2,3-Dihydrobenzo[b]furan-5-carbaldehyde](/CAS/GIF/55745-70-5.gif)
55745-70-5
10035-16-2
General procedure for the synthesis of benzofuran-5-carbaldehyde from 2,3-dihydrobenzofuran-5-carbaldehyde: N-bromosuccinimide (NBS, 0.656 g, 3.69 mmol) and azobisisobutyronitrile (AIBN, 8.10 mg, 49.2 μmol) were added to a solution of chlorobenzene (7.3 mL) at room temperature and under argon protection to 2,3-dihydrobenzofuran-5-carbaldehyde (0.364 g, 2.46 mmol) in a solution of chlorobenzene (7.3 mL). The reaction mixture was stirred at 80 °C for 1 h before being cooled to room temperature and diluted with ethyl acetate (EtOAc). The organic layer was washed sequentially with saturated aqueous sodium bicarbonate (NaHCO3) and brine, dried over anhydrous sodium sulfate (Na2SO4) and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (eluent: ethyl acetate/hexane, 3:97) to afford benzofuran-5-carbaldehyde (0.268 g, 1.84 mmol, 75% yield) as a colorless oil. Its 1H-NMR (CDCl3, 400 MHz) data were as follows: δ 6.82 (d, J = 2.0 Hz, 1H, furan-H), 7.54 (d, J = 8.8 Hz, 1H, Ar-H), 7.65 (d, J = 2.0 Hz, 1H, furan-H), 7.79 (d, J = 8.8 Hz, 1H, Ar-H), 8.07 (s 1H, Ar-H), 9.99 (s, 1H, -CHO). The spectral data of the obtained compounds are in agreement with literature reports (van Otterlo et al., 2005).
References
[1] Journal of Medicinal Chemistry, 2009, vol. 52, # 20, p. 6270 - 6286
[2] Phytochemistry, 2013, vol. 96, p. 132 - 147
[3] Patent: US2014/309427, 2014, A1. Location in patent: Paragraph 0074; 0075; 0076; 0077
[4] Patent: WO2018/64135, 2018, A1. Location in patent: Paragraph 0174-0177
1-Benzofuran-5-carbaldehyde Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin YongSheng Biotechnology Co., Ltd. | 022-60987737 13512258274;13820956092 | sales@immortalbio.com | China | 154 | 55 |
| Zhengzhou HQ Material Co., Ltd. | 0371-67759225 13526468238 | sale@hqmat.com | China | 1408 | 58 |
| CHENGDU YINGNUOLING PHARMACEUTICAL TECHNOLOGY CO.,LTD | 17882285575 | 1276966012@qq.com | China | 399 | 58 |
| LinkChem Technology Co., Ltd. | 58950110 13124863828 | sales@linkchem.cn | China | 2993 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| JinYan Chemicals(ShangHai) Co.,Ltd. | 13817811078 | sales@jingyan-chemical.com | China | 9963 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
View Latest Price from 1-Benzofuran-5-carbaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-03-21 | 1-Benzofuran-5-carbaldehyde
10035-16-2
|
1kg | 98.0%min | 100kg | LY Global chemicals co.,ltd . | ||
 |
2019-07-06 | 1-Benzofuran-5-carbaldehyde
10035-16-2
|
$8.00 | 1kg | 99% | 10MT | Career Henan Chemical Co |
-
- 1-Benzofuran-5-carbaldehyde
10035-16-2
- $0.00
- 98.0%min
- LY Global chemicals co.,ltd .
-
- 1-Benzofuran-5-carbaldehyde
10035-16-2
- $8.00
- 99%
- Career Henan Chemical Co
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