NPPB
- CAS No.
- 107254-86-4
- Chemical Name:
- NPPB
- Synonyms
- 5-NITRO-2-(3-PHENYLPROPYLAMINO)BENZOIC ACID;NPPB;ANFB;C13705;Iso-ANP;Compound 144;NPPB, 10 mM in DMSO;NPPB, chloride channel blocker;Gamma-brain natriuretic peptide;Recombinant Human NPPB Protein, His Tag
- CBNumber:
- CB3450426
- Molecular Formula:
- C16H16N2O4
- Molecular Weight:
- 300.31
- MDL Number:
- MFCD00153851
- MOL File:
- 107254-86-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 178-180℃ |
|---|---|
| Boiling point | 523.5±50.0 °C(Predicted) |
| Density | 1.323±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | ethanol: 3 mg/mL |
| form | Yellow solid |
| pka | 2.27±0.22(Predicted) |
| color | Light yellow to yellow |
| InChI | 1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20) |
| InChIKey | WBSMIPAMAXNXFS-UHFFFAOYSA-N |
| SMILES | OC(=O)c1cc(ccc1NCCCc2ccccc2)[N+]([O-])=O |
| FDA UNII | 3A35O9G3YZ |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
NPPB price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N4779 | 5-Nitro-2-(3-phenylpropylamino)benzoic acid ≥98% | 107254-86-4 | 25mg | $157 | 2026-04-30 | Buy |
| Sigma-Aldrich | 484100 | 5-Nitro-2-(3-phenylpropylamino)benzoic Acid | 107254-86-4 | 10mg | $134 | 2025-07-31 | Buy |
| Cayman Chemical | 17292 | NPPB ≥98% | 107254-86-4 | 10mg | $62 | 2026-04-30 | Buy |
| Cayman Chemical | 17292 | NPPB ≥98% | 107254-86-4 | 25mg | $134 | 2026-04-30 | Buy |
| Cayman Chemical | 17292 | NPPB ≥98% | 107254-86-4 | 50mg | $222 | 2026-04-30 | Buy |
NPPB Chemical Properties, Uses, Production
Uses
Biochemical probe primarily as a Cl- channel blocker.
Uses
NPPB is a chloride channel blocker and acts as a GPR35 agonist. It maintains protonophoric activity and has been used to uncouple mitochondrial ATP synthesis in phagocytes.
Definition
ChEBI: 5-Nitro-2-(3-phenylpropylamino)benzoic acid is a nitrobenzoic acid.
Biological Activity
Very potent chloride channel blocker.
Biochem/physiol Actions
Potent chloride channel blocker.
storage
Store at RT
NPPB Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Artis Chemistry (Shanghai) Co. Ltd. | 86-21-60936353 | China | 335 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Uchem Inc. | 15618758386 15618758386 | sales3@myuchem.com | China | 1990 | 55 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
