Fipronil
- CAS No.
- 120068-37-3
- Chemical Name:
- Fipronil
- Synonyms
- Termidor;Fipronil 95%;ipronil;Frontline Spot-on;Fluocyanobenpyrazole;5-Amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile;REGENT;PRINCE;FIPRONIL;m&b46030
- CBNumber:
- CB7461570
- Molecular Formula:
- C12H4Cl2F6N4OS
- Molecular Weight:
- 437.15
- MDL Number:
- MFCD00867812
- MOL File:
- 120068-37-3.mol
| Product description | Number | Pack Size | Price |
| Fipronil European Pharmacopoeia (EP) Reference Standard | Y0001968 | 180 mg | $167 |
| Fipronil PESTANAL | 46451 | 100mg | $256 |
| Fipronil certified reference material, TraceCERT | 16785 | 50mg | $119 |
| Fipronil | F0822 | 1G | $124 |
| Fipronil | F0822 | 5G | $372 |
| More product size | |||
| Melting point | 200-201°C |
|---|---|
| Boiling point | 510.1±50.0 °C(Predicted) |
| Density | 1.477-1.626 |
| vapor pressure | 3.7×10-7 Pa (25 °C) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMSO: 250 mg/mL (571.89 mM) |
| Water Solubility | 1.9-2.4 mg 1l-1 (20 °C） |
| form | Solid |
| pka | -5.86±0.20(Predicted) |
| color | White to Light yellow |
| λmax | 208nm(H2O)(lit.) |
| Merck | 14,4085 |
| BRN | 8090115 |
| Major Application |
agriculture environmental |
| InChI | 1S/C12H4Cl2F6N4OS/c13-5-1-4(11(15,16)17)2-6(14)8(5)24-10(22)9(7(3-21)23-24)26(25)12(18,19)20/h1-2H,22H2 |
| InChIKey | ZOCSXAVNDGMNBV-UHFFFAOYSA-N |
| SMILES | Nc1c(c(nn1-c2c(Cl)cc(cc2Cl)C(F)(F)F)C#N)S(=O)C(F)(F)F |
| LogP | 4.000 |
| CAS DataBase Reference | 120068-37-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | QGH063955F |
| EPA Substance Registry System | Fipronil (120068-37-3) |
| Pesticides Freedom of Information Act (FOIA) | Fipronil |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H311+H331-H372-H410 | |||||||||
| Precautionary statements | P273-P280-P301+P310-P302+P352+P312-P304+P340+P311-P314 | |||||||||
| PPE | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | T,N | |||||||||
| Risk Statements | 23/24/25-48/25-50/53-55-57-36 | |||||||||
| Safety Statements | 26-36/37/39-45-60-61-36/37-28 | |||||||||
| RIDADR | 2588 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UQ4430250 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29331990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Aquatic Acute 1 Aquatic Chronic 1 STOT RE 1 Oral |
|||||||||
| Hazardous Substances Data | 120068-37-3(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 in rats (mg/kg): 100 orally; >2000 dermally (Colliot); in mice (mg/kg): 32 i.p. (Cole) | |||||||||
| NFPA 704 |
|
Fipronil price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | Y0001968 | Fipronil European Pharmacopoeia (EP) Reference Standard | 120068-37-3 | 180 mg | $167 | 2025-07-31 | Buy |
| Sigma-Aldrich | 46451 | Fipronil PESTANAL | 120068-37-3 | 100mg | $256 | 2025-07-31 | Buy |
| Sigma-Aldrich | 16785 | Fipronil certified reference material, TraceCERT | 120068-37-3 | 50mg | $119 | 2025-07-31 | Buy |
| TCI Chemical | F0822 | Fipronil | 120068-37-3 | 1G | $124 | 2025-07-31 | Buy |
| TCI Chemical | F0822 | Fipronil | 120068-37-3 | 5G | $372 | 2025-07-31 | Buy |
Fipronil Chemical Properties,Uses,Production
Description
Fipronil is a white powder with a mouldy odour. It has a low solubility in water and is a slow-acting poison. It does not bind strongly with soil, and the half-life of fipronil– sulphone is 34 days. Fipronil is a broadspectrum insecticide of the phenylpyrazole group. Fipronil was first used extensively for the control of ants, beetles, cockroaches, fleas; ticks, termites, mole crickets, thrips, rootworms, weevils, flea of pets, field pest of corn, golf courses, and commercial turf, and other insects. Fipronil was first used in the United States in 1996. Fipronil is a topical insecticide. It kills adult fleas and larvae, ticks, and chewing lice. As a liquid, fipronil is applied on the back side skin of dogs and cats. Reports indicate that some animals do become hypersensitive (allergic) to fipronil.
Chemical Properties
White crystalline solid.
Chemical Properties
White SOlid
Uses
antifungal
Uses
Pesticide.
Uses
A broad spectrum insecticide which actively disrupts the CNS of contacted insects by blocking the passage of chloride ions through GABA receptors.
Uses
Fipronil is used for the control of a wide range of insect species in rice, cereals, corn, cotton, top fruit, sugar beet, sugar cane, oilseed rape, many vegetables and other high-value crops. It also has a veterinary use as an ectoparasiticide.
Definition
ChEBI: 5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulfinyl]-1H-pyrazole-3-carbonitrile is a member of the class of pyrazoles that is 1H-pyrazole that is substituted at positions 1, 3, 4, and 5 by 2,6-dichloro-4-(trifluoromethyl)phenyl, cyano, (trifluoromethyl)sulfinyl, and amino groups, respectively. It is a nitrile, a dichlorobenzene, a primary amino compound, a member of pyrazoles, a sulfoxide and a member of (trifluoromethyl)benzenes.
Agricultural Uses
Insecticide, Veterinary medicine: Not approved for use in EU countries. Fipronil was introduced into the U.S. in 1996 for use in animal health and indoor pest control. It is the constituent of many products for controlling a wide spectrum of domestic animal and residential pests.
Trade name
BES® 602; CEASEFIRE®; CHIPCO®; COMBAT®; FRONTLINE; MB-46030®; H&G®; ICON®; MAXFORCE® ANT STATION; MAXFORCE® ROACH STATION; REGENCY SOFION®; REGENT®; REGENT® 500-FS; TERMIDOR® L VI-NIL
Pharmacology
Fipronil is a phenylpyrazole, the mode of action of which
is to inhibit nerve transmission in arthropods by blocking
γ -aminobutyric acid-gated chloride channels. Fipronil is
available as spray and spot-on formulations to control
fleas and ticks on cats and dogs. The adulticidal activity of
fipronil accounts for the majority of its activity, although
additional activity against flea eggs and larvae results
from the presence of fipronil on hairs and debris shed into
the environment from treated pets.
Autohistoradiography studies (11) into the cutaneous
distribution of 14C-fipronil in the cat and dog following
spot-on administration demonstrated that radioactivity
was restricted principally to the stratum corneum, the
viable epidermis, and the pilosebaceous units. Following
its slow release from sebaceous glands, fipronil migrates in
the sebum covering the skin and hairs by passive diffusion
and was shown to persist on hair for up to 2 months after
treatment.
Synthesis
120067-83-6
120068-37-3
Example 1: This example illustrates the synthesis of 5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-((trifluoromethyl)sulfinyl)-1H-pyrazole-3-carbonitrile. 100 g (0.23 mol) of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)-4-trifluoromethylthiopyrazole (compound of formula (II)) was dissolved in a solvent mixture consisting of 900 g (6.97 mol) of dichloroacetic acid (DCAA) and 30 g (0.3 mol) of concentrated sulfuric acid. After stirring at 15°C for 30 min, 25 g (0.22 mol) of 30% w/w aqueous hydrogen peroxide solution was slowly added over 90 min. The reaction was continued until HPLC analysis showed a conversion of more than 95%. Upon completion of the reaction, the reaction mixture was quenched using sodium sulfite (Na2SO3). Subsequently, the separation and purification of the product was carried out by conventional methods, resulting in the target product in 98% yield and 97.5% HPLC purity.
Potential Exposure
Pyrazole/phenylpyrazole/organofluor ine insecticide; veterinary medicine. Fipronil was intro duced into the United States in 1996 for use in animal health and indoor pest control. It is the constituent of many products for controlling a wide spectrum of domestic ani mal and residential pests. Banned for use in EU.
Metabolic pathway
Through the abiotic degradation of fipronil in aqueous solution and on the soil surface, 5-amino-3- carbamoyl-1-[2,6-dichloro-4-(trifluoromethyl)-phenyl]-4- [(trifluoromethyl)sulfinyl]pyrazole is the only hydrolysis product detected. Fipronil in acidic aqueous solution exposed under a xenon lamp degrades with the concomitant appearance of 5-amino-3-cyano-1-[2,6- dichloro-4-(trifluoromethyl)-phenyl]-4- (trifluoromethyl)pyrazole and 5-amino-3-cyano-1-[2,6- dichloro-4-(trifluoromethyl)phenyl]pyrazole-4-sulfonic acid. Under field conditions, when fipronil is applied in formulation, four metabolites which include one product resulting from reduction on the sulfur atom of fipronil are detected.
Shipping
UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2902 Pesticide, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Degradation
Fipronil is stable in water at pH 5 and 7 but is slowly hydrolysed at pH 9 (DT50 28 days) to the amide (2). It undergoes rapid aqueous photolysis with a DT50 of ﹤0.5 day. The major photodecomposition product in water and on soil surfaces is desulfinyl-fipronil(3) which is formed by extrusion of the SO group. A minor photoproduct in water, on soil and on plant surfaces is the sulfonic acid (4). The mechanisms of these reactions are discussed in a recent paper by Bobe et al. (1998).
Toxicity evaluation
Acute oral LD50 for rats: 100 mg/kg
Waste Disposal
It is the responsibility of chemical waste generators to determine the toxicity and physical properties and of a discarded chemical and to properly identify its classification and certification as a haz ardous waste and to determine the disposal method. United States Environmental Protection Agency guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult and fol low all regional, national, state and local hazardous waste laws to ensure complete and accurate classification and dis posal methods.
References
[1] Patent: WO2012/7938, 2012, A1. Location in patent: Page/Page column 9-10
[2] Patent: WO2007/122440, 2007, A1. Location in patent: Page/Page column 10-11
[3] Patent: US2009/30211, 2009, A1. Location in patent: Page/Page column 3
[4] Patent: WO2007/122440, 2007, A1. Location in patent: Page/Page column 11
[5] Patent: US2009/30211, 2009, A1. Location in patent: Page/Page column 3
Fipronil Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Liaoning Pharmaceutical Innovation Co., Ltd | +8616588669988 | sales@pipharma.com.cn | China | 151 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8753 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3999 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Qingdao Trust Agri Chemical Co.,Ltd | +86-008615963231493 +86-008613573296305 | trustagri@hotmail.com | China | 301 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 +86-13986145403; | info@fortunachem.com | China | 6011 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5242 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 | deasea125996@gmail.com | China | 2472 | 58 |
| Guangzhou Tengyue Chemical Co., Ltd. | +86-86-18148706580 +8618826483838 | evan@tyvovo.com | China | 143 | 58 |
| Hebei Anlijie Biotechnology Co., Ltd | +8619031013551 | ably@aljbio.com | China | 144 | 58 |
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View Lastest Price from Fipronil manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-01-27 | Fipronil
120068-37-3
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-01-27 | Fipronil
120068-37-3
|
US $0.00-0.00 / Kg/Drum | 1KG | 95%TC; 96%TC; 97%TC | 7000kg/month | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2026-01-21 | Fipronil
120068-37-3
|
US $100.00-75.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD |
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