5-Amino-2-chlorobenzoic acid
- CAS No.
- 89-54-3
- Chemical Name:
- 5-Amino-2-chlorobenzoic acid
- Synonyms
- 2,5-CABA;3-CARBOXY-4-CHLOROANILINE;5-amino-2-chloro-benzoicaci;5-AMINO-2-CHLOROBENZOIC ACID;3-AMINO-6-CHLOROBENZOIC ACID;2-CHLORO-5-AMINO BENZOIC ACID;5-helium-2-chlorobenzoic acid;Benzoic acid, 5-amino-2-chloro-;5-Amino-2-chlorobenzoic acid,97%;5-Amino-2-chlorobenzoic Acid >
- CBNumber:
- CB3466951
- Molecular Formula:
- C7H6ClNO2
- Molecular Weight:
- 171.58
- MDL Number:
- MFCD00007845
- MOL File:
- 89-54-3.mol
- MSDS File:
- SDS
| Melting point | 184-188 °C (lit.) |
|---|---|
| Boiling point | 250°C (rough estimate) |
| Density | 1.5 |
| refractive index | 1.5570 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | 479mg/l |
| form | powder to crystal |
| pka | 1.99±0.25(Predicted) |
| color | White to Light yellow |
| BRN | 2090422 |
| Major Application | peptide synthesis |
| InChI | InChI=1S/C7H6ClNO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3H,9H2,(H,10,11) |
| InChIKey | GVCFFVPEOLCYNN-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC(N)=CC=C1Cl |
| CAS DataBase Reference | 89-54-3(CAS DataBase Reference) |
| EPA Substance Registry System | Benzoic acid, 5-amino-2-chloro- (89-54-3) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29224999 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
5-Amino-2-chlorobenzoic acid price More Price(47)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 532495 | 5-Amino-2-chlorobenzoic acid 97% | 89-54-3 | 25g | $59.1 | 2026-04-30 | Buy |
| TCI Chemical | A1913 | 5-Amino-2-chlorobenzoic Acid >98.0%(HPLC)(T) | 89-54-3 | 25g | $204 | 2026-04-30 | Buy |
| TCI Chemical | A1913 | 5-Amino-2-chlorobenzoic Acid >98.0%(HPLC)(T) | 89-54-3 | 250g | $1410 | 2026-04-30 | Buy |
| TRC | TRC-A604095-1G | 5-Amino-2-chlorobenzoic Acid | 89-54-3 | 1g | $154 | 2026-06-03 | Buy |
| TRC | TRC-A604095-10G | 5-Amino-2-chlorobenzoic Acid | 89-54-3 | 10g | $223 | 2026-06-03 | Buy |
5-Amino-2-chlorobenzoic acid Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
5-Amino-2-chlorobenzoic Acid is a reagent in the preparation of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
2516-96-3
89-54-3
General procedure for the synthesis of 5-amino-2-chlorobenzoic acid from 2-chloro-5-nitrobenzoic acid: 75 g of 2-chloro-5-nitrobenzoic acid, 59 g of iron powder, 800 mL of ethanol, 150 mL of water, and 115 g of ammonium chloride were added to a reaction flask equipped with a stirrer. The mixture was heated to 78-80°C and the reaction was refluxed for 5 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was petroleum ether/ethyl acetate=1:3) during the reaction. Upon completion of the reaction, the reaction mixture was filtered while hot and the solids were washed with 150 mL of hot ethanol. The filtrate was dried at 60°C to obtain the crude product. Subsequently, the crude product was dissolved in 400 mL of ethyl acetate and heated to reflux pulping for 2 hours. The mixture was cooled to 0~5°C in a salt bath and then naturally reduced to room temperature and crystallized for more than 30 minutes. The crystals were separated by centrifugation and washed with 50 mL of ethyl acetate. Finally, it was dried under reduced pressure at 50°C to give 60.7 g of yellow solid 5-amino-2-chlorobenzoic acid with 99.1% purity and 95.1% yield.
References
[1] Arzneimittel-Forschung/Drug Research, 1982, vol. 32, # 3, p. 183 - 186
[2] Chemical and Pharmaceutical Bulletin, 1988, vol. 36, # 9, p. 3462 - 3467
[3] Patent: CN106748721, 2017, A. Location in patent: Paragraph 0029; 0030
[4] Angewandte Chemie - International Edition, 1999, vol. 38, # 18, p. 2777 - 2779
[5] Justus Liebigs Annalen der Chemie, 1868, vol. 147, p. 258
5-Amino-2-chlorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zhengzhou KeYulong chemical products Co., Ltd | 17319789407 17319789407 | Keyulongchem@163.com | China | 1996 | 55 |
| Inner Mongolia Yida Chemical Technology Co., Ltd. | 18967392038 | 67247734@qq.com | China | 75 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| ChemFuture PharmaTech (Jiangsu) Ltd | 5108538618 | suger.wang@chemfuture.com | China | 832 | 65 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
View Lastest Price from 5-Amino-2-chlorobenzoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-05-28 | 5-Amino-2-chlorobenzoic acid
89-54-3
|
$10.70 | 10kg | 99% | 10000kg | Hebei Chuanghai Biotechnology Co,.LTD | |
 |
2026-03-20 | 5-Amino-2-chlorobenzoic acid
89-54-3
|
$10.00 | 1KG | 99% | 10 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-05-23 | 5-Amino-2-chlorobenzoic acid
89-54-3
|
$10.00 | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd |
-
- 5-Amino-2-chlorobenzoic acid
89-54-3
- $10.70
- 99%
- Hebei Chuanghai Biotechnology Co,.LTD
-
- 5-Amino-2-chlorobenzoic acid
89-54-3
- $10.00
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 5-Amino-2-chlorobenzoic acid
89-54-3
- $10.00
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
