Ogerin
- CAS No.
- 1309198-71-7
- Chemical Name:
- Ogerin
- Synonyms
- Ogerin;Ogerin[SML1482];Ogerin >=98% (HPLC);Ogerin, 10 mM in DMSO;(2-(4-Amino-6-(benzylamino)-1,3,5-triazin-2-yl)phenyl)methanol;2-[4-Amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol;Benzenemethanol, 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-;G Protein-Coupled Receptor 68,Inhibitor,TGF-β,inhibit,fibroblasts,fibrotic diseases,Ogerin,GPR68,HEK293,A2A
- CBNumber:
- CB34670516
- Molecular Formula:
- C17H17N5O
- Molecular Weight:
- 307.35
- MDL Number:
- MOL File:
- 1309198-71-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: 50 mg/ml |
| form | powder |
| color | white to beige |
| InChI | 1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22) |
| InChIKey | MDGIEDNDSFMSLP-UHFFFAOYSA-N |
| SMILES | OCC1=C(C2=NC(NCC3=CC=CC=C3)=NC(N)=N2)C=CC=C1 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
Ogerin price More Price(51)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1482 | Ogerin ≥98% (HPLC) | 1309198-71-7 | 5MG | $119 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1482 | Ogerin ≥98% (HPLC) | 1309198-71-7 | 25MG | $480 | 2026-04-30 | Buy |
| Cayman Chemical | 34228 | Ogerin ≥98% | 1309198-71-7 | 1mg | $40 | 2026-04-30 | Buy |
| Cayman Chemical | 34228 | Ogerin ≥98% | 1309198-71-7 | 5mg | $116 | 2026-04-30 | Buy |
| Cayman Chemical | 34228 | Ogerin ≥98% | 1309198-71-7 | 10mg | $207 | 2026-04-30 | Buy |
Ogerin Chemical Properties,Uses,Production
Uses
Ogerin is a potent GPR68 modulator.
Biochem/physiol Actions
Ogerin is a selective positive allosteric modulator of an orphan GPCR, GPR68, also known as Ovarian cancer G-protein coupled receptor 1 (OGR1). GPR68 is one of the proton or pH-sensing GPCRs that sense extracellular H(+). Ogerin potently potentiated proton-mediated GPR68-Gs signaling. Ogerin was not active in GPR68 knockout mice, but was found to suppress recall in fear conditioning in wild-type mice, showing an unexpected effect of GPR68 on learning and memory.
Enzyme inhibitor
This GPR68 activator (FW = 307.35 g/mol; CAS 1309198-71-7), also named 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]benzenemethanol, selectively and allosterically targets G-Protein-coupled Receptor 68, one of at least 120 non-olfactory G-protein-coupled receptors in the human genome that remain 'orphans' (i.e., they are pharmacologically dark, with no known endogenous ligands). Ogerin suppresses recall in fear conditioning in wild-type, but not in GPR68-knockout mice. GPR68 is also a newly recognized metastasis suppressor gene in certain cancers.
in vivo
Ogerin (10 mg/kg; single) shows effects that supports a role for GPR68 in hippocampal-associated memory[2].
| Animal Model: | GPR68 knockout and WT mice[2]. |
| Dosage: | 10 mg/kg |
| Administration: | Single (30 min before the training) |
| Result: | Suppressed recall in fear conditioning in wild-type, but not in GPR68 knockout mice. |
storage
Store at -20°C
Ogerin Preparation Products And Raw materials
Raw materials
Preparation Products
Ogerin Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Rechem science Co., Ltd. | 021-31433387 15618786686 | sales@rechemscience.com | China | 2971 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9699 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5123 | 58 |
