2-Thiopheneglyoxylic acid
- CAS No.
- 4075-59-6
- Chemical Name:
- 2-Thiopheneglyoxylic acid
- Synonyms
- 2-thioylformic acid;RARECHEM AL BO 2203;2-Thiopheneglyoxylic;2-THIENYLGLYOXYLIC ACID;2-Thienylglyoxalic acid;a-Thienylglyoxalic acid;2-THIOPHENEGLYOXYLIC ACID;(2-Thienyl)oxoacetic acid;Oxo(2-thienyl)acetic acid;Thiophen-2-glyoxylic acid
- CBNumber:
- CB3485314
- Molecular Formula:
- C6H4O3S
- Molecular Weight:
- 156.16
- MDL Number:
- MFCD00005441
- MOL File:
- 4075-59-6.mol
- MSDS File:
- SDS
| Melting point | 88-91 °C (lit.) |
|---|---|
| Boiling point | 250.38°C (rough estimate) |
| Density | 1.404 (estimate) |
| refractive index | 1.5151 (estimate) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| pka | 2.09±0.54(Predicted) |
| Sensitive | Hygroscopic |
| BRN | 115791 |
| InChI | 1S/C6H4O3S/c7-5(6(8)9)4-2-1-3-10-4/h1-3H,(H,8,9) |
| InChIKey | GIWRVUADKUVEGU-UHFFFAOYSA-N |
| SMILES | OC(=O)C(=O)c1cccs1 |
| CAS DataBase Reference | 4075-59-6(CAS DataBase Reference) |
| FDA UNII | 723A77PV2M |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 |
| PPE | Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges |
| Hazard Codes | C,Xi |
| Risk Statements | 34 |
| Safety Statements | 26-27-28-36/37/39-45 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| Hazard Note | Irritant |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29349990 |
| Storage Class | 8A - Combustible corrosive hazardous materials |
| Hazard Classifications | Eye Dam. 1 Skin Corr. 1B |
2-Thiopheneglyoxylic acid price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 222275 | 2-Thiopheneglyoxylic acid 95% | 4075-59-6 | 1g | $102 | 2026-04-30 | Buy |
| Usbiological | 290987 | Thiophene-2-glyoxylic acid Asreported | 4075-59-6 | 2g | $319 | 2026-06-03 | Buy |
| Usbiological | 290987 | Thiophene-2-glyoxylic acid Asreported | 4075-59-6 | 5g | $430 | 2026-06-03 | Buy |
| Usbiological | 290987 | Thiophene-2-glyoxylic acid Asreported | 4075-59-6 | 10g | $568 | 2026-06-03 | Buy |
| Usbiological | 290987 | Thiophene-2-glyoxylic acid Asreported | 4075-59-6 | 25g | $745 | 2026-06-03 | Buy |
2-Thiopheneglyoxylic acid Chemical Properties, Uses, Production
Chemical Properties
white to light yellow crystal powder
Uses
2-Thiopheneglyoxylic acid was used in the synthesis of europium complexes.
Synthesis
4075-58-5
4075-59-6
The general procedure for the synthesis of 2-thiophene glyoxalate from ethyl thiophene-2-glyoxalate was as follows: to a solution of ethyl thiophene-2-glyoxalate (4 mL, 27.17 mmol) in ethanol (60 mL) was added an aqueous 4N sodium hydroxide solution (10.2 mL, 40.76 mmol). The reaction mixture was stirred at room temperature for 18 hours. Upon completion of the reaction, the reaction solution was acidified with 2N aqueous hydrochloric acid to pH 2. Subsequently, the solvent was removed by vacuum distillation to afford 2-thiophene glyoxalic acid as a yellow solid product (quantitative yield). The resulting residue was used directly in the subsequent reaction without further purification.LCMS analysis (Method 2): [MH-] = 155 with a retention time of 0.71 min.
References
[1] Patent: WO2016/193244, 2016, A1. Location in patent: Page/Page column 80
[2] Chemical Communications, 2014, vol. 50, # 34, p. 4489 - 4491
[3] Patent: WO2016/177849, 2016, A1. Location in patent: Page/Page column 60
[4] Advanced Synthesis and Catalysis, 2018, vol. 360, # 21, p. 4184 - 4190
2-Thiopheneglyoxylic acid Preparation Products And Raw materials
2-Thiopheneglyoxylic acid Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
View Latest Price from 2-Thiopheneglyoxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-07 | 2-Thiopheneglyoxylic acid
4075-59-6
|
10KG | 99%+ | 10000KG | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2020-02-18 | 2-Thiopheneglyoxylic acid
4075-59-6
|
$8.00 | 1KG | ＞98% HPLC | 20 tons | Career Henan Chemical Co |
-
- 2-Thiopheneglyoxylic acid
4075-59-6
- 99%+
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Thiopheneglyoxylic acid
4075-59-6
- $8.00
- ＞98% HPLC
- Career Henan Chemical Co
