Menbutone
- CAS No.
- 3562-99-0
- Chemical Name:
- Menbutone
- Synonyms
- menbutone;menbuton;genabil;3-(4-METHOXY-1-NAPHTHOYL)PROPIONIC ACID;fel-bis;Icteryl;SC 1749;naftobil;epanaftol;genabilin
- CBNumber:
- CB3489226
- Molecular Formula:
- C15H14O4
- Molecular Weight:
- 258.27
- MDL Number:
- MFCD00021539
- MOL File:
- 3562-99-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Menbutone ≥98% | CS-4741 | 25g | $43 |
| Menbutone ≥98% | CS-4741 | 100g | $162 |
| 4-(4-Methoxynaphthalen-1-yl)-4-oxobutanoic acid | 089746 | 10.00g | $31 |
| 4-(4-Methoxynaphthalen-1-yl)-4-oxobutanoic acid | 089746 | 25.00g | $52 |
| 4-(4-Methoxynaphthalen-1-yl)-4-oxobutanoic acid | 089746 | 100.00g | $190 |
| More product size | |||
| Melting point | 172-173° |
|---|---|
| Boiling point | 361.52°C (rough estimate) |
| Density | 1.2105 (rough estimate) |
| refractive index | 1.4872 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated), Ethanol (Slightly, Heated) |
| form | Solid |
| pka | 4.44±0.17(Predicted) |
| color | White to Off-White |
| InChI | InChI=1S/C15H14O4/c1-19-14-8-6-11(13(16)7-9-15(17)18)10-4-2-3-5-12(10)14/h2-6,8H,7,9H2,1H3,(H,17,18) |
| InChIKey | FHGJSJFIQNQBCK-UHFFFAOYSA-N |
| SMILES | C12C=CC=CC1=C(OC)C=CC=2C(=O)CCC(=O)O |
| FDA UNII | 341YM32546 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
Menbutone price More Price(29)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-4741 | Menbutone ≥98% | 3562-99-0 | 25g | $43 | 2026-06-04 | Buy |
| ChemScene | CS-4741 | Menbutone ≥98% | 3562-99-0 | 100g | $162 | 2026-06-04 | Buy |
| Matrix Scientific | 089746 | 4-(4-Methoxynaphthalen-1-yl)-4-oxobutanoic acid | 3562-99-0 | 10.00g | $31 | 2026-05-18 | Buy |
| Matrix Scientific | 089746 | 4-(4-Methoxynaphthalen-1-yl)-4-oxobutanoic acid | 3562-99-0 | 25.00g | $52 | 2026-05-18 | Buy |
| Matrix Scientific | 089746 | 4-(4-Methoxynaphthalen-1-yl)-4-oxobutanoic acid | 3562-99-0 | 100.00g | $190 | 2026-05-18 | Buy |
Menbutone Chemical Properties,Uses,Production
Originator
Hepalande, Delalande ,W. Germany ,1977
Uses
Menbutone is a cholerectic compound which is used for stimulating gastro-intestinal function by promoting secretory processes in animals including that of cattle, sheep, goats, horses and dogs. It is used in treatment of hepatic dysfunction of dogs by promoting bile secretion.
Definition
ChEBI: Menbutone is a butanone.
Manufacturing Process
395 parts of (α-methoxynaphthalene and 265 parts of succinic anhydride are dissolved in 8,000 parts of dry benzene at room temperature. The resulting solution is stirred and 710 parts of anhydrous aluminum chloride are added over a period of twenty minutes. During the addition the temperature of the reaction mixture rises to about 60°C to 70°C. After the addition the reaction mixture is stirred for fifteen or twenty minutes at 60°C to 70°C and then refluxed for one hour. The hot reaction mixture is then poured onto a mixture of 5,000 parts of ice and 900 parts of concentrated hydrochloric acid. The benzene is removed by steam distillation and the hot aqueous residue is filtered to remove the insoluble β-(1-methoxy-4-naphthoyl)-propionic acid. The residue of the latter is dried and then dissolved in 16,000 parts of hot water containing 300 parts of sodium carbonate. The hot solution is treated with activated charcoal, filtered while hot, chilled and acidified. The residue of purified acid is collected on a filter, washed with water, and dried at 65°C. A yield of 552 parts of purified β-(1-methoxy)-4-naphthoyl)propionic acid, melting at 172°C to 173°C is obtained.
Therapeutic Function
Choleretic
Synthesis
Menbutone is prepared by the reaction of succinic acid anhydride and 1-Methoxynaphthalene. The steps are as follows:
15.8 g of 1-methoxynaphthalene and 10.0 g of succinic anhydride were dissolved in 120 mL of dichloromethane,Stir, Cooling to 1 ~ 3 ° C, Divided into three batches of anhydrous aluminum trichloride 15.0 grams, The addition process takes about 20 minutes, The solution was then heated to 35 ± 2 ° C, Insulation reaction 6 hours (5.5 ~ 6.5 hours range), After the reaction is complete, The reaction solution was poured into an ice-water mixture (200 g of ice and 300 g of water) for 30 minutes,Standing, analysiscrystal, Filter, The filtrate was heated and distilled to recover dichloromethane, The cake is the crude of the ketone ketone; And then the crude ketoprofen water as a solvent by 2-3 times recrystallization, Activated carbon decolorization, Demon ketone boutique. The mass of the present product of the compound was 22.3 g, Melting point of 176 ~ 179 ° C, The yield was 86.4%.
References
[1] Patent: CN104370734, 2016, B. Location in patent: Paragraph 0016-0018
[2] Helvetica Chimica Acta, 1932, vol. 15, p. 907,914
[3] Journal of the University of Bombay, Science: Physical Sciences, Mathematics, Biological Sciences and Medicine, 1936, vol. 5/2, p. 73,75
[4] Journal of the American Chemical Society, 1940, vol. 62, p. 2750,2752
[5] Journal of the American Chemical Society, 1951, vol. 73, p. 897,899
Menbutone Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| shandong perfect biotechnology co.ltd | +86-53169958659 +86-13153181156 | sales@sdperfect.com | China | 294 | 58 |
| Henan Suikang Pharmaceutical Co.,Ltd. | +86-18239973690 | sales@suikangpharm.com | China | 311 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1006 | 58 |
| Sinoway Industrial co., ltd. | +86-0592-5800732 +86-13806035118 | xie@china-sinoway.com | China | 1369 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| SIMAGCHEM CORP | +86-5922680277 +86-13806087780 | sale@simagchem.com | China | 17346 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32466 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34563 | 58 |
View Lastest Price from Menbutone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-29 | Menbutone
3562-99-0
|
1kg | 98.0 % up?by HPLC | 20tons | Sinoway Industrial co., ltd. | ||
 |
2026-07-28 | Menbutone
3562-99-0
|
1KG | 98% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2026-07-04 | Menbutone
3562-99-0
|
$29.00 | 99.40% | 10g | TargetMol Chemicals Inc. |
