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POLYTHIAZIDE (200 MG)

POLYTHIAZIDE (200 MG) structure

CAS No.: 346-18-9

Chemical Name:: POLYTHIAZIDE (200 MG)

Synonyms: polythiazide;p2525;P 2525;Renese;Nephril;Drenusil;NSC-108161;Drenusilnephril;POLYTHIAZIDE (200 MG);Polythiazide Solution, 100ppm

CBNumber:: CB3500394

Molecular Formula:: C11H13ClF3N3O4S3

Molecular Weight:: 439.8818296

MDL Number:: MFCD00072071

MOL File:: 346-18-9.mol

MSDS File:: SDS

Last updated:2026-05-28 02:30:47

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POLYTHIAZIDE (200 MG) Properties

Melting point	202.5°
Boiling point	580.1±60.0 °C(Predicted)
Density	1.8346 (rough estimate)
refractive index	1.6100 (estimate)
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly, Heated)
pka	pKa 9.58(H2O,t =25) (Uncertain)
form	Solid
color	White to Off-White
FDA UNII	36780APV5N
ATC code	C03AA05
EPA Substance Registry System	Polythiazide (346-18-9)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P330-P501
Hazardous Substances Data	346-18-9(Hazardous Substances Data)

POLYTHIAZIDE (200 MG) price More Price(15)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	TRC-P689410-10MG	Polythiazide >95%(HPLC)	346-18-9	10mg	$325	2026-06-03	Buy
TRC	TRC-P689410-100MG	Polythiazide >95%(HPLC)	346-18-9	100mg	$2399	2026-06-03	Buy
ChemScene	CS-0006323	Polythiazide	346-18-9	1mg	$160	2026-06-04	Buy
ChemScene	CS-0006323	Polythiazide	346-18-9	5mg	$448	2026-06-04	Buy
ChemScene	CS-0006323	Polythiazide	346-18-9	10mg	$718	2026-06-04	Buy

Product number	Packaging	Price	Buy
TRC-P689410-10MG	10mg	$325	Buy
TRC-P689410-100MG	100mg	$2399	Buy
CS-0006323	1mg	$160	Buy
CS-0006323	5mg	$448	Buy
CS-0006323	10mg	$718	Buy

POLYTHIAZIDE (200 MG) Chemical Properties, Uses, Production

Description

Polythiazide exhibits a more pronounced antihypertensive effect than chlorothiazide and it may be used independently for the same indications as the aforementioned drugs. However, it is primarily used as an ingredient of a combination drugs intended for lowering pressure, in particular in minizide, which is a combination of prazozine and polythiazide.

Originator

Renese ,Pfizer, US ,1961

Uses

Polythiazide is a thiazide diuretic. Polythiazide is used in the treatment of hypertension as well as nephrotic syndrome, cirrhosis of the liver, and nutritional edema.

Definition

ChEBI: Polythiazide is a benzothiadiazine.

Manufacturing Process

(A) Preparation of trifluoroethylthioacetaldehyde dimethylacetal: To 4.6 g (0.2 mol) of metallic sodium dissolved in 75 ml of absolute methanol is rapidly added 24.4 g (0.2 mol) of mercaptoacetaldehyde dimethylacetal followed by dropwise addition of 42.0 g (0.2 mol) of trifluoroethyl iodide.
The resulting reddish mixture is refluxed on a steam bath for one hour. One half of the alcohol is removed by concentration and the remainder diluted with several volumes of water and extracted with ether. The combined ether extracts are dried over sodium sulfate, the ether then removed at reduced pressure and the residue distilled to about 30 g (BP 82°C/25 mm).
(B) Preparation of 4-Amino-2-Chloro-5-(Methylsulfamyl)Benzenesulfonamide: The 5-substituted-2,4-disulfamyl anilines may be prepared by procedures described in the literature, for example, the general procedures in Monatsch. Chem. vol. 48, p 87 (1927), which involves the treatment of a m-substituted aniline with from 10 to 20 parts by weight of chlorosulfonic acid followed by the gradual addition of from about 90 to 170 parts by weight of sodium chloride. The resultant mixture is heated at approximately 150°C for about 2hours after which the reaction mixture is poured into water and the resultant 5substituted aniline-2,4-disulfonyl chloride is filtered and is then treated with concentrated ammonium hydroxide or suitable amine by standard procedures to obtain the corresponding disulfonamide.
(C) Preparation of 2-Methyl-3-(2,2,2-Trifluoroethyl)Thiomethyl-6-Chloro-7Sulfamyl-3,4-Dihydro-1,2,4-Benzothiadiazine-1,1-Dioxide: To 4.6 g (0.015 mol) of 4-amino-2-chloro5-(methylsulfamyl)benzenesulfonamide in 30 ml of the dimethyl ether of ethylene glycol is added 4.08 g (0.02 mol) of 2,2,2trifluoroethylmercaptoacetaldehyde dimethylacetal followed by 1 ml of ethyl acetate saturated with hydrogen chloride gas. The resulting solution is refluxed for 1.5 hours, cooled and then slowly added to cold water dropwise with stirring. The crude product is filtered, dried and recrystallized from isopropanol (3.2 g), MP 202° to 202.5°C. A second recrystallization from isopropanol raised the MP to 202° to 203°C.

brand name

Renese (Pfizer).

Therapeutic Function

Diuretic

General Description

Crystals or white powder.

Air & Water Reactions

Its rate of decomposition in solution increases with an increase in pH. . Insoluble in water.

Reactivity Profile

POLYTHIAZIDE (200 MG) is a sulfonamide derivative. With strong reducing agents will produce hydrogen sulfide gas.

Fire Hazard

Flash point data for POLYTHIAZIDE (200 MG) are not available, but POLYTHIAZIDE (200 MG) is probably combustible.

Synthesis

Polythiazide, 1,1-dioxide 2-methyl-3-(2,2,2-trifluoroethylthiomethyl)-6- chloro-3,4-dihydro-2H-1,2,4-benzothiadiazin-7-sulfonamide (21.3.8), is also synthesized by an analogous scheme, which is by condensing 4-aminosulfonyl-5-chloro-2-methylaminosulfonylaniline (21.3.7) with 2,2,2-trifluoroethylthioacetaldehyde dimethylacetal.

Synthesis_346-18-9

POLYTHIAZIDE (200 MG) Preparation Products And Raw materials

Raw materials

METHYCLOTHIAZIDE RELATED COMPOUND A (100 MG) (4-AMINO-6-CHLORO-N-3-METHYL-M-BEN-ZENEDISULFONAMIDE) 2-Iodo-1,1,1-trifluoroethane 2,2-dimethoxyethanethiol Sodium

Preparation Products

POLYTHIAZIDE (200 MG) Suppliers

Global Suppliers ( 45)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10628	60
Alta Scientific Co., Ltd.	022-6537-8550 15522853686	sales@altasci.com.cn	China	4508	55
Shenzhen Polymeri Biochemical Technology Co., Ltd.	+86-400-002-6226	sales@rrkchem.com	China	57336	58
Career Henan Chemica Co	+86-0371-86658258 +86-13203830695	laboratory@coreychem.com	China	30203	58
Guangzhou Younan Technology Co., Ltd	020-82000279 18988941452	YN_research@163.com	China	2984	58
Wuhan pengyin Pharmaceutical Co., Ltd	13163333255	1939328613@qq.com	China	392	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-025-85560043 17301488900	info@synzest.com	China	9274	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44871	58

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Chemsky（shanghai）International Co.,Ltd.	50
HBCChem, Inc.	60
Alta Scientific Co., Ltd.	55
Shenzhen Polymeri Biochemical Technology Co., Ltd.	58
Career Henan Chemica Co	58
Guangzhou Younan Technology Co., Ltd	58
Wuhan pengyin Pharmaceutical Co., Ltd	58
Nanjing Shizhou Biology Technology Co.,Ltd	58
Energy Chemical	58

346-18-9 (POLYTHIAZIDE (200 MG)) Related Search:

Bumetanide Clofenamide 2,2,2-Trifluoroethanethiol 4-Chloro-1,3-benzenedithiol 2-Amino-N-methylbenzenesulfonamide

Benzenesulfonamide, 2-(methylamino)- (9CI) 4-Chloro-N-methylbenzenesulphonamide o-Chlorobenzenesulfonamide Hydrochlorothiazide 2-Aminobenzenesulfonamide

2-amino-N,N-dimethylbenzenesulfonamide POLYTHIAZIDE (200 MG) 4-Amino-6-chlorobenzene-1,3-disulfonamide Flurese

1of3

2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-2-methyl-3-(((2,2 2h-benzo-1,2,4-thiadiazine1,1-dioxide 2-methyl-3-(beta,beta,beta-trifluoroethylthiomethyl)-6-chloro-7-sulfamyl-3,4-d 6-Chloro-2-methyl-3-([(2,2,2-trifluoroethyl)sulfanyl]methyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 6-Chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide 6-Chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoromethyl)thio]methyl]-2H-1,2,4-benzothiadiazine -7-sulfonamide 1,1-dioxide benzothiadiazine-7-sulfonamide1,1-dioxide Drenusil Drenusilnephril ihydro-1,2,4-benzothiadiazine1,1-dioxide Nephril NSC-108161 P 2525 6-Chloro-3,4-dihydro-2-Methyl-3-[[2,2,2-trifluoroethyl)thio]Methyl]-2H-1,2,4-benzothiadiazine-7-sulfonaMide 1,1-Dioxide 6-Chloro-3,4-dihydro-2-Methyl-7-sulfaMoyl-3-(2,2,2-trifluoroethylthioMethyl)-2H-1,2,4-benzothiadiazine 1,1-Dioxide Polythiazide Solution, 100ppm ,2-trifluoroethyl)thio)methyl)-,1,1-dioxide 2,2-trifluoroethyl)thio)methyl)-,1,1-dioxide 2,2-trifluoroethyl)thio]methyl]-2h-1,2,4-6-chloro-4-dihydro-2-methyl-3-[[(2 2,2-trifluoroethylthiomethyl)-6-chloro-4-dihydro-2-methyl-7-sulphamoyl-3-(2 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-[[(2,2,2-trifluoroethyl)thio]methyl]-, 1,1-dioxide 2h-1,2,4-benzothiadiazine-7-sulfonamide,6-chloro-3,4-dihydro-2-methyl-3-(((2, p2525 Renese POLYTHIAZIDE (200 MG) 2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(2,2,2-trifluoroethyl)thiomethyl-, 1,1-dioxide 6-chloro-1,1-diketo-2-methyl-3-[(2,2,2-trifluoroethylthio)methyl]-3,4-dihydrobenzo[e][1,2,4]thiadiazine-7-sulfonamide 6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydrobenzo[e][1,2,4]thiadiazine-7-sulfonamide POLYTHIAZIDE (200 MG) USP/EP/BP polythiazide 346-18-9 C11H13ClF3N3O4S3