2-Piperidone
- CAS No.
- 675-20-7
- Chemical Name:
- 2-Piperidone
- Synonyms
- piperidin-2-one;2-PIPERIDINONE;VALEROLACTAM;DELTA-VALEROLACTAM;Piperidon;5-Aminovaleric acid lactam;valerolactim;D-VALEROLACTAM;6-VALEROLACTAM;ALPHA-PIPERIDONE
- CBNumber:
- CB3680771
- Molecular Formula:
- C5H9NO
- Molecular Weight:
- 99.13
- MDL Number:
- MFCD00006037
- MOL File:
- 675-20-7.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| δ-Valerolactam 98% | V209 | 25g | $88.6 |
| δ-Valerolactam 98% | V209 | 100g | $233 |
| 2-Piperidone >98.0%(GC) | P0455 | 25g | $68 |
| 2-Piperidone >98.0%(GC) | P0455 | 100g | $184 |
| δ-Valerolactam | 469822 | 25g | $326 |
| More product size | |||
| Melting point | 38-40 °C (lit.) |
|---|---|
| Boiling point | 256 °C (lit.) 81-82 °C/0.1 mmHg (lit.) |
| Density | 1.073 |
| refractive index | 1.4431 (estimate) |
| Flash point | >230 °F |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Low Melting Crystalline Mass |
| color | White to yellow to brown |
| PH | 4.8 (200g/l, H2O, 20℃) |
| explosive limit | 1.5-8.7%(V) |
| Water Solubility | 291 g/L (25 ºC) |
| Sensitive | Hygroscopic |
| BRN | 106434 |
| Stability | Stable under recommended storage conditions., Stable Under Recommended Storage C |
| InChI | 1S/C5H9NO/c7-5-3-1-2-4-6-5/h1-4H2,(H,6,7) |
| InChIKey | XUWHAWMETYGRKB-UHFFFAOYSA-N |
| SMILES | O=C1CCCCN1 |
| CAS DataBase Reference | 675-20-7(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | WLN0GQQ6EK |
| NIST Chemistry Reference | 2-Piperidinone(675-20-7) |
| EPA Substance Registry System | 2-Piperidone (675-20-7) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280-P305+P351+P338-P337+P313 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37-36/37/38 | |||||||||
| Safety Statements | 22-24/25-37/39-26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TO0110000 | |||||||||
| F | 3-10 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29337900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 | |||||||||
| NFPA 704 |
|
2-Piperidone price More Price(65)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | V209 | δ-Valerolactam 98% | 675-20-7 | 25g | $88.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | V209 | δ-Valerolactam 98% | 675-20-7 | 100g | $233 | 2026-04-30 | Buy |
| TCI Chemical | P0455 | 2-Piperidone >98.0%(GC) | 675-20-7 | 25g | $68 | 2026-04-30 | Buy |
| TCI Chemical | P0455 | 2-Piperidone >98.0%(GC) | 675-20-7 | 100g | $184 | 2026-04-30 | Buy |
| Usbiological | 469822 | δ-Valerolactam | 675-20-7 | 25g | $326 | 2026-06-03 | Buy |
2-Piperidone Chemical Properties,Uses,Production
Chemical Properties
white to yellowish low melting crystalline mass
Uses
δ-Valerolactam is a useful synthetic intermediate. It is an intermediate used to synthesize Cenicriviroc (C256550), an experimental drug candidate for the treatment of HIV infection. It is also a starting material for a new route to hexahydrojulolidines, using intramolecular 1,4-cycloaddition.
Definition
ChEBI: 2-Piperidone is a delta-lactam that is piperidine which is substituted by an oxo group at position 2. It has a role as an EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor. It is a member of piperidones and a delta-lactam.
Preparation
2-Piperidone can be obtained from cyclopentanone as raw material by a two-step reaction.
Synthesis Reference(s)
Journal of the American Chemical Society, 102, p. 7629, 1980 DOI: 10.1021/ja00546a001
Tetrahedron Letters, 28, p. 2829, 1987 DOI: 10.1016/S0040-4039(00)96220-8
The Journal of Organic Chemistry, 21, p. 965, 1956 DOI: 10.1021/jo01115a010
Purification Methods
Purify it by repeated fractional distillation.[Cowley J Org Chem 23 1330 1958, Reppe et al. Justus Liebigs Ann Chem 596 198 1955, IR: Huisgen et al. Chem Ber 90 1437 1957.] The hydrochloride has m 183-184o (from isoPrOH or EtOH/Et2O) [Hurd et al. J Org Chem 17 865 1952], and the oxime has m 122.5o (from pet ether) [Behringer & Meier Justus Liebigs Ann Chem 607 67 1957]. The picrate has m 92-93o. [Beilstein 21 H 239, 21 III/IV 3170, 21/6 V 396.]
2-Piperidone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21533 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29766 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88298848 | info@edengenechem.com | China | 2163 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1056@dideu.com | China | 3970 | 58 |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-0519-85551759 | marketing1@neostarunited.com | China | 8827 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Shanghai UCHEM Inc. | +86-18930848214 +86-021-56762820 | sales@myuchem.com | China | 8898 | 58 |
| Baoji Guokang Healthchem Co., Ltd. | +86-0917-3909592 +86-13892490616 | gksales1@gk-bio.com | China | 9036 | 58 |
View Lastest Price from 2-Piperidone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-21 | 2-Piperidone
675-20-7
|
$3.00-23.00 | 1kg | 99% | 300tons | Hebei Dangtong Import and export Co LTD | |
 |
2026-02-02 | 2-Piperidone
675-20-7
|
1g | 99% | 2000tons | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2024-04-07 | 2-Piperidone
675-20-7
|
$18.00-23.00 | 1kg | 99% | 5000tons | Wuhan Boyuan Import & Export Co., LTD |
-
- 2-Piperidone
675-20-7
- $3.00-23.00
- 99%
- Hebei Dangtong Import and export Co LTD
-
- 2-Piperidone
675-20-7
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Piperidone
675-20-7
- $18.00-23.00
- 99%
- Wuhan Boyuan Import & Export Co., LTD
