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3,5-Diiodo-L-tyrosine dihydrate

3,5-Diiodo-L-tyrosine dihydrate Structure
3,5-Diiodo-L-tyrosine dihydrate structure
CAS No.
300-39-0
Chemical Name:
3,5-Diiodo-L-tyrosine dihydrate
Synonyms
(S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid;diiodotyrosine;L-3,5-DiioDOTyrosine;Liothyronine sodium EP Impurity B;AGONTAN;DITYRIN;3,5-Diiodo-L;L-Diiodotyrosine;H-TYR(3,5-I2)-OH;IODOGORGOIC ACID
CBNumber:
CB5490149
Molecular Formula:
C9H9I2NO3
Molecular Weight:
432.98
MDL Number:
MFCD00016542
MOL File:
300-39-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-06-03 18:11:14
Product description Number Pack Size Price
3,5-Diiodo-L-tyrosine ≥98% 36266 10g $32
3,5-Diiodo-L-tyrosine ≥98% 36266 25g $74
3,5-Diiodo-L-tyrosine ≥98% 36266 50g $118
3,5-Diiodo-L-tyrosine ≥98% 36266 100g $217
3,5-Diiodo-L-tyrosine 427436 1g $340
More product size
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3,5-Diiodo-L-tyrosine dihydrate Properties

Melting point 200 °C (dec.)(lit.)
alpha -20.7 º (c=2.5, 0.1N NaOH/H2O)
Boiling point 546.5°C (rough estimate)
Density 2.405±0.06 g/cm3(Predicted)
refractive index 1.2 ° (C=5, 1mol/L HCl)
storage temp. 2-8°C
solubility Aqueous Acid (Slightly), DMSO (Slightly)
form crystalline
pka 2.12(at 25℃)
color white
Water Solubility slightly soluble
Sensitive Light Sensitive
Major Application pharmaceutical
CAS DataBase Reference 300-39-0(CAS DataBase Reference)
FDA UNII 6L57Q44ZWW
ATC code H03BX01
NIST Chemistry Reference 3,5-Diiodo-l-tyrosine(300-39-0)
EPA Substance Registry System L-Tyrosine, 3,5-diiodo- (300-39-0)
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-37/39-36/37-24/25
RIDADR  2811
WGK Germany  3
F  8
TSCA  TSCA listed
HS Code  29225090
Storage Class 11 - Combustible Solids
REACH Registrations Active
NFPA 704
0
2 0

3,5-Diiodo-L-tyrosine dihydrate price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 36266 3,5-Diiodo-L-tyrosine ≥98% 300-39-0 10g $32 2026-04-30 Buy
Cayman Chemical 36266 3,5-Diiodo-L-tyrosine ≥98% 300-39-0 25g $74 2026-04-30 Buy
Cayman Chemical 36266 3,5-Diiodo-L-tyrosine ≥98% 300-39-0 50g $118 2026-04-30 Buy
Cayman Chemical 36266 3,5-Diiodo-L-tyrosine ≥98% 300-39-0 100g $217 2026-04-30 Buy
Usbiological 427436 3,5-Diiodo-L-tyrosine 300-39-0 1g $340 2026-06-03 Buy
Product number Packaging Price Buy
36266 10g $32 Buy
36266 25g $74 Buy
36266 50g $118 Buy
36266 100g $217 Buy
427436 1g $340 Buy

3,5-Diiodo-L-tyrosine dihydrate Chemical Properties,Uses,Production

Description

Diiodotyrosine does not possess pronounced hormonal activity. However, it stops production of thyrotropic hormone by the anterior lobe of the hypophysis, which activates thyroid gland activity.

Chemical Properties

white to beige powder

Uses

It is used for hyperthyroid forms of endemic and sporadic goiters, diffuse, toxic goiters, and other illnesses accompanied by thyrotoxicity.

Uses

3,5-Diiodo-L-tyrosine is a reactant used in the synthesis of fluorescent unnatural amino acids bearing stilbene or vinylene backbones. Also used in the discovery of potent heterodimeric antagonists of inhibitor of Apoptosis proteins with prolonged anti-tumor activity.

Uses

3,5-Diiodo-L-tyrosine Dihydrate is a thyroid hormone receptor agonist.

Definition

ChEBI: A diiodotyrosine that is L-tyrosine carrying iodo-substituents at positions C-3 and C-5 of the benzyl group. It is an intermediate in the thyroid hormone synthesis.

Synthesis

Diiodotyrosine, 3,5-diiodotyrosine (25.2.1), is synthesized by directly iodinating tyrosine with iodine in the presence of sodium iodide in aqueous ethylamine, or in a mixture of acetic and hydrochloric acids with the addition of hydrogen peroxide.

Synthesis_300-39-0

Purification Methods

It forms crystals from H2O [solubility (g/L): 0.204 at 0o, 1.86 at 50o, 5.6 at 75o and 17.0 at 100o]. Also recrystallise it from 50% or 70% EtOH. When boiled in EtOH the crystals swell, and on further boiling a gelatinous precipitate is formed [Harrington Biochem J 22 1434 1928, Jurd J Am Chem Soc 77 5747 1955]. It also crystallises from cold dilute ammonia on adding acetic acid to pH 6. [Beilstein 14 IV 2370.]

3,5-Diiodo-L-tyrosine dihydrate synthesis

60-18-4
300-39-0
Synthesis of 3,5-Diiodo-L-tyrosine dihydrate from L-Tyrosine

3,5-Diiodo-L-tyrosine dihydrate Preparation Products And Raw materials

Raw materials

L-Tyrosine Ammonia Iodine

Preparation Products

Levothyroxine 3-IODO-L-TYROSINE N-Acetyl-3,5-diiodo-L-tyrosine ethyl ester 4-Hydroxyphenylacetamide METHYL 3,5-DIIODO-L-TYROSINATE
BOC-3,5-DIIODO-L-TYROSINE

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3,5-Diiodo-L-tyrosine dihydrate Suppliers

Global( 329)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+86-17531190177 faithe@yan-xi.com China 5853 58
Shaanxi Didu New Materials Co. Ltd 		+86-86-17392712779 +86-13289823923 1090@dideu.com China 8660 58
Hebei Chuanghai Biotechnology Co., Ltd 		+86-17732866630 mina@chuanghaibio.com China 18126 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806 sales@capot.com China 29640 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-2158073036 info@dakenam.com China 14026 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21585 55
GenicBio Limited 		+86-21-37621270 service@genicbio.com CHINA 991 58
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29812 58
Shanghai Worldyang Chemical Co.,Ltd. 		+86-021-56795779 +86-13651600618 sales@worldyachem.com China 967 58
Xiamen AmoyChem Co., Ltd 		+86-86-5926051114 sales@amoychem.com China 6366 58
Supplier Advantage
Hebei Yanxi Chemical Co., Ltd. 		58
Shaanxi Didu New Materials Co. Ltd 		58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Henan Tianfu Chemical Co.,Ltd. 		55
GenicBio Limited 		58
career henan chemical co 		58
Shanghai Worldyang Chemical Co.,Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58

View Lastest Price from 3,5-Diiodo-L-tyrosine dihydrate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3,5-Diiodo-L-tyrosine dihydrate pictures 2026-07-31 3,5-Diiodo-L-tyrosine dihydrate
300-39-0
 100g 98%min 100kgs WUHAN FORTUNA CHEMICAL CO., LTD
3,5-Diiodo-L-tyrosine dihydrate pictures 2026-06-03 3,5-Diiodo-L-tyrosine dihydrate
300-39-0
 $1.50 1g 99.0% Min 100 Tons Shaanxi Didu New Materials Co. Ltd
3,5-Diiodo-L-tyrosine dihydrate pictures 2026-05-11 3,5-Diiodo-L-tyrosine dihydrate
300-39-0
 $39.00 99.32% 10g TargetMol Chemicals Inc.

3,5-Diiodo-L-tyrosine dihydrate Spectrum

3,5-Diiodo-L-tyrosine dihydrate(300-39-0)MS3,5-Diiodo-L-tyrosine dihydrate(300-39-0)1HNMR3,5-Diiodo-L-tyrosine dihydrate(300-39-0)IR13,5-Diiodo-L-tyrosine dihydrate(300-39-0)IR2

300-39-0(3,5-Diiodo-L-tyrosine dihydrate)Related Search:

Prostratin, PKC activator H-ARG-ARG-LEU-ILE-GLU-ASP-ASN-GLU-TYR-THR-ALA-ARG-GLY-OH L-Alanine Boc-D-Tyr-OH L-Tyrosine
2',6'-Pipecoloxylidide 2-Piperidone 3,3',5,5'-TETRAIODOTHYRO-ACETIC ACID 3,4-Dimethoxy-L-phenylalanine FMOC-3,5-DIIODO-L-TYROSINE
N-Acetyl-3,5-Diiodo-L-tyrosine dihydrate 3 5-DIIODO-L-TYROSINE DIHYDRATE 98%,3 5-DIIODO-L-TYROSINE DIHYDRATE 98 Levothyroxine sodium Sodium levothyroxine Liothyronine sodium
3,3',5-Triiodo-L-thyronine Levothyroxine 3,5-Diiodo-L-thyronine

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3,5-Diiodo-L-tyrosine dihydrate, BR Liothyronine EP Impurity B 3,5-Diiodo-4-hydroxy-β-phenylalanine 3,5-diiodo-l-tyrosin 3,5-Diiodotyrocine 3,5-Iodo-L-tyrosine 3,5-L-Diiodotyrosine 4-Hydroxy-3,5-diiodophenylalanine diiodotyrosine L-3,5-DiioDOTyrosine Tryosine, 3,5-diiodo- Tyrosine, 3,5-diiodo-, L- L-Diiodotyrosine 3,5-Diiodo-L-tyrosine dihydrate,99% 5-Diiodo-L-tyrosinedehydrate L-4-hydroxy-3,5-diiodo-phenylalanine DI-IODO-L-TYROSINE(P) 3,5-Diiodo-L-Tyr-OH 3,7-DibroMo-L-Tyrosine 3,5-Diiodo-L-Tyr-OH, 98.5% (2S)-2-amino-3-(4-hydroxy-3,5-diiodo-phenyl)propanoic acid H-Tyr(3,5-Di-I)-OH 3,5-Diiodo-L-tyrosinedehydrate 3,5-DIIODO-4-HYDROXY-BETA-PHENYLALANINE 3,5-DIIODINE-L-TYROSINE 3,5-DIIODO-BETA(4-HYDROXYPHENYL)ALANINE 3,5-DIIODO-TYROSINE 4-HYDROXY-3,5-DIIODOPHENYLALANINE, 2-AMINO-3-(4-HYDROXY-3,5-DIIODOPHENYL)PROPIONIC ACID AGONTAN L-TYROSINE, 3,5-DIIODO- DITYRIN H-TYR(3,5-I2)-OH IODOGORGOIC ACID H-3,5-DIIODO-TYR-OH H-L-TYR(3,5-I2)-OH 3,5-Diiodo-beta-(p-hydroxyphenyl)alanine dihydrate H-L-Tyr(3,5-I2)-OH*2H2O 3,5-Diiodo-L -tyrosine dihydrate Levofolinate Impurity 2 (Liothyronine EP Impurity B) 3,5-Diiodo-L-tyrosine dihydrate USP/EP/BP Liothyronine sodium EP Impurity B TIANFU CHEM--3,5-Diiodo-L-tyrosine dihydrate Liothyronine Impurity 2 (Liothyronine EP Impurity B) DIIODO-L-TYROSINE 3,5-Diiodo-L-tyrosine (Liothyronine Impurity) 3,5-Diiodo-L-tyrosine dihydrate, 10 mM in DMSO L-3, 5-diiodothyrosine (S)-2-AMino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid 300-39-0 C9H9I2NO3x2H2O C9H9I2NO3 C9H912NO3 C9H9I2NO32H2O Biochemicals and Reagents Amino Acids and Peptides BioChemical Modified Amino Acids