Glycylglycine
- CAS No.
- 556-50-3
- Chemical Name:
- Glycylglycine
- Synonyms
- GLY-GLY;H-GLY-GLY-OH;DIGLYCINE;GLY-GLY-OH;N-GLYCYLGLYCINE;2-(2-aMinoacetaMido)acetic acid;2-[(2-Aminoacetyl)amino]acetic acid;Glycylglycin;Gly2;y-GL
- CBNumber:
- CB3704259
- Molecular Formula:
- C4H8N2O3
- Molecular Weight:
- 132.12
- MDL Number:
- MFCD00008130
- MOL File:
- 556-50-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 220-240 °C (dec.) |
|---|---|
| Boiling point | 267.18°C (rough estimate) |
| Density | 1.5851 (rough estimate) |
| vapor pressure | 0.058Pa at 20-50℃ |
| refractive index | 1.4880 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| pka | 3.139(at 25℃) |
| form | Solid |
| color | White |
| PH | 4.5-6.0 (20℃, 1M in H2O) |
| PH Range | 7.5 - 8.9 |
| biological source | synthetic |
| Water Solubility | SOLUBLE IN HOT WATER |
| λmax |
λ: 260 nm Amax: 0.075 λ: 280 nm Amax: 0.072 |
| Merck | 14,4503 |
| BRN | 1765223 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Cosmetics Ingredients Functions |
HAIR CONDITIONING SKIN CONDITIONING |
| InChI | 1S/C4H8N2O3/c5-1-3(7)6-2-4(8)9/h1-2,5H2,(H,6,7)(H,8,9) |
| InChIKey | YMAWOPBAYDPSLA-UHFFFAOYSA-N |
| SMILES | NCC(=O)NCC(O)=O |
| LogP | -0.92 at 25℃ and pH6 |
| CAS DataBase Reference | 556-50-3(CAS DataBase Reference) |
| FDA UNII | 10525P22U0 |
| NIST Chemistry Reference | N-Glycylglycine(556-50-3) |
| EPA Substance Registry System | Glycylglycine (556-50-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.54 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P264-P280i-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36 | |||||||||
| Safety Statements | 24/25-26 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29241900 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Active | |||||||||
| NFPA 704 |
|
Glycylglycine price More Price(98)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PHR2733 | Diglycine (glycylglycine) Pharmaceutical Secondary Standard; Certified Reference Material | 556-50-3 | 200 mg | $198 | 2026-04-30 | Buy |
| Sigma-Aldrich | 50199 | Gly-Gly BioUltra, ≥99.5% (NT) | 556-50-3 | 10g | $90.6 | 2026-04-30 | Buy |
| Sigma-Aldrich | 50199 | Gly-Gly BioUltra, ≥99.5% (NT) | 556-50-3 | 50g | $344 | 2026-04-30 | Buy |
| TCI Chemical | G0124 | Glycylglycine >99.0%(T) | 556-50-3 | 25g | $41 | 2026-04-30 | Buy |
| TCI Chemical | G0124 | Glycylglycine >99.0%(T) | 556-50-3 | 100g | $124 | 2026-04-30 | Buy |
Glycylglycine Chemical Properties,Uses,Production
Chemical Properties
White crystals
Uses
Glycylglycine is as a buffering reagent and also used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. It is also employed as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C). Valuable agent for experiments investigating peptide transport and absorption.
Definition
ChEBI: A dipeptide formed from glycine residues.
Synthesis Reference(s)
Journal of the American Chemical Society, 75, p. 5323, 1953 DOI: 10.1021/ja01117a053
Biochem/physiol Actions
Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid. Diglycine is known to catalyze the formation of homo- and hetero dipeptides more efficiently than glycine.
Purification Methods
Crystallise glycylglycine from aqueous 50% EtOH or water at 50-60o by addition of EtOH. Dry it at 110o. It sublimes at 190-200o/0.3mm with 30% recovery [Gross & Gradsky J Am Chem Soc 77 1678 1955, King J Am Chem Soc 79 6153 1957]. [Beilstein 4 IV 2459.]
Glycylglycine Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chengdu Baishixing Science and Technology Industry Co.,Ltd | 18111554528 19544347486 | zhangyuchen@cd-bsx.com | China | 82 | 55 |
| Sichuan Tongsheng Amino acids Co.,Ltd. | 0838-2274206 17340404235 | sales@biots.cn | China | 300 | 66 |
| Shanghai Yikefan Biotechnology Co., LTD | 18221419461; 18221419461 | sales@yikefan.com | China | 612 | 58 |
| Gansu Province Baishixing Pharmaceutical Co.,Ltd | 15008395229 15008395229 | zhangqing@gs-bsx.com | China | 50 | 58 |
| SHANGHAI YUANJU BIO-TECH CO., LTD | 62750277 15618798178 | 362310313@qq.com | China | 469 | 58 |
| C N C H E M U N I O N C O . , L T D . | 17653471880 | david@cnchemunion.com | China | 109 | 58 |
| Guangdong Ymarl Biotechnology Co., Ltd. | 13482530519; 13482530519 | zhn2812@163.com | China | 33 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
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View Lastest Price from Glycylglycine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-12 | Glycylglycine
556-50-3
|
0.99 | RongNa Biotechnology Co.,Ltd | ||||
 |
2026-09-11 | Gly-Gly-OH
556-50-3
|
1kg | 98% | 1T+ | Sichuan HongRi Pharma-Tech Co.,Ltd | ||
 |
2026-09-11 | Glycylglycine
556-50-3
|
$800.00-999.00 | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD |
-
- Glycylglycine
556-50-3
- 0.99
- RongNa Biotechnology Co.,Ltd
-
- Gly-Gly-OH
556-50-3
- 98%
- Sichuan HongRi Pharma-Tech Co.,Ltd
-
- Glycylglycine
556-50-3
- $800.00-999.00
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
