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4-Methyl-2-(methylsulfanyl)pyrimidine

4-Methyl-2-(methylsulfanyl)pyrimidine Structure
4-Methyl-2-(methylsulfanyl)pyrimidine structure
CAS No.
14001-63-9
Chemical Name:
4-Methyl-2-(methylsulfanyl)pyrimidine
Synonyms
4-METHYL-2-(METHYLTHIO)PYRIMIDINE;SPECS AR-527/42979548;2-Methylthio-4-MethylpyriMidine;4-Methyl-2-Thiomethyl Pyrimidine;4-Methyl-2-(methylsulfanyl)pyrimidine;Pyrimidine, 4-methyl-2-(methylthio)-;4-Methyl-2-(Methylthio)pyriMidine 97%;4-Methyl-2-(methylsulphanyl)pyrimidine;4-Methyl-2-(methylthio)pyrimidine ,97%;Pyrimidine, 4-methyl-2-(methylthio)- (6CI, 8CI, 9CI)
CBNumber:
CB8324991
Molecular Formula:
C6H8N2S
Molecular Weight:
140.21
MDL Number:
MFCD00023242
MOL File:
14001-63-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 18:55:38
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4-Methyl-2-(methylsulfanyl)pyrimidine Properties

Boiling point 78-80°/1mm
Density 1.007 g/mL at 25 °C
refractive index n20/D 1.572
Flash point 220 °F
storage temp. 2-8°C
form liquid
pka 1.35±0.20(Predicted)
color Dark brown
InChI InChI=1S/C6H8N2S/c1-5-3-4-7-6(8-5)9-2/h3-4H,1-2H3
InChIKey UCERVHYBSTYCQS-UHFFFAOYSA-N
SMILES C1(SC)=NC=CC(C)=N1
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H315-H318-H335
Precautionary statements  P280-P301+P312+P330-P302+P352-P305+P351+P338+P310
target organs Respiratory system
PPE Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Hazard Codes  Xn
Risk Statements  22-37/38-41
Safety Statements  26-39
WGK Germany  3
HazardClass  IRRITANT
HS Code  29335990
Storage Class 10 - Combustible liquids
Hazard Classifications Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3
NFPA 704
1
2 0

4-Methyl-2-(methylsulfanyl)pyrimidine price More Price(34)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 674885 4-Methyl-2-(methylthio)pyrimidine 97% 14001-63-9 10g $95 2026-04-30 Buy
Apolloscientific OR60031 4-Methyl-2-(methylthio)pyrimidine >98% 14001-63-9 5g $21 2026-06-04 Buy
Apolloscientific OR60031 4-Methyl-2-(methylthio)pyrimidine >98% 14001-63-9 25g $71 2026-06-04 Buy
Apolloscientific OR60031 4-Methyl-2-(methylthio)pyrimidine >98% 14001-63-9 100g $262 2026-06-04 Buy
Apolloscientific OR60031 4-Methyl-2-(methylthio)pyrimidine >98% 14001-63-9 500g $1298 2026-06-04 Buy
Product number Packaging Price Buy
674885 10g $95 Buy
OR60031 5g $21 Buy
OR60031 25g $71 Buy
OR60031 100g $262 Buy
OR60031 500g $1298 Buy

4-Methyl-2-(methylsulfanyl)pyrimidine Chemical Properties, Uses, Production

Chemical Properties

Colorless to yellow to red liquid

Uses

4-Methyl-2-(methylthio)pyrimidine is used as a reagent to prepare pyrazolopyrimidines and pyrazolotriazines, both of which display potent activity against herpes viruses. 4-Methyl-2-(methylthio)pyrimidine is also used as a starting material to synthesize 4-substituted-2-aminopyrimidines (e.g. 2-amino-4-ethylpyridine [A609500]), novel c-Jun N-terminal kinase (JNK) inhibitors.

Synthesis

To an aqueous (120 mL) solution of NaOH (7.46 g, 186.4 mmol) under argon atmosphere, 4-methylpyrimidine-2-thiolate (13.78 g, 84.7 mmol) was added, followed by the dropwise addition of into iodomethane (13.23 g, 93.2 mmol). The solution was stirred at room temperature for 2 hours and then CH2Cl2(2x) was used to Extraction. The organic phase was dried over Na2SO4 and concentrated to dryness. The crude product obtained was purified by silica gel chromatography using a hexane-EtOAc mixture of increased polarity as eluent to yield 10.26 g of the desired compound (yield: 86%).

4-Methyl-2-(methylsulfanyl)pyrimidine Preparation Products And Raw materials

Raw materials

Ethanol Acetylacetaldehyde dimethyl acetal Hydrochloric acid Iodomethane Thiourea

Preparation Products

2(1H)-Pyrimidinone, 4-methyl-, hydrazone (9CI) 2-[2-(Methylsulfanyl)-4-pyrimidinyl]-1-[3-(trifluoromethyl)phenyl]-1-ethanone 2-[2-(Methylthio)pyrimidin-4-yl]-1-[1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]ethanone 2-(2-(methylthio)pyrimidin-4-yl)-3-oxopropanenitrile

4-Methyl-2-(methylsulfanyl)pyrimidine Suppliers

Global Suppliers ( 166)
Supplier Tel Email Country ProdList Advantage
Jinan Xinzheng Pharmaceutical Technology Co., Ltd. 0531-88798968 18615218958 yin3684895@126.com China 185 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Jia Xing Isenchem Co.,Ltd 0573-85285100 18627885956 isenchem@163.com China 9389 66
Pure Chemistry Scientific Inc. 001-857-928-2050 or 1-888-588-9418 sales@chemreagents.com United States 10174 62
Shanghai Longsheng chemical Co.,Ltd. 58099637 13585536065 sales@shlschem.com China 9880 59
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696 info@hanhongsci.com China 42917 64
Shandong Xiya Chemical Co., Ltd 13355009207 13355009207 3007715519@qq.com China 18722 57
Supplier Advantage
Jinan Xinzheng Pharmaceutical Technology Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Alfa Aesar 84
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56
Jia Xing Isenchem Co.,Ltd 66
Pure Chemistry Scientific Inc. 62
Shanghai Longsheng chemical Co.,Ltd. 59
Shanghai Hanhong Scientific Co.,Ltd. 64
Shandong Xiya Chemical Co., Ltd 57

View Latest Price from 4-Methyl-2-(methylsulfanyl)pyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-METHYL-2-(METHYLSULFANYL)PYRIMIDINE pictures 2026-08-20 4-METHYL-2-(METHYLSULFANYL)PYRIMIDINE
14001-63-9
 $1.10 1g 99.00% 100 Tons Min Dideu Industries Group Limited
2-methylthio-4-methylpyrimidine pictures 2025-05-23 2-methylthio-4-methylpyrimidine
14001-63-9
 $150.00 1kg 99% 500kg Hebei Zhuanglai Chemical Trading Co Ltd
4-METHYL-2-(METHYLSULFANYL)PYRIMIDINE pictures 2019-07-06 4-METHYL-2-(METHYLSULFANYL)PYRIMIDINE
14001-63-9
 $1.00 1kg 98% 100KG Career Henan Chemical Co

4-Methyl-2-(methylsulfanyl)pyrimidine Spectrum

4-METHYL-2-(METHYLSULFANYL)PYRIMIDINE(14001-63-9)1HNMR

14001-63-9 (4-Methyl-2-(methylsulfanyl)pyrimidine) Related Search:

4-(Dimethoxymethyl)-2-(methylthio)-pyrimidine 4-METHOXY-6-METHYL-2-METHYLSULFANYL-PYRIMIDINE 4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97% 4,6-Dimethyl-2-methylmercapyrimidine 4-Chloro-6-methyl-2-(methylthio)pyrimidine
5-Methyl-2-methylsulfanyl-pyrimidine 2-Chloro-4-methyl-6-methylsulfanyl-pyrimidine 4-Chloro-5-methyl-2-methylsulfanyl-pyrimidine 4-Methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester ,98% Ethyl 4-(trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylate ,97%
5-Methyl-2-(methylthio)pyrimidine ,98% 1-(4-Methyl-2-(methylthio)pyrimidin-5-yl)ethanone ,97% ethyl 4-methyl-2-(methylsulfanyl)pyrimidine-5-carboxylate 5,5-diethyl-3-methyl-6-methylsulfanyl-pyrimidine-2,4-dione 4,6-dichloro-5-({4-[(2-methylpropyl)oxy]phenyl}methyl)-2-(methylsulfanyl)pyrimidine
4-Methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester 4-Chloro-6-methyl-2-methylsulfanyl-pyrimidine-5-carboxylic acid ethyl ester 4-Chloro-5-(2-chloroethyl)-6-methyl-2-(methylsulfanyl)pyrimidine

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4-Methyl-2-Thiomethyl Pyrimidine Pyrimidine, 4-methyl-2-(methylthio)- (6CI, 8CI, 9CI) SPECS AR-527/42979548 4-Methyl-2-(methylthio)pyrimidine ,97% Pyrimidine, 4-methyl-2-(methylthio)- 4-Methyl-2-(methylsulphanyl)pyrimidine 2-Methylthio-4-MethylpyriMidine 4-Methyl-2-(Methylthio)pyriMidine 97% 4-METHYL-2-(METHYLSULFANYL)PYRIMIDINE ISO 9001：2015 REACH 4-METHYL-2-(METHYLTHIO)PYRIMIDINE 4-Methyl-2-(methylsulfanyl)pyrimidine 14001-63-9 Heterocyclic Building Blocks Pyrimidines Building Blocks Heterocycle-Pyrimidine series PYRIMIDINE THIOL Building Blocks Heterocyclic Building Blocks Pyrimidines