PNU 37883 hydrochloride
- CAS No.
- 57568-80-6
- Chemical Name:
- PNU 37883 hydrochloride
- Synonyms
- U-37883A;PNU 37883 HCl;PNU 37883 hydrochlor;PNU 37883 HYDROCHLORIDE;U-37883A, ATP-sensitive K+ channel blocker;N-CYCLOHEXYL-N'-TRICYCLO[3.3.1.1(3,7)]DEC-1-YL-4-MORPHOLINECARBOXIMIDAMIDE HYDROCHLORIDE
- CBNumber:
- CB3714151
- Molecular Formula:
- C21H36ClN3O
- Molecular Weight:
- 381.98
- MDL Number:
- MFCD03840615
- MOL File:
- 57568-80-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
PNU 37883 hydrochloride price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 44821 | PNU 37883 (hydrochloride) ≥98% | 57568-80-6 | 1mg | $35 | 2026-04-30 | Buy |
| Cayman Chemical | 44821 | PNU 37883 (hydrochloride) ≥98% | 57568-80-6 | 5mg | $166 | 2026-04-30 | Buy |
| Cayman Chemical | 44821 | PNU 37883 (hydrochloride) ≥98% | 57568-80-6 | 10mg | $210 | 2026-04-30 | Buy |
| Usbiological | 256296 | PNU 37883 hydrochloride Asreported | 57568-80-6 | 10mg | $423 | 2026-06-03 | Buy |
| Usbiological | 256296 | PNU 37883 hydrochloride Asreported | 57568-80-6 | 50mg | $1103 | 2026-06-03 | Buy |
PNU 37883 hydrochloride Chemical Properties, Uses, Production
Uses
PNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2].
Biological Activity
Novel antagonist selective for the vascular form of K ATP channel; inhibits K ATP currents in isolated mesenteric artery smooth muscle cells (K d = 65 nM) but not in cardiac or skeletal myocytes. In vivo, inhibits blood vessel relaxation and hypotension induced by pinacidil. Displays weak diuretic effects.
storage
room temperature (desiccate)
References
[1] Yi Cui, et al. Different molecular sites of action for the KATP channel inhibitors, PNU-99963 and PNU-37883A. Br J Pharmacol. 2003 May;139(1):122-8. DOI:10.1038/sj.bjp.0705228
[2] Noriyoshi Teramoto. Pharmacological Profile of U-37883A, a Channel Blocker of Smooth Muscle-Type ATP-Sensitive K Channels. Cardiovasc Drug Rev. Spring 2006;24(1):25-32. DOI:10.1111/j.1527-3466.2006.00025.x
[3] Guang-Yuan Mar, et al. Changes of imidazoline receptors in spontaneously hypertensive rats. Int J Exp Pathol. 2013 Feb;94(1):17-24. DOI:10.1111/iep.12000
PNU 37883 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
PNU 37883 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 9792 | 55 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| Jinan Jiuli Biotechnology Co. , Ltd. | 15865264761 | 486064515@qq.com | China | 4999 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 15921930842 15921930842 | yh-wang@univ-bio.com | China | 25030 | 58 |
View Latest Price from PNU 37883 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | PNU 37883 hydrochloride
57568-80-6
|
$217.00-2500.00 | 10g | TargetMol Chemicals Inc. |
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- PNU 37883 hydrochloride
57568-80-6
- $217.00-2500.00
- TargetMol Chemicals Inc.
