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2-Bromo-5-nitrobenzotrifluoride

2-Bromo-5-nitrobenzotrifluoride Structure
2-Bromo-5-nitrobenzotrifluoride structure
CAS No.
367-67-9
Chemical Name:
2-Bromo-5-nitrobenzotrifluoride
Synonyms
2-Bromo-5-nitrobenzo;Alvocidib Impurity 32;LABOTEST-BB LT01143236;Bicalutamide Impurity 5;Bicalutamide Impurity 3;Bicalutamide Impurity 10;Bicalutamide Impurity 20;2-Bromo-5-nitrobenzotrifluorid;2-broMo-5-nitrotrifluorotoluol;2-Bromo-5-nitrobenzotrifluride
CBNumber:
CB3721603
Molecular Formula:
C7H3BrF3NO2
Molecular Weight:
270
MDL Number:
MFCD00014707
MOL File:
367-67-9.mol
MSDS File:
SDS
Last updated:2026-05-28 04:52:39
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2-Bromo-5-nitrobenzotrifluoride Properties

Melting point 41-44 °C (lit.)
Boiling point 87-88 °C/3 mmHg (lit.)
Density 1.7750 (estimate)
Flash point >230 °F
storage temp. Sealed in dry,Room Temperature
solubility soluble in Methanol
form powder to crystal
color White to Light yellow to Green
BRN 2460260
Exposure limits ACGIH: TWA 2.5 mg/m3
NIOSH: IDLH 250 mg/m3
InChI InChI=1S/C7H3BrF3NO2/c8-6-2-1-4(12(13)14)3-5(6)7(9,10)11/h1-3H
InChIKey SXEQQBBOAMHOID-UHFFFAOYSA-N
SMILES C1(Br)=CC=C([N+]([O-])=O)C=C1C(F)(F)F
CAS DataBase Reference 367-67-9(CAS DataBase Reference)
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H302-H312-H332-H335
Precautionary statements  P280h-P305+P351+P338-P337+P313-P261-P264-P270-P271-P280-P301+P312+P330-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P501
PPE Eyeshields, Gloves, type N95 (US)
Hazard Codes  Xi,Xn
Risk Statements  36/37/38-20/21/22
Safety Statements  37/39-26-24/25
RIDADR  2306
WGK Germany  3
HazardClass  IRRITANT
HS Code  29049090
Storage Class 11 - Combustible Solids
NFPA 704
1
2 0

2-Bromo-5-nitrobenzotrifluoride price More Price(54)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 365769 2-Bromo-5-nitrobenzotrifluoride 97% 367-67-9 5g $31.2 2023-06-20 Buy
TCI Chemical B3686 2-Bromo-5-nitrobenzotrifluoride >98.0%(GC) 367-67-9 5g $27 2026-04-30 Buy
TCI Chemical B3686 2-Bromo-5-nitrobenzotrifluoride >98.0%(GC) 367-67-9 25g $107 2026-04-30 Buy
Usbiological 264248 2-Bromo-5-nitrobenzotrifluoride Asreported 367-67-9 100g $380 2026-06-03 Buy
Apolloscientific PC1490 2-Bromo-5-nitrobenzotrifluoride 98% 367-67-9 25g $21 2026-06-04 Buy
Product number Packaging Price Buy
365769 5g $31.2 Buy
B3686 5g $27 Buy
B3686 25g $107 Buy
264248 100g $380 Buy
PC1490 25g $21 Buy

2-Bromo-5-nitrobenzotrifluoride Chemical Properties,Uses,Production

Chemical Properties

yellow crystals

Uses

2-Bromo-5-nitrobenzotrifluoride may be used in the preparation of:

  • new unsymmetrical diamine monomer containing both the benzimidazole ring and trifluoromethyl group, 6,4′-diamino-2′-trifluoromethyl-2-phenylbenzimidazole
  • 2,5-bis[(4-nitro-2-trifluoromethylphenoxy)-phenyl]diphenylphosphine oxide (BNTFDPO)

Synthesis

2-Bromobenzotrifluoride

392-83-6

2-Bromo-5-nitrobenzotrifluoride

367-67-9

General procedure for the synthesis of 2-bromo-5-nitrobenzotrifluoride from o-bromobenzotrifluoride: 260 g of concentrated sulfuric acid (98%) was placed in a reaction flask at room temperature, and 120 g of fuming nitric acid was added slowly to prepare a nitrification acid mixture. The temperature of the reaction system was maintained at 50-60°C, and 390g of o-bromobenzotrifluoride was slowly added to the mixed acid. After the addition was completed, the temperature was maintained and the reaction continued to be stirred until the GC test showed that the raw material was completely consumed and the reaction was completed. After the reaction solution was left to stratify, the upper organic phase was separated and washed to neutrality with alkali. A bright yellow liquid was obtained, which was immediately post-treated to finally obtain 450.4 g of 2-bromo-5-nitrobenzotrifluoride, with a GC purity of 95% and a yield of 92%.

References

[1] Patent: CN106905104, 2017, A. Location in patent: Paragraph 0020-0021
[2] Journal of the American Chemical Society, 1951, vol. 73, p. 3932

2-Bromo-5-nitrobenzotrifluoride synthesis

392-83-6
367-67-9
Synthesis of 2-Bromo-5-nitrobenzotrifluoride from 2-Bromobenzotrifluoride

2-Bromo-5-nitrobenzotrifluoride Preparation Products And Raw materials

Raw materials

2-Bromobenzotrifluoride

Preparation Products

4-Bromo-3-(trifluoromethyl)aniline 4-Nitro-2-(trifluoromethyl)benzoyl chloride

2-Bromo-5-nitrobenzotrifluoride Suppliers

Global( 401)Suppliers
Supplier Tel Email Country ProdList Advantage
Changzhou Chemscaler Pharmtech Co., Ltd. 0519-81096292 15312577869 chemscaler@yahoo.com.cn China 300 60
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Ark Pharm, Inc. 847-367-3680 sales@arkpharminc.com United States 1669 56
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44850 61
Wuhan Chemwish Technology Co., Ltd 86-027-67849912 sales@chemwish.com China 35884 56
Supplier Advantage
Changzhou Chemscaler Pharmtech Co., Ltd. 60
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
ShangHai DEMO Chemical Co.,Ltd 57
Ark Pharm, Inc. 56
Energy Chemical 61
Wuhan Chemwish Technology Co., Ltd 56

View Lastest Price from 2-Bromo-5-nitrobenzotrifluoride manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Bromo-5-nitrobenzotrifluoride pictures 2026-09-02 2-Bromo-5-nitrobenzotrifluoride
367-67-9
 $8.00 1KG 99% Henan Fengda Chemical Co., Ltd
2-Bromo-5-nitrobenzotrifluoride pictures 2026-06-30 2-Bromo-5-nitrobenzotrifluoride
367-67-9
 1KG 99.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd
2-Bromo-5-nitrobenzotrifluoride pictures 2026-02-02 2-Bromo-5-nitrobenzotrifluoride
367-67-9
 50mg 99%HPLC 2000tons Shaanxi Dideu Medichem Co. Ltd

2-Bromo-5-nitrobenzotrifluoride Spectrum

2-Bromo-5-nitrobenzotrifluoride(367-67-9)1HNMR2-Bromo-5-nitrobenzotrifluoride(367-67-9)Raman2-Bromo-5-nitrobenzotrifluoride(367-67-9)IR

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2-BROMO-5-NITROBENZOTRIFLUORIDE 2-BROMO-5-NITRO-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE 5-NITRO-2-BROMOBENZOTRIFLUORIDE LABOTEST-BB LT01143236 2-Bromo-5-nitrobenzotrifluorid 1-bromo-4-nitro-2-(trifluoromethyl)benzene 2-Bromo-5-nitrobenzotrifluoride98% 3-Trifluoromethyl-4-bromonitrobenzene Bicalutamide Impurity 10 2-BroMo-alpha,alpha,alpha-trifluoro-5-nitrotoluene 4-BroMo-3-(trifluoroMethyl)nitrobenzene 1-bromo-4-nitro-2-(trifluoromethyl)benzen 2-Bromo-5-nirtobenzotrifluoride 2-Bromo-5-nitrobenzo 2-BroMo-5-nitro trifluoroMethyl 2-broMo-5-nitrotrifluorotoluol 2-bromo-5-nitrotrifluorotoluene 2-trifluoromethyl-4-nitrobromobenzene Benzene,1-broMo-4-nitro-2-(trifluoroMethyl)- 2-Bromo-5-nitrobenzotrifluride 2-Bromo-5-nitrobenzotrifluoride > Bicalutamide Impurity 5 Bicalutamide Impurity 3 Bicalutamide Impurity 20 (2RS)-N-[4-Bromo-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)-sulfonyl]-2-hydroxy-2-methylpropanamide Alvocidib Impurity 32 (2RS)-N-[4-Bromo-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)-sulfonyl]-2-hydroxy-2-methylpropanam 2-Bromo-5-nitrobenzotrifluoride, 96% 2-bromo-5-aminotrifluorotoluene 367-67-9 Building Blocks Nitrogen Compounds Organic Building Blocks Nitro Compounds ARYL HALIDE Nitro Compounds Nitrogen Compounds Organic Building Blocks Benzene series API intermediates Trifluoromethylbenzene serise