3',5'-Difluoro-2'-hydroxyacetophenone
- CAS No.
- 140675-42-9
- Chemical Name:
- 3',5'-Difluoro-2'-hydroxyacetophenone
- Synonyms
- 1-(3,5-DIFLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE;1-(3,5-Difluoro-2-hydroxyphenyl)ethanone;3,5-DIFLUOROSALICYLALDEHYDE;3,5-DIFLUORO-2-HYDROXYACETOPHENONE;3',5'-Difluoro-2'-hydroxyacetophenone;3',5'-Difluoro-2'-hydroxyacetophenone98%;3',5'-Difluoro-2'-hydroxyacetophenone 98%;3',5'-Difluoro-2'-hydroxyacetophenone,97%;Ethanone, 1-(3,5-difluoro-2-hydroxyphenyl)-;1-(3,5-Difluoro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-4,6-difluorophenol
- CBNumber:
- CB3725595
- Molecular Formula:
- C8H6F2O2
- Molecular Weight:
- 172.13
- MDL Number:
- MFCD00042476
- MOL File:
- 140675-42-9.mol
- MSDS File:
- SDS
| Melting point | 53-55°C |
|---|---|
| Boiling point | 220.8±35.0 °C(Predicted) |
| Density | 1.346±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| form | powder |
| pka | 8.93±0.23(Predicted) |
| color | Khaki/gold |
| CAS DataBase Reference | 140675-42-9(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P280g-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| Hazard Note | Irritant | |||||||||
| HS Code | 2914500090 | |||||||||
| NFPA 704 |
|
3',5'-Difluoro-2'-hydroxyacetophenone price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Apolloscientific | PC2826 | 3',5'-Difluoro-2'-hydroxyacetophenone 98% | 140675-42-9 | 1g | $21 | 2026-06-04 | Buy |
| Activate Scientific | AS113383 | 1-(3,5-Difluoro-2-hydroxyphenyl)ethanone 98% | 140675-42-9 | 1g | $20 | 2026-06-04 | Buy |
| Activate Scientific | AS113383 | 1-(3,5-Difluoro-2-hydroxyphenyl)ethanone 98% | 140675-42-9 | 5g | $67 | 2026-06-04 | Buy |
| Activate Scientific | AS113383 | 1-(3,5-Difluoro-2-hydroxyphenyl)ethanone 98% | 140675-42-9 | 25g | $193 | 2026-06-04 | Buy |
| Matrix Scientific | 004372 | 3',5'-Difluoro-2'-hydroxyacetophenone | 140675-42-9 | 10.00g | $57 | 2026-05-18 | Buy |
3',5'-Difluoro-2'-hydroxyacetophenone Chemical Properties, Uses, Production
Preparation
This compound can be easily obtained by Fries rearrangement of 2,4-difluorophenyl acetate with aluminium chloride without solvent at 150°, and purified by recrystallization from ethanol (80–90%) ; the 2,4-difluorophenyl acetate is prepared by reaction of acetic anhydride on 2,4-difluorophenol.
Synthesis
36914-77-9
140675-42-9
General procedure for the synthesis of 1-(3,5-difluoro-2-hydroxyphenyl)ethanone from 2,4-difluorophenyl acetate: a mixture of intermediate 362 (2 g, 11.6 mmol) and aluminum trichloride (2.8 g) was heated under argon protection at 150 °C for 30 min. After completion of the reaction, it was cooled to room temperature and ice water was added cautiously followed by dropwise addition of 1N aqueous hydrochloric acid solution. The mixture was decanted in the presence of toluene and the organic phase was separated and washed sequentially with water and saturated aqueous sodium chloride. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the solid product intermediate 363 (1.5 g). The product was characterized as follows: 1H NMR (300 MHz, CDCl3): δ 12.00 (m, 1H), 7.25 (m, 1H), 7.10 (m, 1H), 2.65 (s, 3H). ir (cm-1): 1651.
References
[1] Journal of Medicinal Chemistry, 2006, vol. 49, # 22, p. 6569 - 6584
[2] Patent: US2017/137385, 2017, A1. Location in patent: Paragraph 0279; 0283; 0284; 0285
[3] Patent: US6191164, 2001, B1
3',5'-Difluoro-2'-hydroxyacetophenone Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Changzhou Huanling Chemical Co., Ltd. | 89803005 18206112582 | info@huanlingchem.com | China | 983 | 68 |
| Adamas Reagent, Ltd. | 400-6009262 15618770481 | yhx@titansci.com | China | 14098 | 59 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 | sales@sun-shinechem.com | China | 1197 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
View Latest Price from 3',5'-Difluoro-2'-hydroxyacetophenone manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-15 | 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE
140675-42-9
|
$1.00 | 1KG | 99.0% | 100kg | Career Henan Chemical Co |
-
- 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE
140675-42-9
- $1.00
- 99.0%
- Career Henan Chemical Co
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