3-(2-Bromophenyl)propionic acid

Synthesis

The target compound 3-(2-bromophenyl)propionic acid was prepared from 3-phenylpropionic acid as the starting material via an aromatic ring bromination reaction, or from diethyl malonate and 2-bromobenzyl bromide as the starting materials via a substitution reaction. The synthetic reaction formula is shown in the figure below:

Figure 3-(2-bromophenyl)propionic acid

Uses

3-(2-bromophenyl)propionic acid is an inexpensive and readily available raw material. The structure of the raw material itself is very similar to that of phenyllactic acid. If a hydroxyl group can be introduced at the α-position of its carboxylic acid branch, this would be a simple method for synthesizing tanshinone derivatives.

Chemical Properties

White solid

General Description

3-(2-Bromophenyl)propionic acid is an important compound used as a pharmaceutical intermediate. It can be employed in the synthesis of compounds that reverse PD-1 resistance or macrolide compounds (MC4R agonists). The bromine atom and carboxyl group in its structure are key to the compound's high reactivity, facilitating the synthesis of other, more complex active molecules.

Hazard

3-(2-Bromophenyl)propionic acid is harmful if swallowed. Contact may cause skin irritation and severe eye irritation. Inhalation may cause respiratory irritation.