2-Aminobenzothiazole-6-carboxylic acid
- CAS No.
- 93-85-6
- Chemical Name:
- 2-Aminobenzothiazole-6-carboxylic acid
- Synonyms
- AKOS BB-7723;ASISCHEM B67429;AKOS BBS-00000327;SALOR-INT L481106-1EA;2-Aminobenzothiazolepurum;forspectrophotometricdet.(ofPd);2-Aminobenzothiazol-6-carbonsure;forgravimetricdetermination(ofHg);2-AMINO-6-BENZOTHIAZOLECARBOXYLIC ACID;2-AMINO-BENZOTHIAZOLE-6-CARBOXYLIC ACID
- CBNumber:
- CB3780886
- Molecular Formula:
- C8H6N2O2S
- Molecular Weight:
- 194.21
- MDL Number:
- MFCD00054180
- MOL File:
- 93-85-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 265 ºC (DEC.) |
|---|---|
| Boiling point | 466.6±37.0 °C(Predicted) |
| Density | 1.604 |
| storage temp. | 2-8°C(protect from light) |
| form | solid |
| pka | 3.99±0.30(Predicted) |
| color | Off-white |
| CAS DataBase Reference | 93-85-6(CAS DataBase Reference) |
| EPA Substance Registry System | 6-Benzothiazolecarboxylic acid, 2-amino- (93-85-6) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-37 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29342000 | |||||||||
| NFPA 704 |
|
2-Aminobenzothiazole-6-carboxylic acid price More Price(68)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | L481106 | 2-AMINO-1,3-BENZOTHIAZOLE-6-CARBOXYLIC ACID AldrichCPR | 93-85-6 | 1 unit | $197 | 2026-04-30 | Buy |
| Sigma-Aldrich | L481106 | 2-AMINO-1,3-BENZOTHIAZOLE-6-CARBOXYLIC ACID Aldrich | 93-85-6 | 250mg | $179 | 2024-03-01 | Buy |
| Apolloscientific | OR15130 | 2-Amino-1,3-benzothiazole-6-carboxylic acid ≥95% | 93-85-6 | 5g | $55 | 2026-06-04 | Buy |
| Matrix Scientific | 027026 | 2-Amino-1,3-benzothiazole-6-carboxylic acid | 93-85-6 | 10.00g | $59 | 2026-05-18 | Buy |
| Matrix Scientific | 027026 | 2-Amino-1,3-benzothiazole-6-carboxylic acid | 93-85-6 | 25.00g | $107 | 2026-05-18 | Buy |
2-Aminobenzothiazole-6-carboxylic acid Chemical Properties, Uses, Production
Uses
2-Aminobenzothiazole-6-carboxylic acid is a heterocyclic organic compound that can be used as an organic intermediate. 2-Aminobenzothiazoles belong to a class of heterocyclic compounds with diverse biological activities. For example, riluzole, clinically used to treat amyotrophic lateral sclerosis (ALS), belongs to the 2-aminobenzothiazole class; fulenteazole has antiviral, anthelmintic, and immunosuppressive activities; N-acyl-substituted 2-aminobenzothiazoles can inhibit HIV; and N-aryl-substituted 2-aminobenzothiazoles have strong anticancer activity. 2-Aminobenzothiazoles are also widely used in the development of antibacterial, antiviral, and anti-inflammatory drugs for the treatment of Parkinson's disease and diabetes. Therefore, 2-aminobenzothiazoles occupy a very important position in medicinal chemistry.
Chemical Properties
Light brown powder
Antimicrobial activity
2-Aminobenzothiazole-6-carboxylic acid is a synthetic antibacterial agent that inhibits bacterial growth by binding to the enzyme urokinase-type plasminogen (uPA) and preventing it from converting plasminogen to plasmin. This drug has been shown to have inhibitory properties against a wide range of bacteria, including Staphylococcus and Escherichia coli.
Synthesis
540-72-7
150-13-0
93-85-6
Steps for the synthesis of 2-aminobenzothiazole-6-carboxylic acid: (2) Sodium thiocyanate (NaSCN, 65 g, 0.8 mol) was added to a methanol (MeOH) suspension of 4-aminobenzoic acid (1,100 g, 0.73 mol), followed by batch addition of bromine (Br2, 38 mL, 0.73 mol). The reaction mixture was cooled to -10 °C and stirred for 2 hours while keeping the internal temperature below -5 °C. Upon completion of the reaction, the precipitate was collected by filtration and suspended in 350 ml of 1 M hydrochloric acid (HCl). The suspension was heated to reflux and maintained for 30 minutes. After rapid filtration, 150 ml of concentrated hydrochloric acid (HCl) was added to the hot filtrate to give 70 g (42% yield) of 2-aminobenzothiazole-6-carboxylic acid (white solid). The product was dried and used directly without further purification.
References
[1] Patent: US2009/123373, 2009, A1. Location in patent: Page/Page column 14-15
2-Aminobenzothiazole-6-carboxylic acid Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Shijiazhuang Sdyano Fine Chemical Co., Ltd. | 0311-89250318 13582355795 | master@sjzsdyn.com | China | 2776 | 65 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. | 21-57721279 18121011378 | sales@shydchem.com.cn | China | 998 | 56 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Tianjin heowns Biochemical Technology Co., Ltd. | 400 638 7771 | sales@heowns.com | China | 14412 | 57 |
View Latest Price from 2-Aminobenzothiazole-6-carboxylic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-02 | 2-Aminobenzothiazole-6-carboxylic acid
93-85-6
|
$1.50-36.00 | 1kg | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-12-24 | 2-Aminobenzothiazole-6-carboxylic acid
93-85-6
|
1KG | 99.0% | 1000KG | Shaanxi Dideu Medichem Co. Ltd | ||
 |
2022-01-15 | 2-Aminobenzothiazole-6-CarboxylicAcid
93-85-6
|
1KG | 97.5% | 100 tons | Honest Joy Holdings Limited |
-
- 2-Aminobenzothiazole-6-carboxylic acid
93-85-6
- $1.50-36.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Aminobenzothiazole-6-carboxylic acid
93-85-6
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
-
- 2-Aminobenzothiazole-6-CarboxylicAcid
93-85-6
- $0.00
- 97.5%
- Honest Joy Holdings Limited
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