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ChemicalBook >> CAS DataBase List >>3-(1-Piperazinyl)-1,2-benzisothiazole

3-(1-Piperazinyl)-1,2-benzisothiazole

3-(1-Piperazinyl)-1,2-benzisothiazole Structure
3-(1-Piperazinyl)-1,2-benzisothiazole structure
CAS No.
87691-87-0
Chemical Name:
3-(1-Piperazinyl)-1,2-benzisothiazole
Synonyms
3-Piperazinyl-1,2-benzisothiazole (PRB);4-(1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINE;lurasidone-1;AKOS B030093;3-Piperazinyl-1;Lurasidone INT 2;2-benzisothiazole;Lurasidone Impurity 13;Lurasidone BIP Impurity;Antidepressant agent 10
CBNumber:
CB3783377
Molecular Formula:
C11H13N3S
Molecular Weight:
219.31
MDL Number:
MFCD04117970
MOL File:
87691-87-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-05-28 02:02:40
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3-(1-Piperazinyl)-1,2-benzisothiazole Properties

Melting point 89.0 to 93.0 °C
Boiling point 320.2±35.0 °C(Predicted)
Density 1.256
storage temp. 2-8°C
solubility soluble in Methanol
pka 8.52±0.10(Predicted)
form powder to crystal
color White to Light yellow
BRN 4253627
InChI InChI=1S/C11H13N3S/c1-2-4-10-9(3-1)11(13-15-10)14-7-5-12-6-8-14/h1-4,12H,5-8H2
InChIKey KRDOFMHJLWKXIU-UHFFFAOYSA-N
SMILES S1C2=C(C=CC=C2)C(N2CCNCC2)=N1
LogP 2.14
CAS DataBase Reference 87691-87-0(CAS DataBase Reference)
FDA UNII 59D8RAT1F9
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Skull and Crossbones (GHS06)
GHS06
Signal word  Danger
Hazard statements  H301-H315-H319
Precautionary statements  P301+P310+P330-P302+P352-P305+P351+P338
Hazard Codes  Xi,T
Risk Statements  25-36/38
Safety Statements  26-45
RIDADR  UN 2811 6.1 / PGIII
WGK Germany  3
HazardClass  IRRITANT
HS Code  29349990
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
REACH Registrations Active
NFPA 704
0
1 0

3-(1-Piperazinyl)-1,2-benzisothiazole price More Price(66)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 728519 3-(1-Piperazinyl)-1,2-benzisothiazole ≥98% (HPLC) 87691-87-0 5g $149 2026-04-30 Buy
Sigma-Aldrich 728519 3-(1-Piperazinyl)-1,2-benzisothiazole ≥98% (HPLC) 87691-87-0 1g $57.5 2023-06-20 Buy
TCI Chemical P2064 3-(1-Piperazinyl)-1,2-benzisothiazole >98.0%(GC)(T) 87691-87-0 1g $60 2026-04-30 Buy
TCI Chemical P2064 3-(1-Piperazinyl)-1,2-benzisothiazole >98.0%(GC)(T) 87691-87-0 5g $176 2026-04-30 Buy
TRC TRC-P480600-5G 3-(1-Piperazinyl)-1,2-benzisothiazole 87691-87-0 5g $129 2026-06-03 Buy
Product number Packaging Price Buy
728519 5g $149 Buy
728519 1g $57.5 Buy
P2064 1g $60 Buy
P2064 5g $176 Buy
TRC-P480600-5G 5g $129 Buy

3-(1-Piperazinyl)-1,2-benzisothiazole Chemical Properties,Uses,Production

Chemical Properties

3-(1-Piperazinyl)-1,2-benzisothiazole is Yellow Solid

Uses

3-(1-Piperazinyl)-1,2-benzisothiazole is a reagent used to synthesize Ziprasidione

Definition

ChEBI: ID11614 is a N-arylpiperazine.

IC 50

5-HT1A Receptor: 190 nM (IC50); 5-HT2 Receptor: 110 nM (IC50)

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 23, p. 6552 - 6563
[2] Patent: CN108440520, 2018, A. Location in patent: Paragraph 0054; 0056; 0062; 0063
[3] Journal of Medicinal Chemistry, 1986, vol. 29, # 3, p. 359 - 369
[4] Patent: WO2010/38948, 2010, A2. Location in patent: Page/Page column 54-55
[5] Chemical and Pharmaceutical Bulletin, 1995, vol. 43, # 12, p. 2139 - 2151

3-(1-Piperazinyl)-1,2-benzisothiazole synthesis

110-85-0
7716-66-7
87691-87-0
Synthesis of 3-(1-Piperazinyl)-1,2-benzisothiazole from Piperazine and 3-Chloro-1,2-benzisothiazole

3-(1-Piperazinyl)-1,2-benzisothiazole Preparation Products And Raw materials

Raw materials

Ethanol, 2,2'-(1,2-benzisothiazol-3-ylimino)bis- Benzoyl chloride, 2-(chlorothio)- (9CI) 3-Chloro-1,2-benzisothiazole 1,2-Benzisothiazol-3(2H)-one 2,2'-dithiodibenzoyl chloride
2,2'-Dithiosalicylic acid Piperazine 3-Piperazinyl-1,2-benzisothiazole hydrochloride 2-Chlorobenzonitrile

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Preparation Products

PEROSPIRONE

3-(1-Piperazinyl)-1,2-benzisothiazole Suppliers

Global( 478)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Million Pharmaceutical Co., Ltd 0531-68659554 13031714605 3299907431@qq.com China 80 58
Shanghai Qiao Chemical Science Co., Ltd 021-58892003 info@qiaochem.com China 6065 65
Jinan Jianfeng Chemical Co., Ltd. 0531-88110457; 18954159893 demi@pharmachemm.com China 205 58
Shanghai Witofly Chemical Co. ,Ltd. 02150630626 17717886015 sales@witofly.com China 1864 55
Jinan Billion Pharmaceutical Technology Co., Ltd +86-15589952515 80912934@qq.com China 57 58
Huaian Jiamu Biotechnology Co., Ltd. 0517-83187139 18205232085 cai@jiamu-bio.com China 2999 58
Anhui Sun-wise Pharmaceutical Co., Ltd. 18856027890 18856027890 83618010@qq.com China 53 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
Jinan Million Pharmaceutical Co., Ltd 58
Shanghai Qiao Chemical Science Co., Ltd 65
Jinan Jianfeng Chemical Co., Ltd. 58
Shanghai Witofly Chemical Co. ,Ltd. 55
Jinan Billion Pharmaceutical Technology Co., Ltd 58
Huaian Jiamu Biotechnology Co., Ltd. 58
Anhui Sun-wise Pharmaceutical Co., Ltd. 58
J & K SCIENTIFIC LTD. 76
Chembest Research Laboratories Limited 61
TCI (Shanghai) Development Co., Ltd. 81

View Lastest Price from 3-(1-Piperazinyl)-1,2-benzisothiazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
3-(1-Piperazinyl)-1,2-benzisothiazole pictures 2026-09-11 3-(1-Piperazinyl)-1,2-benzisothiazole
87691-87-0
 $2.00 1kg 99% 1200KG/M Jinan Million Pharmaceutical Co., Ltd
3-(1-Piperazinyl)-1,2-benzisothiazole pictures 2026-06-30 3-(1-Piperazinyl)-1,2-benzisothiazole
87691-87-0
 1kg 98% 1000kg Shaanxi Dideu New Materials Co. Ltd
Lurasidone impurity 13 pictures 2026-03-12 Lurasidone impurity 13
10mg 98% 500mg ShenZhen H&D Pharmaceutical Technology Co., LTD

3-(1-Piperazinyl)-1,2-benzisothiazole Spectrum

3-(1-Piperazinyl)-1,2-benzisothiazole(87691-87-0)1HNMR

87691-87-0(3-(1-Piperazinyl)-1,2-benzisothiazole)Related Search:

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Isothiazole 1,2-Benzisothiazol-3(2H)-one 2,2'-Dithiobis(benzothiazole) Probenazole
2-Mercaptobenzothiazole 2-Methyl-4-isothiazolin-3-one Benzothiazole Ziprasidone hydrochloride monohydrate Ziprasidone QT
Ziprasidone IMpurity (6-Chloro-5-(2-Chloro-1-Hydroxy-Ethyl)-1,3-Dihydro-Indol-2-One) 3-Oxo Ziprasidone (Ziprasidone Impurity B) Ziprasidone Sulfoxide 5,5'-Bis(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6,6'-dichloro-3-hydroxy-3,3'-biindoline-2,2'-dione Ziprasidone Ring-opened IMpurity (IMpurity C)
Ziprasidone Impurity 3 Isopropylidene ziprasidone 1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE

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Ziprasidone Impurity 6（Ziprasidone EP Impurity A） lurasidone-1 3-Piperazinyl-1,2-benzisothiazole (PRB) ASINEX-REAG BAS 13031053 3-(1-PIPERAZINYL)-1,2-BENZISOTHIAZOLE 1,2-BENZISOTHIAZOLE-3-(1-PIPERAZINYL) 1-(1,2-BENZISOTHIAZOL-3-YL)PIPERAZINE 1-(1,2-BENZISOTHIAZOL-3-YL)-PIPERAZINE (BASE) 3-Piperazinyl-1,2-Benzisothiazole Hcl AKOS B030093 3-PIPERAZIN-1-YL-BENZO[D]ISOTHIAZOLE 3-PIPERAZINYL-1,2-BENZISOTHIAZOLE 3-PIPERAZINOBENZISOTHIAZOLE 2-benzisothiazole 3-Piperazinyl-1 BENZTHIAZOLE PIPERAZINE HCL 3-(Piperazin-1-yl)benzoisothiazole N-(3-Benzisothiazolyl)piperazine Lurasidone INT 2 3-piperazin-1-yl-1,2-benzothiazole Ziprasidone EP Impurity A Lurasidone Impurity 13 3-(1-Piperazinyl)-1,2-benzisothiazole> Lurasidone BIP Impurity 3-(1-PIPERAZINYL)-1 2-BENZISOTHIAZOLE BA SE 3-(1-Piperazinyl)-1,2-benzisothiazole (Lurasidone Impurity) Ziprasidone EP Impurity A/Ziprasidone RC A Ziprasidone?EP Impurity A/ Ziprasidone?Related Compound A 3-(1-Piperazinyl)benzisothiazole 3-Piperazin-1-yl-benzo[d]isothiazo ZiprasidoneEPImpurityA-d8 3-(Piperazin-1-yl)benzo[djisothiazole Antidepressant agent 10 3-(1-Piperazinyl)-1,2-benzisothiazole(Lurasidone intermediate) 4-(1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINE Lurasidone Hydrochloride Impurity 13 87691-87-0 876891-87-0 116856-87-0 C11H13N3S Sulphur Derivatives API intermediates Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Starting Raw Materials & Intermediates 87691-87-0