(S)-4-(Phenylmethyl)-2-piperazineethanol
- CAS No.
- 477220-33-0
- Chemical Name:
- (S)-4-(Phenylmethyl)-2-piperazineethanol
- Synonyms
- (S)-2-(4-Benzylpiperazin-2-yl)ethan-1-ol;(S)-2-(4-benzylpiperazin-2-yl)ethanol;2-((S)-4-benzylpiperazin-2-yl)ethanol;(s)-4-(phenylmethyl)-2-piperazineethanol;2-[(2S)-4-benzylpiperazin-2-yl]ethan-1-ol;(S)-2-(4-benzylpiperazin-2-yl)ethanol-2HCl;2-Piperazineethanol, 4-(phenylmethyl)-, (2S)-
- CBNumber:
- CB3855104
- Molecular Formula:
- C13H20N2O
- Molecular Weight:
- 220.31
- MDL Number:
- MFCD23704518
- MOL File:
- 477220-33-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H303-H320 |
| Precautionary statements | P312-P264-P305+P351+P338-P337+P313 |
(S)-4-(Phenylmethyl)-2-piperazineethanol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| aablocks | AA00DBJX | 2-[(S)-4-benzylpiperazin-2-yl]ethanol 95% | 477220-33-0 | 1g | $526 | 2026-05-28 | Buy |
| ACHEMBLOCK | K12323 | (S)-4-(Phenylmethyl)-2-piperazineethanol 95% | 477220-33-0 | 250MG | $195 | 2026-05-27 | Buy |
| ACHEMBLOCK | K12323 | (S)-4-(Phenylmethyl)-2-piperazineethanol 95% | 477220-33-0 | 1G | $585 | 2026-05-27 | Buy |
| ACHEMBLOCK | K12323 | (S)-4-(Phenylmethyl)-2-piperazineethanol 95% | 477220-33-0 | 5G | $1760 | 2026-05-27 | Buy |
| American Custom Chemicals Corporation | CCH0000498 | 2-((S)-4-BENZYLPIPERAZIN-2-YL)ETHANOL 95.00% | 477220-33-0 | 1G | $1575 | 2021-12-16 | Buy |
(S)-4-(Phenylmethyl)-2-piperazineethanol Chemical Properties, Uses, Production
Synthesis
612506-99-7
477220-33-0
General procedure for the synthesis of 2-[(S)-4-benzyl-2-yl]ethanol from the compound (CAS:612506-99-7): to a tetrahydrofuran (1L) solution of methyl S-(4-benzyl-3,6-dioxopiperazin-2-yl)acetate (31.9 g, 0.12 mol) at 0 °C, lithium aluminum hydride (350 mL, 1.0 M tetrahydrofuran solution). The reaction mixture was stirred overnight at room temperature. Subsequently, the reaction was quenched by successive careful addition of 13.3 mL of water, 13.3 mL of 15% aqueous sodium hydroxide solution and 39.9 mL of water, during which vigorous stirring was maintained to ensure the formation of a fine precipitate. The reaction mixture was filtered through a sintered funnel and the solid fraction was washed well with tetrahydrofuran and dichloromethane. The filtrate was concentrated under vacuum to give 26.5 g of an oily residue which was directly sampled on a silica gel column. Column chromatographic separation was carried out using a 5% 7N ammonia-methanol dichloromethane mixture as eluent to obtain the target product, which was an orange-colored oil and solidified to a solid after vacuum drying. This solid was dissolved in acetonitrile, sonicated for several minutes and filtered to give 7.5 g (25% yield) of S-(-)-2-(4-benzylpiperazin-2-yl)ethanol as an off-white crystalline solid with a melting point of 78.9-80 °C. The mother liquor was concentrated to give 6.8 g (23% yield) of a slightly less pure product as an amorphous solid.
References
[1] Patent: WO2003/82877, 2003, A1. Location in patent: Page/Page column 96-97
[2] Patent: WO2005/26177, 2005, A1. Location in patent: Page/Page column 91-92
[3] Patent: WO2004/14895, 2004, A1. Location in patent: Page 125-126
(S)-4-(Phenylmethyl)-2-piperazineethanol Preparation Products And Raw materials
Raw materials
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Preparation Products
(S)-4-(Phenylmethyl)-2-piperazineethanol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2712 | 61 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 4563 | 58 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 86-574-27787657 | info@dearchem.com | China | 4607 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 400-867-5858;400-867-5858 | info@amateksci.com | China | 28760 | 58 |
| Jinan Kabotang Biological Technology Co.,Ltd. | 0531-61320525 15866703830 | figo.gao@foxmail.com | China | 7601 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 17705817739 | info@dycnchem.com | China | 52451 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Nantong puyue biomedical Co., Ltd | 0513-0513-0513-89158300 18014392889 | sales@puyerbiopharma.com | China | 4956 | 58 |
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