(S)-4-(Phenylmethyl)-2-piperazineethanol
- CAS No.
- 477220-33-0
- Chemical Name:
- (S)-4-(Phenylmethyl)-2-piperazineethanol
- Synonyms
- (S)-2-(4-benzylpiperazin-2-yl)ethanol;2-((S)-4-benzylpiperazin-2-yl)ethanol;(s)-4-(phenylmethyl)-2-piperazineethanol;(S)-2-(4-Benzylpiperazin-2-yl)ethan-1-ol;2-[(2S)-4-benzylpiperazin-2-yl]ethan-1-ol;(S)-2-(4-benzylpiperazin-2-yl)ethanol-2HCl;2-Piperazineethanol, 4-(phenylmethyl)-, (2S)-
- CBNumber:
- CB3855104
- Molecular Formula:
- C13H20N2O
- Molecular Weight:
- 220.31
- MDL Number:
- MFCD23704518
- MOL File:
- 477220-33-0.mol
(S)-4-(Phenylmethyl)-2-piperazineethanol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| American Custom Chemicals Corporation | CCH0000498 | 2-((S)-4-BENZYLPIPERAZIN-2-YL)ETHANOL 95.00% | 477220-33-0 | 1G | $1575 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | CCH0000498 | 2-((S)-4-BENZYLPIPERAZIN-2-YL)ETHANOL 95.00% | 477220-33-0 | 5G | $2708.48 | 2021-12-16 | Buy |
(S)-4-(Phenylmethyl)-2-piperazineethanol Chemical Properties,Uses,Production
Synthesis
612506-99-7
477220-33-0
General procedure for the synthesis of 2-[(S)-4-benzyl-2-yl]ethanol from the compound (CAS:612506-99-7): to a tetrahydrofuran (1L) solution of methyl S-(4-benzyl-3,6-dioxopiperazin-2-yl)acetate (31.9 g, 0.12 mol) at 0 °C, lithium aluminum hydride (350 mL, 1.0 M tetrahydrofuran solution). The reaction mixture was stirred overnight at room temperature. Subsequently, the reaction was quenched by successive careful addition of 13.3 mL of water, 13.3 mL of 15% aqueous sodium hydroxide solution and 39.9 mL of water, during which vigorous stirring was maintained to ensure the formation of a fine precipitate. The reaction mixture was filtered through a sintered funnel and the solid fraction was washed well with tetrahydrofuran and dichloromethane. The filtrate was concentrated under vacuum to give 26.5 g of an oily residue which was directly sampled on a silica gel column. Column chromatographic separation was carried out using a 5% 7N ammonia-methanol dichloromethane mixture as eluent to obtain the target product, which was an orange-colored oil and solidified to a solid after vacuum drying. This solid was dissolved in acetonitrile, sonicated for several minutes and filtered to give 7.5 g (25% yield) of S-(-)-2-(4-benzylpiperazin-2-yl)ethanol as an off-white crystalline solid with a melting point of 78.9-80 °C. The mother liquor was concentrated to give 6.8 g (23% yield) of a slightly less pure product as an amorphous solid.
References
[1] Patent: WO2003/82877, 2003, A1. Location in patent: Page/Page column 96-97
[2] Patent: WO2005/26177, 2005, A1. Location in patent: Page/Page column 91-92
[3] Patent: WO2004/14895, 2004, A1. Location in patent: Page 125-126
(S)-4-(Phenylmethyl)-2-piperazineethanol Preparation Products And Raw materials
Raw materials
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Preparation Products
(S)-4-(Phenylmethyl)-2-piperazineethanol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52846 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178; | peter68@ptchemgroup.com | China | 35425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49977 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| ForeChem (Nantong) Technology Co.,Ltd. | 513-85982855 18921614129 | sales@xianxingpharm.com | China | 2986 | 61 |
| SynAsst Chemical. | 021-60343070 | China | 12740 | 55 | |
| Nantong MYBio-pharm. Co., Ltd. | 0513-85921823 18662920231 | sales@ntminyanmedical.com | China | 3994 | 58 |
| NINGBO INNO PHARMCHEM CO.,LTD. | 86-574-27787657 | info@dearchem.com | China | 4613 | 58 |
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