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1-Actamido-3,5-dimethyladmantane

1-Actamido-3,5-dimethyladmantane structure

CAS No.: 19982-07-1

Chemical Name:: 1-Actamido-3,5-dimethyladmantane

Synonyms: Acetyl memantine;Memantine N-Acetyl;N-Acetyl Memantine ;MeMantine IMpurity C;Memantine impurity E;Memantine Acetyl Impurity;Memantine Related Compound F;Memantine Impurity C (N-Acetyl;1-actamido-3,5-dimethyladmantane;1-ACETAMIDO-3,5-DIMETHYLADMANTANE

CBNumber:: CB3855230

Molecular Formula:: C14H23NO

Molecular Weight:: 221.34

MDL Number:: MFCD06656139

MOL File:: 19982-07-1.mol

MSDS File:: SDS

Last updated:2025-08-21 22:16:43

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1-Actamido-3,5-dimethyladmantane Properties

Melting point	110-111°C
Boiling point	348.5±9.0 °C(Predicted)
Density	1.05
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform (Sparingly), Ethyl Acetate (Slightly)
pka	16.20±0.60(Predicted)
form	Solid
color	White
CAS DataBase Reference	19982-07-1(CAS DataBase Reference)
UNSPSC Code	41116107
NACRES	NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS03,GHS07
Signal word	Warning
Hazard statements	H227
Precautionary statements	P501-P210-P280-P370+P378-P403+P235
HS Code	2902190000

1-Actamido-3,5-dimethyladmantane price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemical	A2653	N-Acetyl-3,5-dimethyl-1-adamantanamine >97.0%(GC)	19982-07-1	1g	$208	2025-07-31	Buy
TCI Chemical	A2653	N-Acetyl-3,5-dimethyl-1-adamantanamine >97.0%(GC)	19982-07-1	5g	$734	2025-07-31	Buy
American Custom Chemicals Corporation	CHM0006455	1-ACTAMIDO-3,5-DIMETHYLADMANTANE 95.00%	19982-07-1	1G	$1770.62	2021-12-16	Buy
Medical Isotopes, Inc.	19232	N-AcetylMemantine	19982-07-1	1g	$1960	2021-12-16	Buy
Biosynth Carbosynth	IA11847	N-Acetylmemantine	19982-07-1	5G	$200	2021-12-16	Buy

Product number	Packaging	Price	Buy
A2653	1g	$208	Buy
A2653	5g	$734	Buy
CHM0006455	1G	$1770.62	Buy
19232	1g	$1960	Buy
IA11847	5G	$200	Buy

1-Actamido-3,5-dimethyladmantane Chemical Properties,Uses,Production

Chemical Properties

1-Actamido-3,5-dimethyladmantane is White Solid

Uses

1-Actamido-3,5-dimethyladmantane is an intermediate used for preparation of Memantine (M218000).

Synthesis

707-37-9

75-05-8

19982-07-1

[0063] 1.00 g (5.50 mmol) of 3,5-dimethyl-1-adamantanol, 0.46 g (11.1 mmol) of acetonitrile, and 9.61 g of homotrimethylbenzene were added to a test tube with an outer diameter of 30 mm and mixed well. Subsequently, 1.12 g (11.1 mmol) of 97% concentrated sulfuric acid was slowly added dropwise to the mixed solution in the test tube to form a reaction solution. The reaction solution was stirred at a constant temperature at 30°C for 3 hours to promote the reaction. Upon completion of the reaction, 6.09 g of water was added to the reaction solution to quench the reaction, and the aqueous phase was removed by aqueous washing to obtain a homotrimethylbenzene solution containing 1-acetamido-3,5-dimethyladamantane (reaction yield: 80.4%). Next, 0.71 g of sodium hydroxide hydrate and 9.61 g of 1-hexanol were added to this solution to prepare a reaction solution. The reaction solution was stirred at 130 °C for 18 h to achieve hydrolysis of 1-acetamido-3,5-dimethyladamantane. Finally, the reaction solution was analyzed by gas chromatography (GC) to confirm the generation of memantine (reaction yield: 96.2%).

References

[1] Journal of Organic Chemistry USSR (English Translation), 1982, vol. 18, p. 867 - 871
[2] Zhurnal Organicheskoi Khimii, 1982, vol. 18, # 5, p. 1001 - 1005
[3] Patent: EP2949643, 2015, A1. Location in patent: Paragraph 0063

1-Actamido-3,5-dimethyladmantane Preparation Products And Raw materials

Raw materials

1,3-Dimethyladamantane Acetamide 1-Chloro-3,5-dimethyladamantane 3,5-Dimethyl-1-adamantanol 1-Bromo-3,5-dimethyladamantane

Acetonitrile Sulfuric acid Mesitylene

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Preparation Products

Acetamide, N-(3-hydroxy-5,7-dimethyltricyclo[3.3.1.13,7]dec-1-yl)- 3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride

1-Actamido-3,5-dimethyladmantane Suppliers

Global( 235)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan JiyunZen Tech Co., Ltd.	+86-18062099985	Amyjiyunzen@yeah.net	China	663	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29733	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	FandaChem@Gmail.com	China	1631	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49730	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12332	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
Wuhan JiyunZen Tech Co., Ltd.	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Standardpharm Co. Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
Zhengzhou Alfa Chemical Co.,Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from 1-Actamido-3,5-dimethyladmantane manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2025-08-28	1-Actamido-3,5-dimethyladmantane 19982-07-1	US $5.00-0.50 / KG	1KG	99% hplc	500TONS	Wuhan JiyunZen Tech Co., Ltd.
2025-08-21	N-(3,5-Dimethyladamantan-1-yl)acetamide 19982-07-1	US $48.00-68.00 / mg			10g	TargetMol Chemicals Inc.
2025-04-04	1-Actamido-3,5-dimethyladmantane 19982-07-1	US $0.00-0.00 / KG	1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

1-Actamido-3,5-dimethyladmantane
19982-07-1
US $5.00-0.50 / KG
99% hplc
Wuhan JiyunZen Tech Co., Ltd.

N-(3,5-Dimethyladamantan-1-yl)acetamide
19982-07-1
US $48.00-68.00 / mg
TargetMol Chemicals Inc.

1-Actamido-3,5-dimethyladmantane
19982-07-1
US $0.00-0.00 / KG
98%
Henan Aochuang Chemical Co.,Ltd.

1-Actamido-3,5-dimethyladmantane Spectrum

1-Actamido-3,5-dimethyladmantane(19982-07-1)¹HNMR

19982-07-1(1-Actamido-3,5-dimethyladmantane)Related Search:

ETHANE Dacthal Dimethyl fumarate Dimethyl carbonate Dimethyl sulfate

Dimethyl sulfoxide Acetamide Acetaminophen N,N-Dimethylformamide Dimethyl ether

Dimethyl phthalate 1-Hydroxy-3-amino-5,7-dimethyladamantane hydrochloride Tricyclo[3.3.1.13,7]decan-1-aMine, 3,5,7-triMethyl-, hydrochloride 3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride Memantine Lactose Adduct

Memantine Related Compound 1 Adamantane 1-Actamido-3,5-dimethyladmantane

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n-(3,5-dimethyl-1-adamantyl)-acetamide 1-ACETAMIDO-3,5-DIMETHYLADMANTANE 1-Acetamido-3,5-dimethyladamantane 1-acetate amino-3，5- Dimethyl Adamantane 1. 1-actamido-3,5-dimethyladmantane N-Acetyl Memantine AcetylaMino-3,5-diMethyladaMantane Acetamide,N-(3,5-dimethyltricyclo[3.3.1.13,7]dec-1-yl)- N-Acetyl-3,5-diMethyl-1-adaMantanaMine 1-actamido-3,5-dimethyladmantane N-(3,5-DiMethyltricyclo[3.3.1.13,7]dec-1-yl)acetaMide 1-N-AcetylaMino-3,5-diMethyladaMantane N-(3,5-diMethyladaMantan-1-yl)acetaMide MeMantine IMpurity C N-Acetyl-3,5-dimethyl-1-adamantanamine Memantine impurity E N-((1r,3R,5S,7r)-3,5-dimethyladamantan-1-yl)acetamide 1-Actamido-3,5-dimethyladamantane Memantine Acetyl Impurity Acetyl memantine Memantine Impurity 14(N-Acetyl Memantine) Memantine Impurity C (N-Acetyl Memantine) N-Acetyl-3,5-dimethyl-1-adamantanamine > Memantine Related Compound F Memantine N-Acetyl Memantine Impurity C (N-Acetyl Memantine Impurity 1 (N-Acetyl Memantine) N-Acetyl-3,5-dimethyl-1-adamantanamine, ≥ 97.0% Memantine Hydrochloride Impurity C 1-Acylamino-3,5-dimethyladamantane 19982-07-1 Amines Intermediates Intermediates & Fine Chemicals Pharmaceuticals