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1-Bromo-3,5-dimethyladamantane

1-Bromo-3,5-dimethyladamantane Structure
1-Bromo-3,5-dimethyladamantane structure
CAS No.
941-37-7
Chemical Name:
1-Bromo-3,5-dimethyladamantane
Synonyms
MeMantine IMpurity B;Memantine impurity D;1-Bromo-3,5-Dimethyl;MeMantine Related CoMpound D;(1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane;NSC 102293;Memantine USP RC D;Adamantane Impurity D;1-Bromo-3,5-dimethyladama;Hydrochloride intermediate
CBNumber:
CB6263645
Molecular Formula:
C12H19Br
Molecular Weight:
243.18
MDL Number:
MFCD00077197
MOL File:
941-37-7.mol
MSDS File:
SDS
Last updated:2026-05-28 04:59:53
Product description Number Pack Size Price
1-BROMO-3,5-DIMETHYLADAMANTANE AldrichCPR S694541 1 unit $197
1-Bromo-3,5-dimethyladamantane 98% 187844 5g $73.1
Memantine Related Compound D Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 100?mg PHR2583 100MG $424
Memantine Related Compound D United States Pharmacopeia (USP) Reference Standard 1380546 50mg $1390
1-Bromo-3,5-dimethyladamantane >98.0%(GC) B1821 5g $35
More product size
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1-Bromo-3,5-dimethyladamantane Properties

Boiling point 201 °C (lit.)
Density 1.224 g/mL at 25 °C (lit.)
refractive index n20/D 1.52(lit.)
Flash point 228 °F
storage temp. 2-8°C
solubility Chloroform (Sparingly), Dichloromethane (Slightly), Methanol (Slightly)
form Oil
color Colourless to Pale Yellow
Specific Gravity 1.224
BRN 1927514
Major Application pharmaceutical small molecule
InChI InChI=1S/C12H19Br/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10/h9H,3-8H2,1-2H3
InChIKey QUCXLVDIVQWYJR-UHFFFAOYSA-N
SMILES C12(Br)CC3(C)CC(CC(C)(C3)C1)C2
CAS DataBase Reference 941-37-7(CAS DataBase Reference)
FDA UNII SE68KQ68T1
UNSPSC Code 41116107
NACRES NA.24

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338
Hazard Codes  C
Risk Statements  34-36
Safety Statements  26-27-36/37/39-45
WGK Germany  3
HazardClass  IRRITANT
HS Code  2903890002
Storage Class 10 - Combustible liquids
REACH Registrations Active
NFPA 704
1
0 0

1-Bromo-3,5-dimethyladamantane price More Price(43)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich S694541 1-BROMO-3,5-DIMETHYLADAMANTANE AldrichCPR 941-37-7 1 unit $197 2026-04-30 Buy
Sigma-Aldrich 187844 1-Bromo-3,5-dimethyladamantane 98% 941-37-7 5g $73.1 2026-04-30 Buy
Sigma-Aldrich PHR2583 Memantine Related Compound D Pharmaceutical Secondary Standard; Certified Reference Material, certified reference material, pharmaceutical secondary standard, pkg of 100?mg 941-37-7 100MG $424 2026-04-30 Buy
Sigma-Aldrich 1380546 Memantine Related Compound D United States Pharmacopeia (USP) Reference Standard 941-37-7 50mg $1390 2026-04-30 Buy
TCI Chemical B1821 1-Bromo-3,5-dimethyladamantane >98.0%(GC) 941-37-7 5g $35 2026-04-30 Buy
Product number Packaging Price Buy
S694541 1 unit $197 Buy
187844 5g $73.1 Buy
PHR2583 100MG $424 Buy
1380546 50mg $1390 Buy
B1821 5g $35 Buy

1-Bromo-3,5-dimethyladamantane Chemical Properties,Uses,Production

Uses

1-Bromo-3,5-dimethyladamantane (cas# 941-37-7) is a compound useful in organic synthesis.

Description

1-Bromo-3,5-dimethyladamantane is a precursor substance of memantine and memantine hydrochloride (MH), which can be synthesised by direct amination with thiourea. MH is an FDA-approved first-line treatment for moderate to severe Alzheimer's disease.

Chemical Properties

Clear Colorless Oil

Uses

1-Bromo-3,5-dimethyladamantane was used in the one pot synthesis of 1,3-dicarbonyl adamantanes. It was also used in the synthesis of 3,5-dimethyladamantan-1-ol.

Synthesis

1,3-Dimethyladamantane

702-79-4

1-Bromo-3,5-dimethyladamantane

941-37-7

A) Add 59.9 g (0.345 mol) of bromine, 10 g (0.075 mol) of anhydrous aluminum trichloride, and 37.8 g of 1,2-dichloroethane to the reactor with thorough stirring; B) Heat the reaction mixture A to 15°C; C) Add 50 g (0.3 mol) of 1,3-dimethyladamantane to the mixture obtained in step B, and absorb the resulting gas using a 5% sodium hydroxide solution; D) Add 400 g of saturated sodium bisulfite solution to reaction mixture B until the red color of the reaction solution completely disappears, and separate the organic phase C and the aqueous phase D; and D) Add 400 g of saturated sodium bisulfite solution to the reaction mixture B until the red color of the reaction solution completely disappears, and separate the organic phase C and the aqueous phase D; E) Wash the organic phase C with 400 g of water, and then dry it with 20 g of anhydrous sodium sulfate; F) Perform distillation on the organic phase C obtained in step E to obtain the crude product E; G) Perform decompression distillation on the crude product E to obtain the 1-(3-methyladamantyl)-1,3-dimethyladamantane. G) the crude product E was distilled under reduced pressure to obtain 1-bromo-3,5-dimethyladamantane in 92% yield and ≥99% purity by gas chromatography.

References

[1] Patent: CN104592034, 2016, B. Location in patent: Paragraph 0092-0099
[2] Asian Journal of Chemistry, 2012, vol. 24, # 11, p. 5107 - 5110
[3] Russian Journal of Organic Chemistry, 2015, vol. 51, # 2, p. 184 - 187
[4] Zh. Org. Khim., 2015, vol. 51, # 2, p. 196 - 199
[5] Patent: US5061703, 1991, A

1-Bromo-3,5-dimethyladamantane synthesis

702-79-4
941-37-7
Synthesis of 1-Bromo-3,5-dimethyladamantane from 1,3-Dimethyladamantane

1-Bromo-3,5-dimethyladamantane Preparation Products And Raw materials

Raw materials

1,3-Dimethyladamantane Aluminum chloride 1,2-Dichloroethane

Preparation Products

1,3-Dimethyladamantane 3-AMINO-5,7-DIMETHYLADAMANTAN-1-OL Hydrochloride 1,3,5-TRIMETHYLADAMANTANE 4-(3,5-dimethyl-1-adamantyl)phenol

1-Bromo-3,5-dimethyladamantane Suppliers

Global( 491)Suppliers
Supplier Tel Email Country ProdList Advantage
Jinan Qinmu Fine Chemical Co.,Ltd.
+8618660799346 sales@qinmuchem.com China 1008 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30224 58
Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd.
+86-025-86819862 +86-13913839793 sales@jinchemical.com China 29 58
Anhui Zhongda Biotechnology Co., Ltd
+8615689548120 linda@zhongda-biotech.com China 193 58
Beijing Toachem Chemical Co.,Ltd
+8618311365218 sales@toachem.com China 205 58
Jinan Hong Kongda Chemical Co.,LTD
+86-18753193522 +86-18753193522 sales@hkdchem.com China 97 58
Hebei Chuanghai Biotechnology Co., Ltd 		+8615350571055 Sibel@chuanghaibio.com China 8738 58
Hebei Yanxi Chemical Co., Ltd. 		+8618531123677 faithe@yan-xi.com China 5853 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-86-13131129325 +8613131129325 sales1@chuanghaibio.com China 5225 58
Shandong Huisheng Import & Export Co., Ltd. 		+86-13176845580 da@zhongda-biotech.com China 232 58
Supplier Advantage
Jinan Qinmu Fine Chemical Co.,Ltd.
58
Career Henan Chemica Co
58
Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd.
58
Anhui Zhongda Biotechnology Co., Ltd
58
Beijing Toachem Chemical Co.,Ltd
58
Jinan Hong Kongda Chemical Co.,LTD
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Shandong Huisheng Import & Export Co., Ltd. 		58

Related articles

View Lastest Price from 1-Bromo-3,5-dimethyladamantane manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
1-Bromo-3,5-dimethyladamantane pictures 2026-06-15 1-Bromo-3,5-dimethyladamantane
941-37-7
 1KG 99% 200mt/year Jinan Finer Chemical Co., Ltd
1-Bromo-3,5-dimethyladamantane pictures 2026-06-12 1-Bromo-3,5-dimethyladamantane
941-37-7
 1kg 99% 1 Nanjing Shunxiang Pharmaceutical Technology Co.,Ltd.
1-Bromo-3, 5-Dimethyladamantane pictures 2026-05-28 1-Bromo-3, 5-Dimethyladamantane
941-37-7
 $10.00 1KG 99% 10 ton Hebei Chuanghai Biotechnology Co,.LTD

1-Bromo-3,5-dimethyladamantane Spectrum

1-Bromo-3,5-dimethyladamantane(941-37-7)MS1-Bromo-3,5-dimethyladamantane(941-37-7)1HNMR1-Bromo-3,5-dimethyladamantane(941-37-7)13CNMR1-Bromo-3,5-dimethyladamantane(941-37-7)IR11-Bromo-3,5-dimethyladamantane(941-37-7)Raman

941-37-7(1-Bromo-3,5-dimethyladamantane)Related Search:

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1-Bromo-3,5-dimethyltricyclo[3.3.1.13,7]decane 1-BROMO-3,5-DIMETHYLADAMANTANE 3,5-dimethyl-1-bromo- adamantane 1-Bromo-3,5-Dimethyl 1,3-Dimethyl-5-bromoadamantane tricyclo[3.3.1.1~3,7~]decane, 1-bromo-3,5-dimethyl- NSC 102293 1-BROMO-3,5- DIMETHYL DAMANTANE MeMantine Related CoMpound D 1- broMo-3,5- tworiMantadine Memantine Related Compound D (50 mg) (1-Bromo-3,5-dimethyladamantane) Memantine USP RC D 1-Bromo-3,5-dimethyladamantane 98% 1-Bromo-3,5-dimethyladama Memantine Impurity 4(Memantine USP RC D) Memantine USP Related Compound D Hydrochloride intermediate (1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane 1-Bromo-3,5-dimethyladamantane > 1-Bromo-3,5-dimethyladamantane ISO 9001：2015 REACH Memantine Related Compund D (1-Bromo-3,5-dimethyladamantane) Adamantane Impurity D Memantine Related Compound D (1-Bromo-3,5-dimethyladamantane) (1380546) 1-bromo-3, 5-dimethylfungane Memantine Related Compound D (1r,3R,5S,7r)-1-bromo-3,5-dimethyladamantane USP hydrochloride memantine impurity D MeMantine IMpurity B Memantine impurity D Memantine Hydrochloride Impurity 4 (Memantine USP Related Compound D) 941-37-7 941-27-7 941-37-3 C12H19Br Building Blocks Alkyl Adamantanes Halogenated Hydrocarbons Organic Building Blocks Adamantane derivatives Adamantanes Alkyl Halogenated Hydrocarbons Organic Building Blocks Intermediates & Fine Chemicals Pharmaceuticals Chemical intermediate for Memantine HCl bc0001 941-37-7