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1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester

1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester structure

CAS No.: 37813-30-2

Chemical Name:: 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester

Synonyms: 37813-30-2);Boc-L-Hyp-oet;BOC-L-Proline Ethyl ester;Boc-L-Hydroxy-Proline Ethyl Ester;1-Boc-L-hydroxyproline ethyl ester;1-Boc-4-Hydroxy-L-Proline Ethyl Ester;(Tert-Butoxy)Carbonyl Hyp-OEt (Syrup);(4R)-1-Boc-4-hydroxy-L-proline ethyl ester;(2S,4R)-N-Boc-trans-4-hydroxy-L-proline ethyl ester;1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester

CBNumber:: CB3947104

Molecular Formula:: C12H21NO5

Molecular Weight:: 259.3

MDL Number:: MFCD09264314

MOL File:: 37813-30-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 02:48:15

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1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Properties

Boiling point	350.2±42.0 °C(Predicted)
Density	1.189±0.06 g/cm3(Predicted)
storage temp.	2-8°C
pka	14.30±0.40(Predicted)
form	Viscous Liquid
color	Colorless to light yellow
optical activity	Consistent with structure

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P301+P312-P302+P352-P304+P340-P305+P351+P338

1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
ChemScene	CS-0045010	Boc-Hyp-OEt ≥97%	37813-30-2	1g	$7	2026-06-04	Buy
ChemScene	CS-0045010	Boc-Hyp-OEt ≥97%	37813-30-2	5g	$9	2026-06-04	Buy
ChemScene	CS-0045010	Boc-Hyp-OEt ≥97%	37813-30-2	10g	$15	2026-06-04	Buy
ChemScene	CS-0045010	Boc-Hyp-OEt ≥97%	37813-30-2	25g	$26	2026-06-04	Buy
ChemScene	CS-0045010	Boc-Hyp-OEt ≥97%	37813-30-2	100g	$89	2026-06-04	Buy

Product number	Packaging	Price	Buy
CS-0045010	1g	$7	Buy
CS-0045010	5g	$9	Buy
CS-0045010	10g	$15	Buy
CS-0045010	25g	$26	Buy
CS-0045010	100g	$89	Buy

1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Chemical Properties, Uses, Production

Uses

Boc-Hyp-OEt is a proline derivative[1].

Synthesis

24424-99-5

33996-30-4

1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester

37813-30-2

Step 2: Ethyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride (146.2 g, 0.747 mol) was dissolved in a solvent mixture of dichloromethane (1,600 mL) and ethanol (100 mL) and cooled to 0°C. Triethylamine (113.4 g, 1.12 mol, 156.2 mL) was added to this solution with stirring. Subsequently, di-tert-butyl dicarbonate (195.6 g, 0.90 mol) was added in batches. The reaction mixture was stirred at 0 °C for 15 minutes, then brought to room temperature and continued stirring for 16 hours. Upon completion of the reaction, the mixture was concentrated to about 800 mL and washed with water. The organic layer was dried with magnesium sulfate, filtered and concentrated. Purification by silica gel column chromatography (eluent: 20% ethyl acetate-dichloromethane) afforded ethyl Boc-L-hydroxyproline (193.7 g, 100%) as a yellow oil. Mass spectrum (M + Na): m/e 282. 1H-NMR (CDCl3) δ 1.30 (t, 3H), 1.45 (s, 9H), 1.75 (m, 1H), 2.10 (m, 1H), 2.30 (m, 1H), 3.45 and 3.55 (d, 1H, two rotary isomers), 3.65 (dd, 1H), 4.25 (m, 2H ), 4.40 and 4.45 (t, 1H, two rotary isomers), 4.55 (broad s, 1H).

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate Boc-Hyp-OH Iodoethane H-Hyp-OEt HCl L-Proline, 4-hydroxy-, ethyl ester, (4R)- (9CI)

Ethanol Triethylamine Dichloromethane

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Preparation Products

(2S,4R)-1-Boc-4-amino-pyrrolidine-2-carboxylic acid

1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Suppliers

Global Suppliers ( 97)

Supplier	Tel	Email	Country	ProdList	Advantage
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
AstaTech (Chengdu) Pharma. Co., Ltd.	15928766785 15928766785	wupengcheng@astatech.cn	China	1998	55
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632;	sales@reading-chemicals.com	China	15165	58
Shanghai CanSpecsci Instrument Co., Ltd.	400-6087598 15021221957	order@canspecsci.com	China	2001	56
Shanghai YuLue Chemical Co., Ltd.	021-60345187 13671753212	lzz841106@aliyun.com	China	10244	55
Nanjing Derno Pharmaceutical Technology Co., Ltd.	02585057128;025-86957866 13952093866	sales@dernopharm.com	China	943	58
Chengdu Chuangkecheng Biological Technology Co., Ltd.	028-028-0000000 13008177686	sales@ckcbiotech.com	China	899	55

Supplier	Advantage
J & K SCIENTIFIC LTD.	76
Energy Chemical	61
Shanghai Hanhong Scientific Co.,Ltd.	64
AstaTech (Chengdu) Pharma. Co., Ltd.	55
Bide Pharmatech Ltd.	60
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Shanghai CanSpecsci Instrument Co., Ltd.	56
Shanghai YuLue Chemical Co., Ltd.	55
Nanjing Derno Pharmaceutical Technology Co., Ltd.	58
Chengdu Chuangkecheng Biological Technology Co., Ltd.	55

View Latest Price from 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-25	Boc-Hyp-Oet 37813-30-2	$2.00-6.00	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
	2020-02-05	1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester 37813-30-2	$3.00	1KG	98%	100KG	Career Henan Chemical Co

Boc-Hyp-Oet
37813-30-2
$2.00-6.00
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester
37813-30-2
$3.00
98%
Career Henan Chemical Co

1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Spectrum

1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester(37813-30-2)¹HNMR

37813-30-2 (1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester ) Related Search:

Boc-L-beta-Homoproline N-Boc-D-alaninol Boc-O-benzyl-L-tyrosine Boc-L-transpro(OTs)-OBn Boc-Hyp-OtBu

Boc-Hyp-OBzl N-Boc-cis-4-Hydroxy-L-proline methyl ester Boc-Hyp-OH N-Boc-trans-4-Hydroxy-L-proline methyl ester 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester

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1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester 1-Boc-4-Hydroxy-L-Proline Ethyl Ester 1-tert-butyl 2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate (2S)-4-hydroxypyrrolidine-1,2-dicarboxylic acid O1-tert-butyl ester O2-ethyl ester (2S,4R)-1-BOC-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID ETHYL ESTER Boc-L-Hydroxy-Proline Ethyl Ester (2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester 1-Boc-L-hydroxyproline ethyl ester (2S-trans)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-(1,1-dimethylethyl) 2-ethyl ester 1-tert-Butoxycarbonyl-4R-hydroxy-L-proline ethyl ester (2S,4R)-1-tert-Butyl 2-ethyl 4-hydroxypyrrolidine-1,2-dicarboxylate 37813-30-2) (2S)-1-tert-butyl 2-ethyl 4-hydroxypyrrolidine-1,2-dicarboxylate (4R)-1-Boc-4-hydroxy-L-proline ethyl ester Boc-L-Hyp-oet (Tert-Butoxy)Carbonyl Hyp-OEt (Syrup) (2S,4R)-1-BOC-4-HYDROXYPYRROLININE-2-CARBOXYLIC ACID ETHYL ESTER 1,2-Pyrrolidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-ethyl ester, (2S,4R)- 1-(tert-butyl) 2-ethyl (2S)-4-hydroxypyrrolidine-1,2-dicarboxylate 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester USP/EP/BP O1-tert-butyl O2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate Ethyl (2S,4R)-1-Boc-4-Hydroxypyrrolidine-2-carboxylate (2S,4R)-N-Boc-trans-4-hydroxy-L-proline ethyl ester BOC-L-Proline Ethyl ester 37813-30-2