| Company Name: |
Energy Chemical |
| Tel: |
400-0056266 |
| Email: |
sales8178@energy-chemical.com |
- Boc-Hyp-Oet
-
- $2.00
-
2026-08-25
- CAS:37813-30-2
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100kg
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| | 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Basic information |
| Product Name: | 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester | | Synonyms: | 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester;1-Boc-4-Hydroxy-L-Proline Ethyl Ester;1-tert-butyl 2-ethyl (2S,4R)-4-hydroxypyrrolidine-1,2-dicarboxylate;(2S)-4-hydroxypyrrolidine-1,2-dicarboxylic acid O1-tert-butyl ester O2-ethyl ester;(2S,4R)-1-BOC-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID ETHYL ESTER;Boc-L-Hydroxy-Proline Ethyl Ester;(2S,4R)-4-Hydroxy-1,2-pyrrolidinedicarboxylic acid 1-tert-butyl 2-ethyl ester;1-Boc-L-hydroxyproline ethyl ester | | CAS: | 37813-30-2 | | MF: | C12H21NO5 | | MW: | 259.3 | | EINECS: | | | Product Categories: | | | Mol File: | 37813-30-2.mol |  |
| | 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Chemical Properties |
| Boiling point | 350.2±42.0 °C(Predicted) | | density | 1.189±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 14.30±0.40(Predicted) | | form | Viscous Liquid | | color | Colorless to light yellow | | Optical Rotation | Consistent with structure |
| | 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Usage And Synthesis |
| Uses | Boc-Hyp-OEt is a proline derivative[1]. | | Synthesis | Step 2: Ethyl (2S,4R)-4-hydroxypyrrolidine-2-carboxylate hydrochloride (146.2 g, 0.747 mol) was dissolved in a solvent mixture of dichloromethane (1,600 mL) and ethanol (100 mL) and cooled to 0°C. Triethylamine (113.4 g, 1.12 mol, 156.2 mL) was added to this solution with stirring. Subsequently, di-tert-butyl dicarbonate (195.6 g, 0.90 mol) was added in batches. The reaction mixture was stirred at 0 °C for 15 minutes, then brought to room temperature and continued stirring for 16 hours. Upon completion of the reaction, the mixture was concentrated to about 800 mL and washed with water. The organic layer was dried with magnesium sulfate, filtered and concentrated. Purification by silica gel column chromatography (eluent: 20% ethyl acetate-dichloromethane) afforded ethyl Boc-L-hydroxyproline (193.7 g, 100%) as a yellow oil. Mass spectrum (M + Na): m/e 282. 1H-NMR (CDCl3) δ 1.30 (t, 3H), 1.45 (s, 9H), 1.75 (m, 1H), 2.10 (m, 1H), 2.30 (m, 1H), 3.45 and 3.55 (d, 1H, two rotary isomers), 3.65 (dd, 1H), 4.25 (m, 2H ), 4.40 and 4.45 (t, 1H, two rotary isomers), 4.55 (broad s, 1H). | | References | [1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368 |
| | 1-tert-butoxycarbonyl-4-hydroxy-L-proline ethyl ester Preparation Products And Raw materials |
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