2-Iodo-5-trifluoromethylpyridine
- CAS No.
- 100366-75-4
- Chemical Name:
- 2-Iodo-5-trifluoromethylpyridine
- Synonyms
- 2-Iodo-5-(Trifluoromethyl)Pyri;2-Iodo-5-trifluoromethylpyridine;5-(trifluoromethyl)-2-iodopyridine;2-Iodo-5-(trifluoromethyl)pyridine;Pyridine,2-iodo-5-(trifluoroMethyl)-;2-Iodo-5-(trifluoromethyl)pyridine 98%;6-Iodo-alpha,alpha,alpha-trifluoro-3-picoline;2-Iodo-5-trifluoromethylpyridine ISO 9001：2015 REACH
- CBNumber:
- CB3967362
- Molecular Formula:
- C6H3F3IN
- Molecular Weight:
- 272.99
- MDL Number:
- MFCD08741351
- MOL File:
- 100366-75-4.mol
- MSDS File:
- SDS
| Melting point | 82-83 °C(Solv: hexane (110-54-3)) |
|---|---|
| Boiling point | 215.7±40.0 °C(Predicted) |
| Density | 1.974±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| form | solid |
| pka | -0.58±0.10(Predicted) |
| color | Off-white |
| Sensitive | Light Sensitive |
| InChI | 1S/C6H3F3IN/c7-6(8,9)4-1-2-5(10)11-3-4/h1-3H |
| InChIKey | WSEVWIIOEQZEOU-UHFFFAOYSA-N |
| SMILES | FC(F)(F)c1ccc(I)nc1 |
| UNSPSC Code | 12352200 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| Hazard Codes | Xi,T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| PackingGroup | Ⅲ | |||||||||
| HS Code | 2933399990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| NFPA 704 |
|
2-Iodo-5-trifluoromethylpyridine price More Price(60)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | ADE000407 | 2-Iodo-5-trifluoromethyl-pyridine Aldrich | 100366-75-4 | 1g | $529 | 2026-04-30 | Buy |
| Apolloscientific | PC9199 | 2-Iodo-5-(trifluoromethyl)pyridine 98% | 100366-75-4 | 250mg | $25 | 2026-06-04 | Buy |
| Apolloscientific | PC9199 | 2-Iodo-5-(trifluoromethyl)pyridine 98% | 100366-75-4 | 1g | $29 | 2026-06-04 | Buy |
| Apolloscientific | PC9199 | 2-Iodo-5-(trifluoromethyl)pyridine 98% | 100366-75-4 | 5g | $30 | 2026-06-04 | Buy |
| Apolloscientific | PC9199 | 2-Iodo-5-(trifluoromethyl)pyridine 98% | 100366-75-4 | 25g | $98 | 2026-06-04 | Buy |
2-Iodo-5-trifluoromethylpyridine Chemical Properties, Uses, Production
Application
5-Trifluoromethyl-2-iodopyridine is a pyridine compound. Due to the electron-deficient nature of the pyridine ring, the iodine atom in its structure can undergo deiodination under the attack of strong nucleophiles. It can also undergo cross-coupling reactions with aryl halides catalyzed by metallic copper. Furthermore, this substance can undergo deiodination cyanation with aryl iodine in the presence of copper cyano, and can be used in the synthesis of pyridine cyanides.
Synthesis
52334-81-3
75-36-5
100366-75-4
a) Synthesis of 2-iodo-5-trifluoromethylpyridine: Sodium iodide (43.3 g, 289.1 mmol) was added to a solution of 2-chloro-5-trifluoromethylpyridine (15.0 g, 82.6 mmol) in acetonitrile (400 mL), and the reaction mixture was stirred at 88 °C until the sodium iodide was completely dissolved. Subsequently, acetyl chloride (8.8 mL, 12.3 mmol) was slowly added dropwise to the solution and precipitation was observed. The reaction mixture was refluxed for 24 hours, cooled and concentrated to give an oil. The oil was dissolved in dichloromethane, washed sequentially with 10% sodium thiosulfate solution, 10% sodium carbonate solution and saturated saline, dried over anhydrous magnesium sulfate, filtered and concentrated. The residue was purified by column chromatography using dichloromethane as eluent to give 10.9 g (48.4% yield) of light yellow target product.1H NMR (CDCl3): δ 8.68 (s, 1H), 7.88 (m, 1H), 7.49 (d, J = 9.9 Hz, 1H).
References
[1] Patent: US2003/45546, 2003, A1
2-Iodo-5-trifluoromethylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
| Shanghai Longsheng chemical Co.,Ltd. | 58099637 13585536065 | sales@shlschem.com | China | 9880 | 59 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 |
View Latest Price from 2-Iodo-5-trifluoromethylpyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | 2-Iodo-5-trifluoromethylpyridine
100366-75-4
|
$1.10 | 1g | 99.00% | 100 Tons Min | Dideu Industries Group Limited | |
 |
2024-03-28 | 2-Iodo-5-(trifluoromethyl)pyridine
100366-75-4
|
25kg | 98% | PNP Biotech Co. Ltd | |||
 |
2020-02-02 | 2-Iodo-5-trifluoromethylpyridine
100366-75-4
|
$1.00 | 1KG | 97% | 200kg | Career Henan Chemical Co |
-
- 2-Iodo-5-trifluoromethylpyridine
100366-75-4
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- 2-Iodo-5-(trifluoromethyl)pyridine
100366-75-4
- $0.00
- 98%
- PNP Biotech Co. Ltd
-
- 2-Iodo-5-trifluoromethylpyridine
100366-75-4
- $1.00
- 97%
- Career Henan Chemical Co
