4-Cyanobenzenesulfonyl chloride 97
- CAS No.
- 49584-26-1
- Chemical Name:
- 4-Cyanobenzenesulfonyl chloride 97
- Synonyms
- 4-Cyanobenzenesulfonyl chloride;4-CYANOBENZENESULFON;C-Nitrile, S-chloride;4-(Chlorosulphonyl)benzonitrile;p-Cyanobenzenesulphonylchloride;4-(Chlorosulfonyl)-benzonitrile;p-Cyanobenzenesulfonyl chloride;4-Cyanobenzenesulphonyl chloride;paraCyanobenzene Sulfonyl Chloride;Benzenesulfonyl chloride, 4-cyano-
- CBNumber:
- CB8498797
- Molecular Formula:
- C7H4ClNO2S
- Molecular Weight:
- 201.63
- MDL Number:
- MFCD00052337
- MOL File:
- 49584-26-1.mol
- MSDS File:
- SDS
| Melting point | 107-111 °C (lit.) |
|---|---|
| Boiling point | 90-95 °C(Press: 3-4 Torr) |
| Density | 1.53±0.1 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| form | powder to crystal |
| color | White to Light yellow |
| Sensitive | Moisture Sensitive |
| BRN | 777939 |
| CAS DataBase Reference | 49584-26-1(CAS DataBase Reference) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314-H317 | |||||||||
| Precautionary statements | P260-P280-P301+P330+P331-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-43-29-20/21/22-14 | |||||||||
| Safety Statements | 26-36/37/39-45-30-22-8 | |||||||||
| RIDADR | UN 3261 8/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| Hazard Note | Corrosive | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29269090 | |||||||||
| NFPA 704 |
|
4-Cyanobenzenesulfonyl chloride 97 price More Price(45)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 638331 | 4-Cyanobenzenesulfonyl chloride 97% | 49584-26-1 | 1g | $43.2 | 2023-06-20 | Buy |
| Sigma-Aldrich | 638331 | 4-Cyanobenzenesulfonyl chloride 97% | 49584-26-1 | 5g | $78.9 | 2023-06-20 | Buy |
| TCI Chemical | C1813 | 4-Cyanobenzenesulfonyl Chloride >98.0%(GC)(T) | 49584-26-1 | 1g | $34 | 2026-04-30 | Buy |
| TCI Chemical | C1813 | 4-Cyanobenzenesulfonyl Chloride >98.0%(GC)(T) | 49584-26-1 | 5g | $107 | 2026-04-30 | Buy |
| Activate Scientific | AS32869 | 4-Cyanobenzenesulfonyl chloride 97% | 49584-26-1 | 1g | $27 | 2026-06-04 | Buy |
4-Cyanobenzenesulfonyl chloride 97 Chemical Properties, Uses, Production
Chemical Properties
Light orange solid
Uses
4-Cyanobenzenesulfonyl chloride is a useful research chemical compound used in the preparation of phenyldiazenyl-sulfonamides as aromatase inhibitors.
Synthesis
150993-53-6
49584-26-1
N-Chlorosuccinimide (NCS, 1.778 g, 13.32 mmol) was slowly added to a suspension of 4-(benzylthio)benzonitrile (1 g, 4.44 mmol) dissolved in acetic acid (AcOH, 10 mL) and water (3.5 mL) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with ethyl acetate (EtOAc), washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using a hexane solution of 15%-20% ethyl acetate as eluent to give a white solid. The resulting solid was washed with hexane and dried under reduced pressure to give 4-cyanobenzenesulfonyl chloride (0.701 g, 3.48 mmol, 78% yield) as a white solid. The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 7.91-7.97 (2H, m), 8.15-8.21 (2H, m).
References
[1] Patent: WO2018/30550, 2018, A1. Location in patent: Paragraph 0605
[2] Tetrahedron Letters, 2017, vol. 58, # 23, p. 2244 - 2247
4-Cyanobenzenesulfonyl chloride 97 Preparation Products And Raw materials
Raw materials
1of3
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Shanghai Sinch Parmaceuticals Tech. Co. Ltd. | +86-21-54098501 | sales@sinch.com.cn | China | 11592 | 64 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
View Latest Price from 4-Cyanobenzenesulfonyl chloride 97 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 4-CYANOBENZENESULFONYL CHLORIDE 97
49584-26-1
|
$1.00 | 1g | 99% | 200kg | Career Henan Chemical Co |
-
- 4-CYANOBENZENESULFONYL CHLORIDE 97
49584-26-1
- $1.00
- 99%
- Career Henan Chemical Co
