CHAETOMIN
- CAS No.
- 1403-36-7
- Chemical Name:
- CHAETOMIN
- Synonyms
- CTM;19A;CS-1;HSF4;SSFA2;CMH16;CRACC;C4orf5;UNQ576;PRO1138
- CBNumber:
- CB4173948
- Molecular Formula:
- C31H30N6O6S4
- Molecular Weight:
- 710.87
- MDL Number:
- MFCD28137713
- MOL File:
- 1403-36-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Chetomin from Chaetomium cochliodes, ≥98% (HPLC) | C9623 | 1mg | $292 |
| Chetomin from Chaetomium cochliodes, ≥98% (HPLC) | C9623 | 5mg | $874 |
| ANTI-HSF4 antibody produced in mouse clone 2A2, purified immunoglobulin, buffered aqueous solution | SAB1412167 | 100 μg | $541 |
| ANTI-HSF4 antibody produced in mouse clone 2B3, purified immunoglobulin, buffered aqueous solution | SAB1412151 | 100 μg | $541 |
| Monoclonal Anti-HSF4 antibody produced in mouse clone 3G3, purified immunoglobulin, buffered aqueous solution | SAB1403947 | 100μg | $541 |
| Melting point | 218-220℃ (chloroform ) |
|---|---|
| Density | 1.78±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: soluble |
| pka | 12.69±0.10(Predicted) |
| form | Off-white to fawn solid. |
| color | Off-white to fawn |
| biological source | mouse |
| InChIKey | ZRZWBWPDBOVIGQ-UHFFFAOYSA-N |
| SMILES | S1SC9(N(C(=O)C1(N(C9=O)C)CO)C)Cc2c3c([n](c2)C54C(N7C8(SSC(N(C8=O)C)(C7=O)CO)C5)Nc6c4cccc6)cccc3 |
| EWG's Food Scores | 1 |
| FDA UNII | BKU7CX6USX |
| UNSPSC Code | 41100000 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P301+P310 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25 | |||||||||
| Safety Statements | 45 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral | |||||||||
| Toxicity | rat,LD50,oral,75mg/kg (75mg/kg),"CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 174, 1980. | |||||||||
| NFPA 704 |
|
CHAETOMIN price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C9623 | Chetomin from Chaetomium cochliodes, ≥98% (HPLC) | 1403-36-7 | 1mg | $292 | 2026-04-30 | Buy |
| Sigma-Aldrich | C9623 | Chetomin from Chaetomium cochliodes, ≥98% (HPLC) | 1403-36-7 | 5mg | $874 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB1412167 | ANTI-HSF4 antibody produced in mouse clone 2A2, purified immunoglobulin, buffered aqueous solution | 100 μg | $541 | 2025-07-31 | Buy | |
| Sigma-Aldrich | SAB1412151 | ANTI-HSF4 antibody produced in mouse clone 2B3, purified immunoglobulin, buffered aqueous solution | 100 μg | $541 | 2025-07-31 | Buy | |
| Sigma-Aldrich | SAB1403947 | Monoclonal Anti-HSF4 antibody produced in mouse clone 3G3, purified immunoglobulin, buffered aqueous solution | 1403-36-7 | 100μg | $541 | 2025-07-31 | Buy |
CHAETOMIN Chemical Properties,Uses,Production
Uses
Chetomin is an antibacterial agent and inhibitor of HIF.
Definition
ChEBI: An organic heteropentacyclic compound of the class of epipolythiodioxopiperazine. Isolated from Chaetomium globosum and Farrowia seminuda, it exhibits immunosuppressive activity.
Biochem/physiol Actions
Chetomin is a natural metabolite produced by several species of the genus Chaetomium. Chetomin is an epidithiodioxopiperazine known to disrupt the hypoxia-inducible factor (HIF) pathway. Chetomin blocks the interaction of HIF1α and HIF2α with transcriptional co-activators p300 and cAMP response element binding (CREB) binding protein (CBP), thereby attenuating hypoxia-inducible transcription. Disrupting the ability of tumors to adapt to hypoxia leads to decreased tumor growth and can serve as an antitumor stratagy. Chetomin also suppresses the proliferation of LPS-induced mouse spleen lymphocytes.
in vivo
Chetomin (0~100 mg/kg; p.o.) inhibits lung tumorigenesis in NSCLC mouse models[1].
Chetomin markedly decreases tumor formation in several murine models of NSCLC[1].
| Animal Model: | Mouse |
| Dosage: | 0~100 mg/kg |
| Administration: | P.o. |
| Result: | Inhibited lung tumorigenesis in NSCLC mouse models. |
IC 50
HSP90
storage
+4°C
CHAETOMIN Preparation Products And Raw materials
Raw materials
Preparation Products
CHAETOMIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39040 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +8613382787392 | sales@aeechem.com | China | 10000 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532; 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35896 | 56 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939; 15221275939 | shenlinxing@macklin.cn | China | 15781 | 55 |
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