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(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane structure

CAS No.: 113451-59-5

Chemical Name:: (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane

Synonyms: EOS-61878;(1S,4S)-5-Boc-2,5-diazabicyclo[2.2.1]heptane;(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane;(1S,4S)-N-BOC-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE;(1S,4S)-2-T-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE;(1S,4S)-(-)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE;(1S,4S)-2-N-T-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE;(1S,4S)-2-Boc-2,5-diazabicyclo2.2.1üheptane, 97%;(1S,4S)-2,5-Diazabicyclo(2,2,1)Heptane-2-Carboxylate;(1S,4S)-(-)-2-BOC-2,5-diazabicyclo[2.2.1]heptane,95%

CBNumber:: CB7158599

Molecular Formula:: C10H18N2O2

Molecular Weight:: 198.26

MDL Number:: MFCD01569250

MOL File:: 113451-59-5.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:54:40

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(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane Properties

Melting point	74-76 °C(lit.)
alpha	-44o (C=1 IN CHLOROFORM)
Boiling point	276.4±15.0 °C(Predicted)
Density	1.104±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
form	Powder
pka	9.74±0.20(Predicted)
color	White to slightly beige
optical activity	[α]22/D 44°, c = 1 in chloroform
Water Solubility	Insoluble in water.
Sensitive	Air Sensitive
BRN	6460311
InChI	InChI=1S/C10H18N2O2/c1-10(2,3)14-9(13)12-6-7-4-8(12)5-11-7/h7-8,11H,4-6H2,1-3H3/t7-,8-/m0/s1
InChIKey	UXAWXZDXVOYLII-YUMQZZPRSA-N
SMILES	[C@]12([H])C[C@]([H])(NC1)CN2C(OC(C)(C)C)=O
CAS DataBase Reference	113451-59-5(CAS DataBase Reference)
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P280-P305+P351+P338-P309-P310

Risk Statements

Safety Statements

22-24/25-45-36/37/39-26

RIDADR

3263

WGK Germany

HS Code

29335990

Storage Class

11 - Combustible Solids

NFPA 704

	1
2		0

(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane price More Price(68)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	473049	(1S,4S)-(?)-2-Boc-2,5-diazabicyclo[2.2.1]heptane 95%	113451-59-5	1g	$198	2026-04-30	Buy
Sigma-Aldrich	473049	(1S,4S)-(?)-2-Boc-2,5-diazabicyclo[2.2.1]heptane 95%	113451-59-5	5g	$559	2026-04-30	Buy
TCI Chemical	D6152	tert-Butyl (1S,4S)-2,5-Diazabicyclo[2.2.1]heptane-2-carboxylate min. 98.0 %	113451-59-5	1G	$77	2026-04-30	Buy
Usbiological	261699	(1S,4S)-N-Boc-2,5-diazabicyclo[2.2.1]heptane ≥98%	113451-59-5	1g	$355	2026-06-03	Buy
Usbiological	261699	(1S,4S)-N-Boc-2,5-diazabicyclo[2.2.1]heptane ≥98%	113451-59-5	5g	$708	2026-06-03	Buy

Product number	Packaging	Price	Buy
473049	1g	$198	Buy
473049	5g	$559	Buy
D6152	1G	$77	Buy
261699	1g	$355	Buy
261699	5g	$708	Buy

(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane Chemical Properties, Uses, Production

Chemical Properties

White to slightly beige powder

Uses

It is used as an active pharmaceutical intermediate.

Synthesis

1-Pyrrolidinecarboxylic acid, 2-(azidomethyl)-4-[(methylsulfonyl)oxy]-, 1,1-dimethylethyl ester, (2S,4R)-

113451-54-0

(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE

113451-59-5

Methylsulfonate 17 (1.2 g, 3.78 mmol) was used as raw material, which was suspended in anhydrous THF (38 mL), triphenylphosphine (1.48 g, 5.66 mmol) was added, and the reaction was stirred at room temperature for 2 hours. Subsequently, H2O (0.5 mL) was added and stirring was continued for 18 hours. Upon completion of the reaction, the solvent was removed under reduced pressure and the residue was suspended in 1 M hydrochloric acid (150 mL) and extracted with CH2Cl2 (2 x 70 mL). The aqueous layer was adjusted to pH 14 with base and then extracted with CH2Cl2 (3 × 70 mL). The organic phases were combined, washed with brine (100 mL), dried over anhydrous MgSO4 and concentrated under reduced pressure. Purification by rapid chromatography on silica gel with the eluent CH2Cl2-methanol-ammonia (90:9:1) afforded the target product amine 18 (0.52 g, 2.62 mmol, 71% yield) as a colorless solid. The product characterization data were as follows: melting point 76.8-77.9 °C; specific spin [α]D -47.6 (c 1.0, CHCl3); IR spectra (νmax/cm-1) 2975, 1688, 1408, 1170; 1H NMR (500 MHz, CDCl3) δ 4.43 (0.5H, s), 4.30 (0.5H, s), 3.69 (1H, s), 3.38-3.32 (1H, m), 3.19-3.13 (1H, m), 3.06-2.97 (2H, m), 1.75-1.65 (2H, m), 1.45-1.43 (9H, m); 13C NMR (125 MHz, CDCl3) δ 154.6, 154.3, 79.6, 79.5, 57.3, 56.6, 56.5, 56.3, 56.1, 52.8, 52.7, 37.2, 37.0, 28.66; mass spectra (APCI) m/z 199 ([M+H]+, 100).

References

[1] Journal of Organic Chemistry, 1988, vol. 53, # 7, p. 1580 - 1582
[2] Tetrahedron Letters, 2013, vol. 54, # 39, p. 5345 - 5347

(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane Preparation Products And Raw materials

Raw materials

(1S,4S)-tert-butyl 5-benzyl-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (2S,4S)-1-Boc-2-hydroxymethyl-4-amino pyrrolidine-HCl 1-Pyrrolidinecarboxylic acid, 2-(azidomethyl)-4-[(methylsulfonyl)oxy]-, 1,1-dimethylethyl ester, (2S,4R)- Triphenylphosphine Tetrahydrofuran

Preparation Products

1-((1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-yl)ethan-1-one hydrochloride

(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane Suppliers

Global Suppliers ( 230)

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Join Biological Pharmaceutical Co., Ltd.	13818361018	shzuolin@163.com	China	49	50
Chengdu Dorher Pharmaceutical CO.,Ltd	028-64259743 19983537320	wangmin@focuspharm.com	China	498	58
Chengdu Firster Pharmaceutical Co., Ltd.	19138996873	670603485@qq.com	China	196	58
Jiangxi Youken Biotechnology Co., Ltd.	15107073929	1150046738@qq.com	China	464	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Ark Pharm, Inc.	847-367-3680	sales@arkpharminc.com	United States	1669	56
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56

Supplier	Advantage
Shanghai Join Biological Pharmaceutical Co., Ltd.	50
Chengdu Dorher Pharmaceutical CO.,Ltd	58
Chengdu Firster Pharmaceutical Co., Ltd.	58
Jiangxi Youken Biotechnology Co., Ltd.	58
J & K SCIENTIFIC LTD.	76
Chembest Research Laboratories Limited	61
Alfa Aesar	84
Ark Pharm, Inc.	56
Energy Chemical	61
Wuhan Chemwish Technology Co., Ltd	56

View Latest Price from (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	(1S,4S)-()-2-Boc-2,5-diazabicyclo[2.2.1]heptane 113451-59-5	$10.00-15.00	1KG	99%+ HPLC		Zhuozhou Wenxi import and Export Co., Ltd
	2019-07-06	(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE 113451-59-5	$1.00	1kg	98%min	500kg	Career Henan Chemical Co

(1S,4S)-()-2-Boc-2,5-diazabicyclo[2.2.1]heptane
113451-59-5
$10.00-15.00
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE
113451-59-5
$1.00
98%min
Career Henan Chemical Co

(1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane Spectrum

(1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE(113451-59-5)¹HNMR (1S,4S)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE(113451-59-5)IR

113451-59-5 ((1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane) Related Search:

1-Boc-3-Methylaminopyrrolidine tert-Butyl 3-aminopyrrolidine-1-carboxylate (S)-3-(Boc-amino)pyrrolidine (S)-1-N-Boc-2-methylpiperazine 2-Boc-aminomethylpyrrolidine

2-(Aminomethyl)-1-N-Boc-pyrrolidine 1-Boc-2-Methylpiperazine 1-Boc-piperazine acetate (3S)-(-)-3-(Dimethylamino)pyrrolidine (S)-2-(Aminomethyl)-1-(tert-butoxycarbonyl)pyrrolidine

Heptane 4-N-Boc-2-Methyl-piperazine 2-Methylpiperazine (S)-1-Boc-3-methylpiperazine (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine

3-N-Boc-aminopyrrolidine (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane 3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine

1of4

TERT-BUTYL (1S, 4S)-(-)-2,5-DIAZABICYCLO[2.2.1]HEPTANE-2-CARBOXYLATE TERT-BUTYL (1S,4S)-2,5-DIAZABICYCLO(2.2.1)HEPTANE-2-CARBOXYLATE (1S,4S)-N-(TERT-BUTOXYCARBONYL)-2,5-DIAZABICYCLO[2.2.1]HEPTANE (1S,4S)-(-)-2-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE (1S,4S)-2-T-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE (1S,4S)-2-N-T-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE (1S,4S)-N-BOC-2,5-DIAZA-BICYCLO[2.2.1]HEPTANE N-(tert-Butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane~tert-Butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (1S,4S)-2,5-Diazabicyclo(2,2,1)Heptane-2-Carboxylate (1R,4R)-2-N-t-BOC-2,5-Diazabicyclo[2.2.1]heptane HBr 1,1-DIMETHYLETHYL (1S,4S)-2,5-DIAZABICYCLO(2.2.1)HEPTANE-2-CARBOXYLATE n-(tert-butoxycarbonyl)-2,5-diazabicyclo[2.2.1]heptane (1S,4S)-2-Boc-2,5-diazabicyclo2.2.1üheptane, 97% (1S,4S)-2-N-T-BOC-2,5-DIAZABICYCLO[2.2.1]HEPTANE HYDROBROMIDE (1S,4S)-tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate (1S,4S)-(-)-2-BOC-2,5-diazabicyclo[2.2.1]heptane,95% tert-Butyl (1S,4S)-2,5-diazabicyclo[2.2.1]heptan-2-carboxylate (1S,4S)-tert-butyl 2,5-diazabicyclo[2.2.1]heptane-2-carboxylate hydrochloride 2,5-Diazabicyclo[2.2.1]heptane-2-carboxylicacid, 1,1-diMethylethyl ester (1S,4S)-5-Boc-2,5-diazabicyclo[2.2.1]heptane (1S,4S)-2,5-DIAZA-BICYCLO(2.2.1)HEPTANE-2-CARBOXYLICACIDTERT-BUTYLESTER EOS-61878 (1S,4S)-(-)-2-Boc-2,5-diazabicyclo[2.2.1]heptane 95% 2,5-Diazabicyclo[2.2.1]heptane-2-carboxylicacid, 1,1-dimethylethyl ester, (1S,4S)- (1S,4S)-2-Boc-2,5-diazabicyclo(2.2.1)heptane methanesulfonic acid salt (1S,4S)-(?)-2-Boc-2,5-diazabicyclo[2.2.1]heptane (1S,4S)-N-Boc-2,5-diazabicyclo[2.2.1]heptane - [B6590] (1S,4S)-2-Boc-2,5-diazabicyclo[2.2.1]heptane 113451-59-5 C10H20Br2N2O2 Chiral Building Blocks Asymmetric Synthesis Heterocyclic Building Blocks Others Heterocycle-other series