2-Fluorophenylboronic acid
- CAS No.
- 1993-03-9
- Chemical Name:
- 2-Fluorophenylboronic acid
- Synonyms
- 2-Fluorophenylboronic;2-Flurorphenylboronic acid;2-FLUOROBENZENEBORONIC ACID;AKOS BRN-0104;2-fluoroborate;RARECHEM AH PB 0215;2-Fluorophenylboroni;o-Fluorphenylborsaeure;Tavaborole Impurity 30;uorobenzeneboronic acid
- CBNumber:
- CB4153982
- Molecular Formula:
- C6H6BFO2
- Molecular Weight:
- 139.92
- MDL Number:
- MFCD00674013
- MOL File:
- 1993-03-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 101-110 °C (lit.) |
|---|---|
| Boiling point | 267.8±42.0 °C(Predicted) |
| Density | 1.24±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | soluble in Methanol |
| pka | 8.32±0.58(Predicted) |
| form | Crystalline Powder |
| color | White to light yellow |
| BRN | 3030413 |
| InChI | InChI=1S/C6H6BFO2/c8-6-4-2-1-3-5(6)7(9)10/h1-4,9-10H |
| InChIKey | QCSLIRFWJPOENV-UHFFFAOYSA-N |
| SMILES | B(C1=CC=CC=C1F)(O)O |
| CAS DataBase Reference | 1993-03-9(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xn,Xi | |||||||||
| Risk Statements | 36/37/38-22 | |||||||||
| Safety Statements | 37/39-26-36/37/39-27-24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29319090 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
2-Fluorophenylboronic acid price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 445223 | 2-Fluorophenylboronic acid ≥95% | 1993-03-9 | 1g | $73.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | 445223 | 2-Fluorophenylboronic acid ≥95% | 1993-03-9 | 10g | $657 | 2026-04-30 | Buy |
| TCI Chemical | F0407 | 2-Fluorophenylboronic Acid (contains varying amounts of Anhydride) | 1993-03-9 | 1g | $25 | 2026-04-30 | Buy |
| TCI Chemical | F0407 | 2-Fluorophenylboronic Acid (contains varying amounts of Anhydride) | 1993-03-9 | 5g | $72 | 2026-04-30 | Buy |
| Usbiological | 276070 | 2-Fluorophenylboronic acid Asreported | 1993-03-9 | 5g | $365 | 2026-06-03 | Buy |
2-Fluorophenylboronic acid Chemical Properties, Uses, Production
Chemical Properties
white to light yellow crystalline powder
Uses
suzuki reaction
Uses
2-Fluorophenylboronic Acid, is used in Rh-catalyzed enantioselective addition reactions, and Rhodium and Palladium-catalyzed substitution reactions. It can also be used in the preparation of phenylboronic catechol esters as promising anion receptors for polymer electrolytes.
Uses
Used for the preparation of biologically active biphenyls and arylboron difluoride Lewis acids.
Synthesis
1072-85-1
1993-03-9
The general procedure for the synthesis of 2-fluorophenylboronic acid from o-bromofluorobenzene was as follows: 10.0 g (57.1 mmol) of 1-bromo-2-fluorobenzene and anhydrous tetrahydrofuran were added to a reaction flask and the mixture was subsequently cooled to -70 °C. At -70 °C, 44.2 ml (68.5 mmol) of 1.55 M n-butyllithium solution was slowly added dropwise to the reaction mixture. The temperature was maintained at -70 °C and stirring of the reaction mixture was continued for 1.5 hours. Subsequently, 21.5 g (114.2 mmol) of triisopropyl borate was added dropwise and the reaction temperature was gradually raised to room temperature and stirring was continued for 4 hours. Upon completion of the reaction, aqueous hydrochloric acid was added to the reaction mixture and extracted with dichloromethane. The organic phases were combined and the solvent was removed by distillation under reduced pressure to give the crude product of 2-fluorophenylboronic acid. The crude product was purified by column chromatography (eluent: hexane/acetone) to give 4.8 g (yield: 61%) of pure 2-fluorophenylboronic acid.
References
[1] Patent: US2012/273770, 2012, A1. Location in patent: Page/Page column 24
[2] Patent: US2004/6076, 2004, A1. Location in patent: Page 15
[3] Journal of Organic Chemistry, 2013, vol. 78, # 13, p. 6427 - 6439
2-Fluorophenylboronic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Tianjin Xinshengjiahe Technology Development Co., Ltd. | 022-83719186 13212251377 | 18522618860@163.com | China | 82 | 55 |
| Shandong Binchen Chemical Co.，Ltd | 13837799094 18351216136 | 3846935277@qq.com | China | 2631 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from 2-Fluorophenylboronic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 2-Fluorophenylboronic acid
1993-03-9
|
$30.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2024-11-07 | 2-Fluorophenylboronic acid
1993-03-9
|
$5.00 | 1kg | 99% | 200000 | Hebei Jingbo New Material Technology Co., Ltd | |
 |
2022-10-09 | 2-Fluorophenylboronic acid
1993-03-9
|
$30.00-150.00 | 100Kg | 99.0% up | 50 tons per month | Xinxiang Hongqi District Houyuan Trading Co.,Ltd |
-
- 2-Fluorophenylboronic acid
1993-03-9
- $30.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 2-Fluorophenylboronic acid
1993-03-9
- $5.00
- 99%
- Hebei Jingbo New Material Technology Co., Ltd
-
- 2-Fluorophenylboronic acid
1993-03-9
- $30.00-150.00
- 99.0% up
- Xinxiang Hongqi District Houyuan Trading Co.,Ltd
