2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine
- CAS No.
- 33252-64-1
- Chemical Name:
- 2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine
- Synonyms
- 5-NITRO-3-(TRIFLUOROMETHYL)PYRIDIN-2-OL;3-NITRO-5-(TRIFLUOROMETHYL)PYRIDIN-2-OL;BUTTPARK 25\01-34;2-hydroxy-3-nitro-5-trifluoropyridine;3-Nitro-5-(trifluoroMethyl)pyridin-2-o;5-NITRO-3-(TRIFLUOROMETHYL-2-PYRIDONE);3-NITRO-5-(TRIFLUOROMETHYL)-2-PYRIDONE;3-NITRO-5-TRIFLUOROMETHYL-2-PYRIDINONE;5-(trifluoromethyl)-3-nitropyridin-2-ol;3-Nitro-5-(trifluoromethyl)-2-pyridinol
- CBNumber:
- CB8395090
- Molecular Formula:
- C6H3F3N2O3
- Molecular Weight:
- 208.09
- MDL Number:
- MFCD00764318
- MOL File:
- 33252-64-1.mol
- MSDS File:
- SDS
| Melting point | 189 °C |
|---|---|
| Boiling point | 276.2±40.0 °C(Predicted) |
| Density | 1.61±0.1 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| pka | 5.89±0.10(Predicted) |
| form | Solid |
| color | Off-white |
| InChI | InChI=1S/C6H3F3N2O3/c7-6(8,9)3-1-4(11(13)14)5(12)10-2-3/h1-2H,(H,10,12) |
| InChIKey | JYXKHKBZLLIWEV-UHFFFAOYSA-N |
| SMILES | C1(=O)NC=C(C(F)(F)F)C=C1[N+]([O-])=O |
| CAS DataBase Reference | 33252-64-1(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H312-H315-H319-H332-H335 | |||||||||
| Precautionary statements | P261-P280-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 22-26-36/37/39 | |||||||||
| RIDADR | NA3077 | |||||||||
| Hazard Note | Irritant | |||||||||
| HazardClass | 6.1 | |||||||||
| HS Code | 2933399990 | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Non-Hazardous | |||||||||
| NFPA 704 |
|
2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine price More Price(63)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| AstaTech | 64919 | 3-NITRO-5-TRIFLUOROMETHYL-2-PYRIDINONE 97% | 33252-64-1 | 1G | $21 | 2026-04-30 | Buy |
| Apolloscientific | PC4861 | 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine 98% | 33252-64-1 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | PC4861 | 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine 98% | 33252-64-1 | 5g | $62 | 2026-06-04 | Buy |
| Apolloscientific | PC4861 | 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine 98% | 33252-64-1 | 25g | $184 | 2026-06-04 | Buy |
| Matrix Scientific | 001464 | 2-Hydroxy-3-nitro-5-(trifluoromethyl)pyridine | 33252-64-1 | 10.00g | $80 | 2026-05-18 | Buy |
2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine Chemical Properties, Uses, Production
Synthesis
33252-63-0
33252-64-1
The general procedure for the synthesis of 2-hydroxy-3-nitro-5-trifluoromethylpyridine using 2-hydroxy-5-trifluoromethylpyridine as starting material was as follows: 2-hydroxy-5-trifluoromethylpyridine (10.0 g, 61.3 mmol) was dissolved in concentrated sulfuric acid (50 mL), and the reaction system was cooled to 0 °C. Fuming nitric acid (14 mL, 92 mmol) was slowly added dropwise at 0 °C. After the dropwise addition, the reaction was kept at 0 °C and continued to be stirred for 1 h. Subsequently, the temperature of the reaction was raised to 65 °C and the reaction was continued to be stirred for 24 h. The reaction temperature was increased to 65 °C and the reaction was continued to be stirred. After completion of the reaction, the reaction system was cooled to room temperature and the reaction was quenched by slowly pouring into ice (300 g). Subsequently, 50% aqueous sodium hydroxide solution (85 mL) was slowly added to neutralize the reaction mixture. The aqueous phase was extracted several times with ethyl acetate (4 x 200 mL), all organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give a yellow solid 2-hydroxy-3-nitro-5-trifluoromethylpyridine 7.4 g in 58% yield. The product was characterized by 1H NMR (CDCl3): δ 8.66 (s, 1H), 8.29 (s, 1H).
References
[1] Patent: WO2009/7418, 2009, A1. Location in patent: Page/Page column 23
[2] Patent: CN105111209, 2017, B. Location in patent: Paragraph 0029; 0036
[3] Patent: US2006/4018, 2006, A1. Location in patent: Page/Page column 14; 35
[4] Patent: WO2011/43404, 2011, A1. Location in patent: Page/Page column 111-112
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 13, p. 3983 - 3987
2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Harvest Chemical Industrial Co., Ltd. | 15721252604 17321035817 | sales@harvest-chem.com | China | 2829 | 64 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| ShangHai DEMO Chemical Co.,Ltd | 400-021-7337 2355568890 | sales@demochem.com | China | 2569 | 57 |
| Beijing HwrkChemical Technology Co., Ltd | 89508211 18501085097 | sales.bj@hwrkchemical.com | China | 9407 | 55 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Nan Jing Dirise Chemcial Co.,LTD | 025-52161033 15312098939 | 2432674894@qq.com | China | 585 | 64 |
| Beijing Isomersyn Technology CO;LTD | 010-82954736 13391601435 | sales@isomersyn.com | China | 3294 | 57 |
View Latest Price from 2-Hydroxy-5-nitro-3-(trifluoromethyl)pyridine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-25 | 3-Nitro-5-(trifluoromethyl)-2-pyridinol
33252-64-1
|
$1.10-9.90 | 1KG | 99% min | 100kg | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | |
 |
2026-08-01 | 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
33252-64-1
|
1kg | 98% | 1000kgs | Shaanxi Dideu New Materials Co. Ltd | ||
 |
2025-12-24 | 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
33252-64-1
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
-
- 3-Nitro-5-(trifluoromethyl)-2-pyridinol
33252-64-1
- $1.10-9.90
- 99% min
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
-
- 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
33252-64-1
- $0.00
- 98%
- Shaanxi Dideu New Materials Co. Ltd
-
- 2-HYDROXY-5-NITRO-3-(TRIFLUOROMETHYL)PYRIDINE
33252-64-1
- $0.10
- 99.0%
- Shaanxi Dideu Medichem Co. Ltd
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