1-Hydroxypiperidine
- CAS No.
- 4801-58-5
- Chemical Name:
- 1-Hydroxypiperidine
- Synonyms
- Hydroxypiperidine;1-piperidinol;piperidin-1-ol;1-HYDROXYPIPERDINE;1-hydroxy-piperidin;N-HYDROXYPIPERIDINE;1-Hydroxypiperidine;Piperidine, 1-hydroxy-;Bupivacaine Impurity 27;1-HYDROXYPIPERIDINE 96+%
- CBNumber:
- CB4185440
- Molecular Formula:
- C5H11NO
- Molecular Weight:
- 101.15
- MDL Number:
- MFCD00038048
- MOL File:
- 4801-58-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 37-39 °C |
|---|---|
| Boiling point | 146-148℃ (1 Torr) |
| Density | 0.9903 (rough estimate) |
| refractive index | 1.4550 (estimate) |
| Flash point | 78 °C |
| storage temp. | 2-8°C |
| pka | 14.19±0.20(Predicted) |
| form | low melting solid |
| color | White |
| BRN | 102726 |
| InChI | 1S/C5H11NO/c7-6-4-2-1-3-5-6/h7H,1-5H2 |
| InChIKey | LKPFBGKZCCBZDK-UHFFFAOYSA-N |
| SMILES | ON1CCCCC1 |
| EWG's Food Scores | 1 |
| FDA UNII | 9ANQ5DB3A2 |
| EPA Substance Registry System | Piperidine, 1-hydroxy- (4801-58-5) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| WGK Germany | 3 |
| RTECS | TN6829550 |
| F | 3-10 |
| TSCA | TSCA listed |
| HS Code | 2933399990 |
| Storage Class | 11 - Combustible Solids |
1-Hydroxypiperidine price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 56207 | 1-Hydroxypiperidine ≥96.0% (GC) | 4801-58-5 | 1g | $155 | 2026-04-30 | Buy |
| AstaTech | 65654 | 1-PIPERIDINOL 95% | 4801-58-5 | 0.25G | $80 | 2026-04-30 | Buy |
| AstaTech | 65654 | 1-PIPERIDINOL 95% | 4801-58-5 | 1G | $183 | 2026-04-30 | Buy |
| Apolloscientific | OR961933 | 1-Hydroxypiperidine >96% | 4801-58-5 | 100mg | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR961933 | 1-Hydroxypiperidine >96% | 4801-58-5 | 250mg | $33 | 2026-06-04 | Buy |
1-Hydroxypiperidine Chemical Properties,Uses,Production
Chemical Properties
Soluble in water, organic solvents, aqueous acids, and bases.
Uses
Base for Fmoc-based solid phase peptide synthesis
Light stabilizing agent
Uses
Base for Fmoc-based solid phase peptide synthesis1Light stabilizing agent2
Synthesis Reference(s)
The Journal of Organic Chemistry, 53, p. 5856, 1988 DOI: 10.1021/jo00260a012
Synthesis
110-89-4
4801-58-5
General procedure for the synthesis of N-hydroxypiperidine from hexahydropyridine: hexahydropyridine (5 mmol) and ChPS (5.5 mmol) were added to a round-bottomed flask under nitrogen protection, and the reaction was stirred for 1 hr at 60 °C. After completion of the reaction, the mixture was dissolved in water (5 mL) and the product was extracted with dichloromethane or ethyl acetate (5 mL each time, 3 times). The organic layers were combined, dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give the target product N-hydroxypiperidine.
References
[1] Synlett, 2017, vol. 28, # 17, p. 2315 - 2319
[2] Tetrahedron Letters, 2001, vol. 42, # 20, p. 3419 - 3422
[3] Justus Liebigs Annalen der Chemie, 1948, vol. 559, p. 1,22, 23
[4] Chemische Berichte, 1951, vol. 84, p. 690,698
[5] Chemische Berichte, 1892, vol. 25, p. 2782
1-Hydroxypiperidine Preparation Products And Raw materials
1-Hydroxypiperidine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Zhengzhou Kingsfine Chemical Co., Ltd. | 0371-56635027 13838252817 | sales@kingsfine.com | China | 100 | 62 |
| Beijing Taiya Jie Technology Development Co., Ltd. | 021-33690831-8001 13552411790;18616022633 | postmaster@tyjchem.cn | China | 1541 | 55 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Huainan Kedi Chemical Factory | 0554-2106669 | sales1@kedichem.com | China | 4914 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7717 | 56 |
| Chengdu HuaXia Chemical Reagent Co. Ltd | 400-1166-196 13458535857 | cdhxsj@163.com | China | 13323 | 58 |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9985 | 58 |
View Lastest Price from 1-Hydroxypiperidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-09 | 1-HYDROXYPIPERIDINE
4801-58-5
|
$9.80 | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- 1-HYDROXYPIPERIDINE
4801-58-5
- $9.80
- ≥99%
- Career Henan Chemical Co
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