(R)-1-Boc-3-methylpiperazine
- CAS No.
- 163765-44-4
- Chemical Name:
- (R)-1-Boc-3-methylpiperazine
- Synonyms
- tert-butyl (R)-3-methylpiperazine-1-carboxylate;(R)-tert-butyl 3-Methylpiperazine-1-carboxylate;(R)-4-BOC-2-METHYLPIPERAZINE;(R)-4-N-BOC-2-METHYLPIPERAZINE;CAS:163765-44-4;tert-Butyl (3R)-3-methylpiperazine-1-carboxylate;(R)-4-Boc-2-Methylpi;(R)-N-BOC-2-METHYLPIPERAZINE;(R)-1-BOC-3-METHYLPIPERAZINE;(R)-N4-BOC-2-METHYLPIPERAZINE
- CBNumber:
- CB4192376
- Molecular Formula:
- C10H20N2O2
- Molecular Weight:
- 200.28
- MDL Number:
- MFCD02683205
- MOL File:
- 163765-44-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 40-45 °C |
|---|---|
| Boiling point | 268.7±15.0 °C(Predicted) |
| Density | 0.997±0.06 g/cm3(Predicted) |
| Flash point | 223 °F |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| pka | 8.52±0.40(Predicted) |
| form | Crystalline Powder |
| color | White |
| optical activity | [α]/D +16±2°, c = 1 in dioxane |
| InChI | InChI=1S/C10H20N2O2/c1-8-7-12(6-5-11-8)9(13)14-10(2,3)4/h8,11H,5-7H2,1-4H3/t8-/m1/s1 |
| InChIKey | FMLPQHJYUZTHQS-MRVPVSSYSA-N |
| SMILES | N1(C(OC(C)(C)C)=O)CCN[C@H](C)C1 |
| CAS DataBase Reference | 163765-44-4(CAS DataBase Reference) |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 37/38-41-36/37/38 | |||||||||
| Safety Statements | 26-39-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-34 | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Eye Irrit. 2 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
(R)-1-Boc-3-methylpiperazine price More Price(82)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | M3462 | (R)-1-Boc-3-methylpiperazine min. 98.0 % | 163765-44-4 | 5G | $41 | 2026-04-30 | Buy |
| TCI Chemical | M3462 | (R)-1-Boc-3-methylpiperazine min. 98.0 % | 163765-44-4 | 25G | $125 | 2026-04-30 | Buy |
| AstaTech | 56832 | (R)-4-N-BOC-2-METHYL-PIPERAZINE 98% | 163765-44-4 | 5G | $29 | 2026-04-30 | Buy |
| AstaTech | 56832 | (R)-4-N-BOC-2-METHYL-PIPERAZINE 98% | 163765-44-4 | 25G | $67 | 2026-04-30 | Buy |
| AstaTech | 56832 | (R)-4-N-BOC-2-METHYL-PIPERAZINE 98% | 163765-44-4 | 100G | $200 | 2026-04-30 | Buy |
(R)-1-Boc-3-methylpiperazine Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
(R)-4-Boc-2-methylpiperazine is a reagent used in organic synthesis. Used in the synthesis of orally bioavailable inhibitors of 11-β-hydroxysteroid. (R)-4-Boc-2-methylpiperazine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Synthesis
To a solution of (R)-methylpiperazine (400 mg) in dichloromethane (20 mL) at 0 ℃ was added di-tert-butyl dicarbonate (871 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL), followed by extraction into dichloromethane (2 x 40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4), and concentrated to give (R)-1-Boc-3-methylpiperazine as a white solid (669 mg, 84%).
References
[1] Patent: WO2008/70740, 2008, A1. Location in patent: Page/Page column 191
[2] Patent: US2010/216812, 2010, A1. Location in patent: Page/Page column 45
[3] Patent: US2011/201622, 2011, A1. Location in patent: Page/Page column 14
[4] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 11, p. 3282 - 3285
[5] Patent: US2005/70549, 2005, A1
(R)-1-Boc-3-methylpiperazine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Koma Biotechnology Co., Ltd. | 15549418308 | 345969539@qq.com | China | 77 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Sichuan Tongsheng Amino acids Co.,Ltd. | 0838-2274206 17340404235 | sales@biots.cn | China | 300 | 66 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Wuhan Chemwish Technology Co., Ltd | 86-027-67849912 | sales@chemwish.com | China | 35884 | 56 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
View Lastest Price from (R)-1-Boc-3-methylpiperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | (R)-4-Boc-2-methylpiperazine
163765-44-4
|
$37.00-788.00 | 10g | 0.99 | 25kg | Shanghai UCHEM Inc. | |
 |
2022-02-10 | (R)-4-N-Boc-2-methylpiperazine
163765-44-4
|
1KG | 99.3% | 100 tons | Honest Joy Holdings Limited | ||
 |
2019-07-06 | (R)-4-Boc-2-methylpiperazine
163765-44-4
|
$2.00 | 1kg | 99% | Career Henan Chemical Co |
-
- (R)-4-Boc-2-methylpiperazine
163765-44-4
- $37.00-788.00
- 0.99
- Shanghai UCHEM Inc.
-
- (R)-4-N-Boc-2-methylpiperazine
163765-44-4
- $0.00
- 99.3%
- Honest Joy Holdings Limited
-
- (R)-4-Boc-2-methylpiperazine
163765-44-4
- $2.00
- 99%
- Career Henan Chemical Co
