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(R)-(-)-2-Methylpiperazine

(R)-(-)-2-Methylpiperazine structure

CAS No.: 75336-86-6

Chemical Name:: (R)-(-)-2-Methylpiperazine

Synonyms: R-MP;NNX3;URI1;C19orf2;PPP1R19;(R)-2-methylpiperadine;(R)-2-METHYLPIPERAZINE;(2R)-2-Methylpiperazine;Phenylephrine Impurity 84;(R)-(-)-2-METHYLPIPERAZINE

CBNumber:: CB9445086

Molecular Formula:: C5H12N2

Molecular Weight:: 100.16

MDL Number:: MFCD00192317

MOL File:: 75336-86-6.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-04-24 14:58:50

Product description	Number	Pack Size	Price
(R)-(?)-2-Methylpiperazine 97%	397164	1g	$50.2
ANTI-RMP (URI)(C-TERMINAL) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution	SAB1305286	400μL	$461
(R)-(-)-2-Methylpiperazine >98.0%(GC)(T)	M2091	5g	$119
(R)-(-)-2-Methylpiperazine >98.0%(GC)(T)	M2091	25g	$378
(R)-2-METHYLPIPERAZINE 98%	29365	5G	$11
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(R)-(-)-2-Methylpiperazine Properties

Melting point	91-93 °C (lit.)
alpha	-18 º (c=1, toluene)
Boiling point	155-156 °C
Density	0.9305 (estimate)
refractive index	1.4378 (estimate)
Flash point	149 °F
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
pka	9.31±0.40(Predicted)
form	Crystalline Powder, Crystals and/or Chunks
color	White to yellow
optical activity	[α]20/D 16.5°, c = 5 in benzene
Water Solubility	soluble
Sensitive	Air Sensitive & Hygroscopic
BRN	3647994
InChI	1S/C5H12N2/c1-5-4-6-2-3-7-5/h5-7H,2-4H2,1H3/t5-/m1/s1
InChIKey	JOMNTHCQHJPVAZ-RXMQYKEDSA-N
SMILES	C[C@@H]1CNCCN1
CAS DataBase Reference	75336-86-6(CAS DataBase Reference)
FDA UNII	P4XU643R8W
UNSPSC Code	12352005
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS02,GHS07

Signal word

Danger

Hazard statements

H228-H315-H319-H335

Precautionary statements

P210-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Hazard Codes

F,C,Xi

Risk Statements

11-36/37/38-34

Safety Statements

16-26-36/37/39-45-36

RIDADR

UN 1325 4.1/PG 2

WGK Germany

HazardClass

4.1

PackingGroup

III

HS Code

29335990

Storage Class

4.1B - Flammable solid hazardous materials

Hazard Classifications

Eye Irrit. 2
Flam. Sol. 1
Skin Irrit. 2
STOT SE 3

Limited Quantities

1.0 Kg (2.2 lbs)

Excepted Quantities

Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

NFPA 704

	2
3		1

(R)-(-)-2-Methylpiperazine price More Price(41)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	397164	(R)-(?)-2-Methylpiperazine 97%	75336-86-6	1g	$50.2	2026-04-30	Buy
Sigma-Aldrich	SAB1305286	ANTI-RMP (URI)(C-TERMINAL) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution	75336-86-6	400μL	$461	2023-01-07	Buy
TCI Chemical	M2091	(R)-(-)-2-Methylpiperazine >98.0%(GC)(T)	75336-86-6	5g	$119	2026-04-30	Buy
TCI Chemical	M2091	(R)-(-)-2-Methylpiperazine >98.0%(GC)(T)	75336-86-6	25g	$378	2026-04-30	Buy
AstaTech	29365	(R)-2-METHYLPIPERAZINE 98%	75336-86-6	5G	$11	2026-04-30	Buy

Product number	Packaging	Price	Buy
397164	1g	$50.2	Buy
SAB1305286	400μL	$461	Buy
M2091	5g	$119	Buy
M2091	25g	$378	Buy
29365	5G	$11	Buy

(R)-(-)-2-Methylpiperazine Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystalline powder

Uses

Valuable synthon for quinoline antibacterials.

Synthesis

(R)-2-METHYL PIPERAZINE (L)TARTARIC ACID SALT

126458-16-0

75336-86-6

General procedure for the synthesis of (R)-(-)-2-methylpiperazine L-tartrate from (R)-2-methylpiperazine L-tartrate: (R)-2-methylpiperazine L-tartrate (from Example 4) was dissolved in water (182 L) and branched octane (200 L), added to a 4,000 L reactor and stirred until completely dissolved. Subsequently, more branched octane (530 L) was added to the reactor and a 50% sodium hydroxide solution (1120 kg) was slowly added over a temperature range of 35°C to 52°C. The reaction mixture was heated to 80 °C with continuous stirring for 2 h. The lower aqueous phase was then separated and transferred to a 4000 L receiver. The organic phase in the reactor was cooled to 21°C, filtered through a 48-inch Nutsche filter, and the filtrate was transferred to a 1200L reactor. The 4000L reactor and filter were rinsed with branched octane (300L). The solid product was dried over nitrogen at 25 °C to give a final 24.9 kg (67% yield) of (R)-(-)-2-methylpiperazine with an optical purity of not less than 99% ee (as determined by chiral HPLC). The pH of the aqueous phase in the receiver was adjusted to 8.4 with acetic acid (812 kg) prior to treatment.The overall yield of (R)-(-)-2-methylpiperazine was 42% starting from (R)-2-methylpiperazine L-tartrate. The melting point of the product was 91-93 °C.1H NMR (400 MHz, CDCl3) δ: 2.97-2.68 (6H, m), 2.35 (1H, dd, J = 11.7, 10.2 Hz), 1.61 (2H, s), 1.00 (3H, d, J = 6.7 Hz), 0.00 (TMS, ref).13C NMR ( 100MHz, CDCl3) δ: 54.14(t), 51.89(d), 47.43(t), 46.46(t), 20.08(q), 0.00 (TMS, ref.) IR (mineral oil paste) νmax: 3220(s, br), 2819(s), 2748, 2042(w), 1995(w), 1981(w), 1328, 1328(s, d, J = 6.7Hz), 0.00 (TMS, ref.). (w), 1328, 1279, 1137, 1094, 960, 859(s), 845(s), 795(s), 621(s) cm-1. HRMS (FAB) calculated value for C5H12N2 [M+H]+: 101.1079, measured value: 101.1080. [α]25D = -17° (c 0.85, CH2Cl2). Elemental analysis calculated values for C5H12N2: C, 59.96; H, 12.07; N, 27.97. measured values: C, 59.25; H, 11.71; N, 27.64.

References

[1] Patent: WO2004/829, 2003, A1. Location in patent: Page 25-26

(R)-(-)-2-Methylpiperazine synthesis

Synthesis of (R)-(-)-2-Methylpiperazine from 2-Methylpiperazine

(R)-(-)-2-Methylpiperazine Preparation Products And Raw materials

Raw materials

(R)-2-METHYL PIPERAZINE (L)TARTARIC ACID SALT Water Sodium hydroxide (S)-(+)-2-Methylpiperazine 2-Methylpiperazine

Preparation Products

(R)-1-Boc-3-methylpiperazine SINOVA SL-02580 Piperazine, 3-methyl-1-(methylsulfonyl)-, (3R)- (3R)-1-(3-Chloropyridin-2-yl)-3-methylpiperazine 1-(4-Fluoro-2-(trifluoromethyl)phenyl)-3-methylpiperazine

R)-Methyl 4-(3-Methylpiperazin-1-yl)benzoate 1-BENZYL-3(R)-METHYL-PIPERAZINE

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(R)-(-)-2-Methylpiperazine Suppliers

Global( 294)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hebei Ganmiao New material Technology Co., LTD	+86-17332992504	sales8@hbganmiao.com	China	300	58
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21590	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29819	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30227	58

Supplier	Advantage
Hebei Ganmiao New material Technology Co., LTD	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58
Career Henan Chemica Co	58

View Lastest Price from (R)-(-)-2-Methylpiperazine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-03-30	(R)-(-)-2-Methylpiperazine 75336-86-6	US $0.00-0.00 / KG	1KG	99%	2000	Shenzhen Nexcon Pharmatechs Ltd.
2025-11-18	(R)-(-)-2-Methylpiperazine 75336-86-6	US $1.10 / g	1g	99.00%	100 Tons	Dideu Industries Group Limited
2024-08-20	(R)-(-)-2-Methylpiperazine 75336-86-6	US $10.00-7.00 / kg	1kg	98%	20ton	Hebei Ganmiao New material Technology Co., LTD

(R)-(-)-2-Methylpiperazine
75336-86-6
US $0.00-0.00 / KG
99%
Shenzhen Nexcon Pharmatechs Ltd.

(R)-(-)-2-Methylpiperazine
75336-86-6
US $1.10 / g
99.00%
Dideu Industries Group Limited

(R)-(-)-2-Methylpiperazine
75336-86-6
US $10.00-7.00 / kg
98%
Hebei Ganmiao New material Technology Co., LTD

(R)-(-)-2-Methylpiperazine Spectrum

(R)-(-)-2-Methylpiperazine(75336-86-6)¹HNMR (R)-(-)-2-Methylpiperazine(75336-86-6)Raman (R)-(-)-2-Methylpiperazine(75336-86-6)FT-IR (R)-(-)-2-Methylpiperazine(75336-86-6)IR

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R-MP (R)-(-)-2-METHYLPIPERAZINE (R)-2-METHYLPIPERAZINE PIPERAZINE, 2-METHYL-, (2R)- R-(-)-2-Methylpiperazine100.15 (R)-(-)-2-Methylpiperazine,98+% (R)-(-)-2-Methylpiperazine, 99+%, ee 99+% (R)-(-)-2-METHYLPIPERAZINE , EE 99% (R)-(-)-2-METHYL PIPERAZINE HCL (R)-2-methylpiperadine (2R)-2-Methylpiperazine (R)-(-)-2-Methylpiperazine ANTI-RMP (URI)(C-TERMINAL) antibody produced in rabbit C19orf2 NNX3 PPP1R19 URI1 (R)-(-)-2-Methylpiperazine 97% (R)-(-)-2-Methylpiperazine≥ 99% (GC) (R)-(-)-2-Methylpiperazine> (R)-(-)-2-Methylpiperazine ISO 9001：2015 REACH (R)-(-)-2-Methylpiperazine 75336-86-6 Phenylephrine Impurity 84 75336-86-6 Piperazines Heterocyclic Building Blocks Asymmetric Synthesis Chiral Building Blocks Chiral Building Blocks Heterocyclic Building Blocks Piperaizine Piperazines Chiral Compounds