(R)-(-)-2-Methylpiperazine
- CAS No.
- 75336-86-6
- Chemical Name:
- (R)-(-)-2-Methylpiperazine
- Synonyms
- (R)-2-METHYLPIPERAZINE;R-MP;NNX3;URI1;C19orf2;PPP1R19;(R)-2-methylpiperadine;(2R)-2-Methylpiperazine;Phenylephrine Impurity 84;(R)-(-)-2-METHYLPIPERAZINE
- CBNumber:
- CB9445086
- Molecular Formula:
- C5H12N2
- Molecular Weight:
- 100.16
- MDL Number:
- MFCD00192317
- MOL File:
- 75336-86-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 91-93 °C (lit.) |
|---|---|
| Boiling point | 155-156 °C |
| alpha | -18 º (c=1, toluene) |
| Density | 0.9305 (estimate) |
| refractive index | 1.4378 (estimate) |
| Flash point | 149 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| pka | 9.31±0.40(Predicted) |
| form | Crystalline Powder, Crystals and/or Chunks |
| color | White to yellow |
| optical activity | [α]20/D 16.5°, c = 5 in benzene |
| Water Solubility | soluble |
| Sensitive | Air Sensitive & Hygroscopic |
| BRN | 3647994 |
| InChI | 1S/C5H12N2/c1-5-4-6-2-3-7-5/h5-7H,2-4H2,1H3/t5-/m1/s1 |
| InChIKey | JOMNTHCQHJPVAZ-RXMQYKEDSA-N |
| SMILES | C[C@@H]1CNCCN1 |
| CAS DataBase Reference | 75336-86-6(CAS DataBase Reference) |
| FDA UNII | P4XU643R8W |
| UNSPSC Code | 12352005 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H228-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P302+P352-P305+P351+P338 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | Eyeshields, Gloves, type P3 (EN 143) respirator cartridges | |||||||||
| Hazard Codes | F,C,Xi | |||||||||
| Risk Statements | 11-36/37/38-34 | |||||||||
| Safety Statements | 16-26-36/37/39-45-36 | |||||||||
| RIDADR | UN 1325 4.1/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| HazardClass | 4.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29335990 | |||||||||
| Storage Class | 4.1B - Flammable solid hazardous materials | |||||||||
| Hazard Classifications | Eye Irrit. 2 Flam. Sol. 1 Skin Irrit. 2 STOT SE 3 |
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| Limited Quantities | 1.0 Kg (2.2 lbs) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml) | |||||||||
| NFPA 704 |
|
(R)-(-)-2-Methylpiperazine price More Price(77)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 397164 | (R)-(?)-2-Methylpiperazine 97% | 75336-86-6 | 1g | $50.2 | 2026-04-30 | Buy |
| Sigma-Aldrich | SAB1305286 | ANTI-RMP (URI)(C-TERMINAL) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution | 75336-86-6 | 400μL | $461 | 2023-01-07 | Buy |
| TCI Chemical | M2091 | (R)-(-)-2-Methylpiperazine >98.0%(GC)(T) | 75336-86-6 | 5g | $119 | 2026-04-30 | Buy |
| TCI Chemical | M2091 | (R)-(-)-2-Methylpiperazine >98.0%(GC)(T) | 75336-86-6 | 25g | $378 | 2026-04-30 | Buy |
| Usbiological | 580862 | URI1 PurifiedbyProteinGaffinitychromatography. | 50ug | $509 | 2026-06-03 | Buy |
(R)-(-)-2-Methylpiperazine Chemical Properties, Uses, Production
Chemical Properties
white to light yellow crystalline powder
Uses
Valuable synthon for quinoline antibacterials.
Synthesis
126458-16-0
75336-86-6
General procedure for the synthesis of (R)-(-)-2-methylpiperazine L-tartrate from (R)-2-methylpiperazine L-tartrate: (R)-2-methylpiperazine L-tartrate (from Example 4) was dissolved in water (182 L) and branched octane (200 L), added to a 4,000 L reactor and stirred until completely dissolved. Subsequently, more branched octane (530 L) was added to the reactor and a 50% sodium hydroxide solution (1120 kg) was slowly added over a temperature range of 35°C to 52°C. The reaction mixture was heated to 80 °C with continuous stirring for 2 h. The lower aqueous phase was then separated and transferred to a 4000 L receiver. The organic phase in the reactor was cooled to 21°C, filtered through a 48-inch Nutsche filter, and the filtrate was transferred to a 1200L reactor. The 4000L reactor and filter were rinsed with branched octane (300L). The solid product was dried over nitrogen at 25 °C to give a final 24.9 kg (67% yield) of (R)-(-)-2-methylpiperazine with an optical purity of not less than 99% ee (as determined by chiral HPLC). The pH of the aqueous phase in the receiver was adjusted to 8.4 with acetic acid (812 kg) prior to treatment.The overall yield of (R)-(-)-2-methylpiperazine was 42% starting from (R)-2-methylpiperazine L-tartrate. The melting point of the product was 91-93 °C.1H NMR (400 MHz, CDCl3) δ: 2.97-2.68 (6H, m), 2.35 (1H, dd, J = 11.7, 10.2 Hz), 1.61 (2H, s), 1.00 (3H, d, J = 6.7 Hz), 0.00 (TMS, ref).13C NMR ( 100MHz, CDCl3) δ: 54.14(t), 51.89(d), 47.43(t), 46.46(t), 20.08(q), 0.00 (TMS, ref.) IR (mineral oil paste) νmax: 3220(s, br), 2819(s), 2748, 2042(w), 1995(w), 1981(w), 1328, 1328(s, d, J = 6.7Hz), 0.00 (TMS, ref.). (w), 1328, 1279, 1137, 1094, 960, 859(s), 845(s), 795(s), 621(s) cm-1. HRMS (FAB) calculated value for C5H12N2 [M+H]+: 101.1079, measured value: 101.1080. [α]25D = -17° (c 0.85, CH2Cl2). Elemental analysis calculated values for C5H12N2: C, 59.96; H, 12.07; N, 27.97. measured values: C, 59.25; H, 11.71; N, 27.64.
References
[1] Patent: WO2004/829, 2003, A1. Location in patent: Page 25-26
(R)-(-)-2-Methylpiperazine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Sichuan Argalbio Technology Co,.Ltd | 028-028-60651388 13980413900 | slyu@hengkangtech.com | China | 575 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| INTATRADE GmbH | +49 3493/605464 | sales@intatrade.de | Germany | 3563 | 66 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 5996 | 61 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| TCI (Shanghai) Development Co., Ltd. | 021-67121386 | Sales-CN@TCIchemicals.com | China | 24512 | 81 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 |
View Latest Price from (R)-(-)-2-Methylpiperazine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-08-20 | (R)-(-)-2-Methylpiperazine
75336-86-6
|
$1.10 | 1g | 99.00% | 100 Tons | Dideu Industries Group Limited | |
 |
2026-08-13 | (R)-(-)-2-Methylpiperazine
75336-86-6
|
1KG | 99% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2024-08-20 | (R)-(-)-2-Methylpiperazine
75336-86-6
|
$7.00-10.00 | 1kg | 98% | 20ton | Hebei Ganmiao New material Technology Co., LTD |
-
- (R)-(-)-2-Methylpiperazine
75336-86-6
- $1.10
- 99.00%
- Dideu Industries Group Limited
-
- (R)-(-)-2-Methylpiperazine
75336-86-6
- 99%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- (R)-(-)-2-Methylpiperazine
75336-86-6
- $7.00-10.00
- 98%
- Hebei Ganmiao New material Technology Co., LTD
