ChemicalBook >> CAS DataBase List >>ABT-888
ABT-888
- CAS No.
- 912445-05-7
- Chemical Name:
- ABT-888
- Synonyms
- ABT-88;ABT-888;Willipani;ABT888 HCl;Veliparib HCl;1592732-453-0;Veliparib 2HCl;ABT 888;ABT888;ABT888(2HCl salt);ABT-888 USP/EP/BP
- CBNumber:
- CB42473798
- Molecular Formula:
- C13H16N4O
- Molecular Weight:
- 244.296
- MDL Number:
- MFCD12407402
- MOL File:
- 912445-05-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Last updated:2026-04-21 10:31:43
| Product description | Number | Pack Size | Price |
| ABT-888 (hydrochloride) ≥98% | 11505 | 1mg | $44 |
| ABT-888 (hydrochloride) ≥98% | 11505 | 5mg | $109 |
| ABT-888 (hydrochloride) ≥98% | 11505 | 10mg | $142 |
| ABT-888 (hydrochloride) ≥98% | 11505 | 25mg | $267 |
| Veliparibdihydrochloride ≥98%(HPLC) | 7026 | 50 | $125 |
| More product size | |||
| Melting point | >173°C (dec.) |
|---|---|
| storage temp. | Refrigerator |
| solubility | Methanol (Slightly, Heated), THF (Slightly, Heated) |
| form | Colorless to white crystalline solid. |
| color | Off-White to Dark Yellow |
| InChI | InChI=1/C13H16N4O/c1-7-5-6-15-10(7)13-16-9-4-2-3-8(12(14)18)11(9)17-13/h2-4,7,10,15H,5-6H2,1H3,(H2,14,18)(H,16,17)/t7-,10/s3 |
| InChIKey | FXRVOXLVQCUUGN-IEOOLIIMNA-N |
| SMILES | C1=C(C(=O)N)C2=C(NC(C3[C@H](C)CCN3)=N2)C=C1 |&1:10,r| |
| NCI Dictionary of Cancer Terms | ABT-888 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H317 |
| Precautionary statements | P280-P305+P351+P338 |
ABT-888 price More Price(33)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11505 | ABT-888 (hydrochloride) ≥98% | 912445-05-7 | 1mg | $44 | 2024-03-01 | Buy |
| Cayman Chemical | 11505 | ABT-888 (hydrochloride) ≥98% | 912445-05-7 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 11505 | ABT-888 (hydrochloride) ≥98% | 912445-05-7 | 10mg | $142 | 2024-03-01 | Buy |
| Cayman Chemical | 11505 | ABT-888 (hydrochloride) ≥98% | 912445-05-7 | 25mg | $267 | 2024-03-01 | Buy |
| Tocris | 7026 | Veliparibdihydrochloride ≥98%(HPLC) | 912445-05-7 | 50 | $125 | 2021-12-16 | Buy |
ABT-888 Chemical Properties,Uses,Production
Uses
ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo. Potent PARP inhibitor.
in vivo
The oral bioavailability of Veliparib is 56%-92% in mice, SD rats, beagle dogs, and cynomolgus monkeys after oral administration[1]. Veliparib (25 mg/kg, i.p.) can improve tumor growth delay in a NCI-H460 xenograft model. Combination with radiation, veliparib decreases the tumor vessel formation[3]. Veliparib reduces intratumor PAR levels by more than 95% at a dose of 3 and 12.5 mg/kg in A375 and Colo829 xenograft models and the suppression can be maintained over time[4].
IC 50
PARP-2: 2.9 nM (Ki); PARP-1: 5.2 nM (Ki)
storage
Store at -20°C
ABT-888 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 192)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15079 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29821 | 58 |
| Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shenzhen Excellent Biotech Co., Ltd. | 13480692018 | ramyan@ex-biotech.com | CHINA | 954 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49977 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | sales@win-winchemical.com | China | 14304 | 58 |
Related articles
- ABT-888: pharmacokinetic, mechanism of action and safety
- ABT-888, a potent PARP inhibitor with favorable pharmacokinetics, shows promise in cancer therapy.
- Dec 1，2023
- Biological activity ABT-888
- Veliparib (ABT-888) is a potent inhibitor of PARP1 and PARP2 with Ki of 5.2 nM and 2.9 nM in cell-free assays.
- Oct 11，2019
View Lastest Price from ABT-888 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-20 | Veliparib dihydrochloride
912445-05-7
|
US $30.00-71.00 / mg | 98.00% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-11-26 | Veliparib dihydrochloride
912445-05-7
|
US $0.00-0.00 / kg | 1kg | 99%, Single impurity＜0.1 | 1 ton | Nanjing Fred Technology Co., Ltd | |
 |
2022-12-29 | ABT-888
912445-05-7
|
US $1.00 / g | 10g | 99.5% | 1000kg | Guangzhou Biocar Biotechnology Co.,Ltd. |
-
- Veliparib dihydrochloride
912445-05-7
- US $30.00-71.00 / mg
- 98.00%
- TargetMol Chemicals Inc.
-
- Veliparib dihydrochloride
912445-05-7
- US $0.00-0.00 / kg
- 99%, Single impurity＜0.1
- Nanjing Fred Technology Co., Ltd
-
- ABT-888
912445-05-7
- US $1.00 / g
- 99.5%
- Guangzhou Biocar Biotechnology Co.,Ltd.
912445-05-7(ABT-888)Related Search:
ABT-888
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benimidazole-4-
carboxamide,dihydrochloridesalt
2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride
Veliparib dihydrochloride
ABT-888(Veliparib dihydrochloride)
ABT-888 dihydrochloride
ABT888 HCl
Veliparib hydrochloride
2-[(2S)-2-Methyl-2-pyrrolidinyl]-1H-benziMidazole-4-carboxaMide
(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benimidazole-4-carboxamide dihydrochloride (VELIPARIB)
1H-Benzimidazole-7-carboxamide, 2-[(2R)-2-methyl-2-pyrrolidinyl]-, hydrochloride (1:2)
Veliparib (ABT-888) dihydrochloride
2-[(2R)-2-Methylpyrrolidin-2-yl]-1H-benzimidazole-7-carboxamide dihydrochloride
Veliparib 2HCl
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-benzimidazole-4-carboxamide,dihydrochloride
(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-4-carboxamide dihydrochloride
Veliparib dihydrochloride, >=98%
ABT-88
ABT888(Veliparib HCL)
ABT 888;ABT888
ABT888(2HCl salt)
Veliparib (ABT-888 hydrochloride)
Willipani
ABT 888 dihydrochloride - Veliparib dihydrochloride | A 861695 dihydrochloride
Veliparib HCl
ABT-888 USP/EP/BP
Veliparib dihydrochloride salt
Veliparibdihydrochloride/ABT-888
(R)-2-(2-Methylpyrrolidin-2-yl)-1H-benzo[d]imidazole-7-carboxamide dihydrochloride
Veliparib dihydrochloride, 10 mM in DMSO
1592732-453-0
912445-05-7
Inhibitors
Inhibitor
API
