NU1025
- CAS No.
- 90417-38-2
- Chemical Name:
- NU1025
- Synonyms
- NU1025;NSC 696807;NU1025 ，S7730;NU 1025;NU 1025;NU1025 USP/EP/BP;NU1025 (NSC 696807);NU1025, 10 mM in DMSO;PARP Inhibitor VI, NU1025;8-Hydroxy-2-methylquinazolin-4(3H);8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE
- CBNumber:
- CB0214872
- Molecular Formula:
- C9H8N2O2
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD00942555
- MOL File:
- 90417-38-2.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 253-258°C |
|---|---|
| Boiling point | 345.4±44.0 °C(Predicted) |
| Density | 1.42 |
| storage temp. | −20°C |
| solubility | DMSO: 35 mg/mL, soluble |
| form | solid |
| pka | 8.68±0.20(Predicted) |
| color | off-white |
| InChI | 1S/C9H8N2O2/c1-5-10-8-6(9(13)11-5)3-2-4-7(8)12/h2-4,12H,1H3,(H,10,11,13) |
| InChIKey | YJDAOHJWLUNFLX-UHFFFAOYSA-N |
| SMILES | CC1=Nc2c(O)cccc2C(=O)N1 |
| CAS DataBase Reference | 90417-38-2 |
| FDA UNII | X5ZL2C7V9B |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
NU1025 price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N7287 | NU-1025 ≥97% (HPLC), solid | 90417-38-2 | 5mg | $177 | 2026-04-30 | Buy |
| Sigma-Aldrich | 493800 | PARP Inhibitor VI, NU1025 | 90417-38-2 | 5mg | $253 | 2026-04-30 | Buy |
| Cayman Chemical | 14534 | NU 1025 ≥98% | 90417-38-2 | 1mg | $35 | 2026-04-30 | Buy |
| Cayman Chemical | 14534 | NU 1025 ≥98% | 90417-38-2 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 14534 | NU 1025 ≥98% | 90417-38-2 | 25mg | $376 | 2026-04-30 | Buy |
NU1025 Chemical Properties,Uses,Production
Description
NU 1025 is an inhibitor of poly(ADP-
Chemical Properties
Off-White to Pale Yellow Solid
Uses
NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical]
Uses
A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.
Definition
ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.
Biological Activity
Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively.
References
[1] ROGER J. GRIFFIN. Resistance-Modifying Agents. 5. 1 Synthesis and Biological Properties of Quinazolinone Inhibitors of the DNA Repair Enzyme Poly(ADP-ribose) Polymerase (PARP)[J]. Journal of Medicinal Chemistry, 1998, 41 26: 5247-5256. DOI: 10.1021/jm980273t
[2] KJ BOWMAN. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064[J]. British Journal of Cancer, 1998, 78 10: 1269-1277. DOI: 10.1038/bjc.1998.670
[3] C A DELANEY. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines.[J]. Clinical Cancer Research, 2000, 6 7: 2860-2867.
[4] SLAWOMIR KUMALA. Repair of DNA strand breaks in a minichromosome in vivo: kinetics, modeling, and effects of inhibitors.[J]. PLoS ONE, 2013: e52966. DOI: 10.1371/journal.pone.0052966
NU1025 Preparation Products And Raw materials
Raw materials
1of4
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32273 | 50 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4861 | 55 | |
| YouCoChem (Beijing) Chemical Technology Co., Ltd. | 18800159827 | youcochem@163.com | China | 163 | 50 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8435 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
